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• W2107164056 abstract "ABSTRACT Vesicular stomatitis virus (VSV) matrix (M) protein blocks host mRNA export from the nucleus and thereby inhibits interferon induction in infected cells. M mutants with mutations of methionine 51 (M51) lack this shutoff function. We examined pathogenesis of a VSV M mutant with a deletion of M51 (VSVΔM51) after intranasal infection of BALB/c mice and found an unexpected phenotype. Mice that received VSVΔM51 experienced a more rapid but overall less severe weight loss than mice that received the recombinant wild-type VSV (rwtVSV). Rapid weight loss was not explained by faster initial replication because VSVΔM51 replication was controlled faster than rwtVSV replication in the lungs and did not spread systemically like rwtVSV. This faster control of VSVΔM51 correlated with a more rapid induction of interferon in the lung. Because tumor necrosis factor alpha (TNF-α) is associated with weight loss, we examined TNF-α induction in mice infected with rwtVSV or VSVΔM51. We found more-rapid induction of TNF-α by the mutant at early times after infection, while rwtVSV induced more TNF-α later in infection. This result suggested that TNF-α induction might explain both the rapid weight loss caused by the mutant and the overall greater weight loss caused by the rwtVSV. Using TNF-α knockout mice (C57BL/6 background), we showed that weight loss following rwtVSV infection was greatly reduced in the absence of TNF-α. Although the rapid weight loss caused by VSVΔM51 was less pronounced in C57BL/6 mice, it was eliminated in the absence of TNF-α. These results indicate a role for TNF-α in the pathogenesis of VSV." @default.
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• W2107164056 date "2006-07-15" @default.
• W2107164056 modified "2023-10-16" @default.
• W2107164056 title "Rapid Pathogenesis Induced by a Vesicular Stomatitis Virus Matrix Protein Mutant: Viral Pathogenesis Is Linked to Induction of Tumor Necrosis Factor Alpha" @default.
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• W2107164056 doi "https://doi.org/10.1128/jvi.00478-06" @default.
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