FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107149034> ?p ?o ?g. }

• W2107149034 endingPage "1470" @default.
• W2107149034 startingPage "1463" @default.
• W2107149034 abstract "Quantitative structure–activity relationship (QSAR) approach was carried out for the prediction of inhibitory activity of some novel quinazolinone derivatives on serotonin (5-HT7) using modified ant colony (ACO) method and adaptive neuro-fuzzy interference system (ANFIS) combined with shuffling cross-validation technique. A modified ACO algorithm is utilized to select the most important variables in QSAR modeling and then these variables were used as inputs of ANFIS to predict 5-HT7 receptor binding activities of quinazolinone derivatives. The best descriptors describing the inhibition mechanism are Qmax, Se, Hy, PJI3 and DELS which are among electronic, constitutional, geometric and empirical descriptors. The statistical parameters of R2 and root mean square error are 0.775 and 0.360, respectively. The ability and robustness of modified ACO-ANFIS model in predicting inhibition behavior of quinazolinone derivatives (pIC50) are illustrated by validation techniques of leave-one-out and leave-multiple-out cross-validations and also by Y-randomization technique. Comparison of the modified ACO-ANFIS method with two other methods, that is, stepwise MLR-ANFIS and GA-PLS-ANFIS were also studied and the results indicated that the proposed model in this work is superior over the others." @default.
• W2107149034 created "2016-06-24" @default.
• W2107149034 creator A5035187631 @default.
• W2107149034 creator A5048205204 @default.
• W2107149034 date "2009-04-01" @default.
• W2107149034 modified "2023-09-25" @default.
• W2107149034 title "Quantitative structure–activity relationship study of serotonin (5-HT7) receptor inhibitors using modified ant colony algorithm and adaptive neuro-fuzzy interference system (ANFIS)" @default.
• W2107149034 cites W1545231783 @default.
• W2107149034 cites W1648525405 @default.
• W2107149034 cites W1973475326 @default.
• W2107149034 cites W1976397137 @default.
• W2107149034 cites W1985254321 @default.
• W2107149034 cites W1994806208 @default.
• W2107149034 cites W1999985301 @default.
• W2107149034 cites W2008711606 @default.
• W2107149034 cites W2035250366 @default.
• W2107149034 cites W2046738003 @default.
• W2107149034 cites W2058206814 @default.
• W2107149034 cites W2067146173 @default.
• W2107149034 cites W2070290419 @default.
• W2107149034 cites W2080808615 @default.
• W2107149034 cites W2084417734 @default.
• W2107149034 cites W2087661061 @default.
• W2107149034 cites W2090681269 @default.
• W2107149034 cites W2115637931 @default.
• W2107149034 cites W2138525748 @default.
• W2107149034 cites W2142053997 @default.
• W2107149034 cites W2166596942 @default.
• W2107149034 cites W2167920923 @default.
• W2107149034 cites W2197112043 @default.
• W2107149034 cites W2414538829 @default.
• W2107149034 cites W2912565176 @default.
• W2107149034 doi "https://doi.org/10.1016/j.ejmech.2008.09.050" @default.
• W2107149034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19013691" @default.
• W2107149034 hasPublicationYear "2009" @default.
• W2107149034 type Work @default.
• W2107149034 sameAs 2107149034 @default.
• W2107149034 citedByCount "26" @default.
• W2107149034 countsByYear W21071490342012 @default.
• W2107149034 countsByYear W21071490342013 @default.
• W2107149034 countsByYear W21071490342015 @default.
• W2107149034 countsByYear W21071490342016 @default.
• W2107149034 countsByYear W21071490342017 @default.
• W2107149034 countsByYear W21071490342018 @default.
• W2107149034 countsByYear W21071490342020 @default.
• W2107149034 countsByYear W21071490342022 @default.
• W2107149034 countsByYear W21071490342023 @default.
• W2107149034 crossrefType "journal-article" @default.
• W2107149034 hasAuthorship W2107149034A5035187631 @default.
• W2107149034 hasAuthorship W2107149034A5048205204 @default.
• W2107149034 hasConcept C104317684 @default.
• W2107149034 hasConcept C11413529 @default.
• W2107149034 hasConcept C119857082 @default.
• W2107149034 hasConcept C154945302 @default.
• W2107149034 hasConcept C164126121 @default.
• W2107149034 hasConcept C164923092 @default.
• W2107149034 hasConcept C185592680 @default.
• W2107149034 hasConcept C186060115 @default.
• W2107149034 hasConcept C186108316 @default.
• W2107149034 hasConcept C195975749 @default.
• W2107149034 hasConcept C2777162773 @default.
• W2107149034 hasConcept C33923547 @default.
• W2107149034 hasConcept C40128228 @default.
• W2107149034 hasConcept C41008148 @default.
• W2107149034 hasConcept C55493867 @default.
• W2107149034 hasConcept C58166 @default.
• W2107149034 hasConcept C63479239 @default.
• W2107149034 hasConcept C71240020 @default.
• W2107149034 hasConcept C86803240 @default.
• W2107149034 hasConceptScore W2107149034C104317684 @default.
• W2107149034 hasConceptScore W2107149034C11413529 @default.
• W2107149034 hasConceptScore W2107149034C119857082 @default.
• W2107149034 hasConceptScore W2107149034C154945302 @default.
• W2107149034 hasConceptScore W2107149034C164126121 @default.
• W2107149034 hasConceptScore W2107149034C164923092 @default.
• W2107149034 hasConceptScore W2107149034C185592680 @default.
• W2107149034 hasConceptScore W2107149034C186060115 @default.
• W2107149034 hasConceptScore W2107149034C186108316 @default.
• W2107149034 hasConceptScore W2107149034C195975749 @default.
• W2107149034 hasConceptScore W2107149034C2777162773 @default.
• W2107149034 hasConceptScore W2107149034C33923547 @default.
• W2107149034 hasConceptScore W2107149034C40128228 @default.
• W2107149034 hasConceptScore W2107149034C41008148 @default.
• W2107149034 hasConceptScore W2107149034C55493867 @default.
• W2107149034 hasConceptScore W2107149034C58166 @default.
• W2107149034 hasConceptScore W2107149034C63479239 @default.
• W2107149034 hasConceptScore W2107149034C71240020 @default.
• W2107149034 hasConceptScore W2107149034C86803240 @default.
• W2107149034 hasIssue "4" @default.
• W2107149034 hasLocation W21071490341 @default.
• W2107149034 hasLocation W21071490342 @default.
• W2107149034 hasOpenAccess W2107149034 @default.
• W2107149034 hasPrimaryLocation W21071490341 @default.
• W2107149034 hasRelatedWork W1984052474 @default.
• W2107149034 hasRelatedWork W2005875374 @default.
• W2107149034 hasRelatedWork W2016443201 @default.
• W2107149034 hasRelatedWork W2034691125 @default.
• W2107149034 hasRelatedWork W2034777576 @default.

• next