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- W2107120977 endingPage "291" @default.
- W2107120977 startingPage "273" @default.
- W2107120977 abstract "SLE T cells may play a key role in autoantibody production in SLE B cells. In addition, accumulating evidence has shown that SLE T cells participate in the attack on target cells or tissues through the overproduction of pro-inflammatory cytokines or an increase in cell-to-cell adhesion. Thus, the functional abnormality of SLE T cells appears to be pivotal to an understanding of SLE pathogenesis. Accumulating evidence suggests that potential defects may reside in the proximal signal transduction around the TCR-CD3 complex. We have demonstrated that the expression of TCR zeta chain is significantly decreased in peripheral blood T cells from SLE patients. To explore the mechanism of defective expression of TCR zeta chain, we examined mRNA of TCR zeta, and found that two alternatively spliced variants such as exon 7 (-) and short 3'-UTR are detected in SLE. We review the possible role of the TCR zeta defects in autoimmunity and discuss how the splicing variants lead to downregulated protein expression of TCR zeta chain." @default.
- W2107120977 created "2016-06-24" @default.
- W2107120977 creator A5057335320 @default.
- W2107120977 creator A5071576444 @default.
- W2107120977 creator A5083314956 @default.
- W2107120977 date "2004-01-01" @default.
- W2107120977 modified "2023-09-23" @default.
- W2107120977 title "ALTERED EXPRESSION OF THE T CELL RECEPTOR-CD3 COMPLEX IN SYSTEMIC LUPUS ERYTHEMATOSUS" @default.
- W2107120977 cites W10986776 @default.
- W2107120977 cites W1499192320 @default.
- W2107120977 cites W1504079946 @default.
- W2107120977 cites W1515780008 @default.
- W2107120977 cites W1542264887 @default.
- W2107120977 cites W1544832651 @default.
- W2107120977 cites W1556068330 @default.
- W2107120977 cites W1559177739 @default.
- W2107120977 cites W1590085139 @default.
- W2107120977 cites W1688883032 @default.
- W2107120977 cites W1860163656 @default.
- W2107120977 cites W1965830188 @default.
- W2107120977 cites W1966650497 @default.
- W2107120977 cites W1966930760 @default.
- W2107120977 cites W1967555573 @default.
- W2107120977 cites W1978903916 @default.
- W2107120977 cites W1983265475 @default.
- W2107120977 cites W1987273695 @default.
- W2107120977 cites W1990961599 @default.
- W2107120977 cites W1993968805 @default.
- W2107120977 cites W1996025404 @default.
- W2107120977 cites W1997599011 @default.
- W2107120977 cites W1999298531 @default.
- W2107120977 cites W1999457671 @default.
- W2107120977 cites W1999845189 @default.
- W2107120977 cites W2001292797 @default.
- W2107120977 cites W2008773262 @default.
- W2107120977 cites W2008906131 @default.
- W2107120977 cites W2012972418 @default.
- W2107120977 cites W2013136814 @default.
- W2107120977 cites W2013281032 @default.
- W2107120977 cites W2015662929 @default.
- W2107120977 cites W2016127179 @default.
- W2107120977 cites W2018080046 @default.
- W2107120977 cites W2021973588 @default.
- W2107120977 cites W2022099420 @default.
- W2107120977 cites W2025926486 @default.
- W2107120977 cites W2025992578 @default.
- W2107120977 cites W2029328427 @default.
- W2107120977 cites W2029599607 @default.
- W2107120977 cites W2029643208 @default.
- W2107120977 cites W2034699474 @default.
- W2107120977 cites W2036855155 @default.
- W2107120977 cites W2039499980 @default.
- W2107120977 cites W2043912021 @default.
- W2107120977 cites W2044567576 @default.
- W2107120977 cites W2046281946 @default.
- W2107120977 cites W2046823410 @default.
- W2107120977 cites W2046957298 @default.
- W2107120977 cites W2047132622 @default.
- W2107120977 cites W2048148775 @default.
- W2107120977 cites W2048642539 @default.
- W2107120977 cites W2054080837 @default.
- W2107120977 cites W2055981013 @default.
- W2107120977 cites W2058885870 @default.
- W2107120977 cites W2059257370 @default.
- W2107120977 cites W2062450118 @default.
- W2107120977 cites W2063097250 @default.
- W2107120977 cites W2063454166 @default.
- W2107120977 cites W2064496848 @default.
- W2107120977 cites W2068898339 @default.
- W2107120977 cites W2074059194 @default.
- W2107120977 cites W2076762468 @default.
- W2107120977 cites W2087594396 @default.
- W2107120977 cites W2092718033 @default.
- W2107120977 cites W2094186948 @default.
- W2107120977 cites W2094222038 @default.
- W2107120977 cites W2095433140 @default.
- W2107120977 cites W2096179701 @default.
- W2107120977 cites W2112073156 @default.
- W2107120977 cites W2121870374 @default.
- W2107120977 cites W2122360155 @default.
- W2107120977 cites W2126629186 @default.
- W2107120977 cites W2127697725 @default.
- W2107120977 cites W2131323079 @default.
- W2107120977 cites W213700823 @default.
- W2107120977 cites W2144935474 @default.
- W2107120977 cites W2147055245 @default.
- W2107120977 cites W2155308169 @default.
- W2107120977 cites W2158219033 @default.
- W2107120977 cites W2160286042 @default.
- W2107120977 cites W2161816553 @default.
- W2107120977 cites W2167980515 @default.
- W2107120977 cites W2170220756 @default.
- W2107120977 cites W2172523660 @default.
- W2107120977 cites W2340157552 @default.
- W2107120977 cites W2564152524 @default.
- W2107120977 cites W3153504824 @default.
- W2107120977 cites W4243772775 @default.
- W2107120977 cites W4313333676 @default.