Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107181486> ?p ?o ?g. }
- W2107181486 endingPage "1018" @default.
- W2107181486 startingPage "1012" @default.
- W2107181486 abstract "N-nitroso compounds represent a common type of environmental and endogenous DNA-damaging agents. After metabolic activation, many N-nitroso compounds are converted into a diazoacetate intermediate that can react with nucleobases to give carboxymethylated DNA adducts such as N3-carboxymethylthymidine (N3-CMdT) and O4-carboxymethylthymidine (O4-CMdT). In this study, we constructed non-replicative plasmids carrying a single N3-CMdT or O4-CMdT, site-specifically positioned in the transcribed strand, to investigate how these lesions compromise the flow of genetic information during transcription. Our results revealed that both N3-CMdT and O4-CMdT substantially inhibited DNA transcription mediated by T7 RNA polymerase or human RNA polymerase II in vitro and in human cells. In addition, we found that N3-CMdT and O4-CMdT were miscoding lesions and predominantly directed the misinsertion of uridine and guanosine, respectively. Our results also suggested that these carboxymethylated thymidine lesions may constitute efficient substrates for transcription-coupled nucleotide excision repair in human cells. These findings provided important new insights into the biological consequences of the carboxymethylated DNA lesions in living cells." @default.
- W2107181486 created "2016-06-24" @default.
- W2107181486 creator A5005108610 @default.
- W2107181486 creator A5020545623 @default.
- W2107181486 creator A5025279909 @default.
- W2107181486 creator A5037741645 @default.
- W2107181486 date "2015-01-08" @default.
- W2107181486 modified "2023-09-27" @default.
- W2107181486 title "Transcriptional inhibition and mutagenesis induced by N-nitroso compound-derived carboxymethylated thymidine adducts in DNA" @default.
- W2107181486 cites W1544844984 @default.
- W2107181486 cites W1574673445 @default.
- W2107181486 cites W1603777453 @default.
- W2107181486 cites W1628388640 @default.
- W2107181486 cites W1932006408 @default.
- W2107181486 cites W1967778405 @default.
- W2107181486 cites W1980745500 @default.
- W2107181486 cites W1984650264 @default.
- W2107181486 cites W1988758329 @default.
- W2107181486 cites W1991113904 @default.
- W2107181486 cites W2000989085 @default.
- W2107181486 cites W2007505360 @default.
- W2107181486 cites W2012747915 @default.
- W2107181486 cites W2017835062 @default.
- W2107181486 cites W2018468353 @default.
- W2107181486 cites W2022642195 @default.
- W2107181486 cites W2026968619 @default.
- W2107181486 cites W2032864127 @default.
- W2107181486 cites W2036216041 @default.
- W2107181486 cites W2044896484 @default.
- W2107181486 cites W2046082575 @default.
- W2107181486 cites W2046219406 @default.
- W2107181486 cites W2046360867 @default.
- W2107181486 cites W2060806850 @default.
- W2107181486 cites W2062564859 @default.
- W2107181486 cites W2068043262 @default.
- W2107181486 cites W2070739500 @default.
- W2107181486 cites W2071444261 @default.
- W2107181486 cites W2073266209 @default.
- W2107181486 cites W2078485114 @default.
- W2107181486 cites W2078770291 @default.
- W2107181486 cites W2084369408 @default.
- W2107181486 cites W2090181074 @default.
- W2107181486 cites W2119694706 @default.
- W2107181486 cites W2122436900 @default.
- W2107181486 cites W2128416634 @default.
- W2107181486 cites W2138907118 @default.
- W2107181486 cites W2151552495 @default.
- W2107181486 cites W2155314424 @default.
- W2107181486 cites W2157548007 @default.
- W2107181486 cites W2161391659 @default.
- W2107181486 cites W2161822945 @default.
- W2107181486 cites W2164390042 @default.
- W2107181486 doi "https://doi.org/10.1093/nar/gku1391" @default.
- W2107181486 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4333421" @default.
- W2107181486 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25572317" @default.
- W2107181486 hasPublicationYear "2015" @default.
- W2107181486 type Work @default.
- W2107181486 sameAs 2107181486 @default.
- W2107181486 citedByCount "18" @default.
- W2107181486 countsByYear W21071814862015 @default.
- W2107181486 countsByYear W21071814862016 @default.
- W2107181486 countsByYear W21071814862017 @default.
- W2107181486 countsByYear W21071814862018 @default.
- W2107181486 countsByYear W21071814862019 @default.
- W2107181486 countsByYear W21071814862022 @default.
- W2107181486 countsByYear W21071814862023 @default.
- W2107181486 crossrefType "journal-article" @default.
- W2107181486 hasAuthorship W2107181486A5005108610 @default.
- W2107181486 hasAuthorship W2107181486A5020545623 @default.
- W2107181486 hasAuthorship W2107181486A5025279909 @default.
- W2107181486 hasAuthorship W2107181486A5037741645 @default.
- W2107181486 hasBestOaLocation W21071814861 @default.
- W2107181486 hasConcept C104317684 @default.
- W2107181486 hasConcept C138885662 @default.
- W2107181486 hasConcept C153911025 @default.
- W2107181486 hasConcept C16318435 @default.
- W2107181486 hasConcept C179926584 @default.
- W2107181486 hasConcept C2777108182 @default.
- W2107181486 hasConcept C2777995097 @default.
- W2107181486 hasConcept C2781259782 @default.
- W2107181486 hasConcept C41895202 @default.
- W2107181486 hasConcept C501734568 @default.
- W2107181486 hasConcept C552990157 @default.
- W2107181486 hasConcept C55493867 @default.
- W2107181486 hasConcept C67705224 @default.
- W2107181486 hasConcept C82381507 @default.
- W2107181486 hasConcept C86803240 @default.
- W2107181486 hasConceptScore W2107181486C104317684 @default.
- W2107181486 hasConceptScore W2107181486C138885662 @default.
- W2107181486 hasConceptScore W2107181486C153911025 @default.
- W2107181486 hasConceptScore W2107181486C16318435 @default.
- W2107181486 hasConceptScore W2107181486C179926584 @default.
- W2107181486 hasConceptScore W2107181486C2777108182 @default.
- W2107181486 hasConceptScore W2107181486C2777995097 @default.
- W2107181486 hasConceptScore W2107181486C2781259782 @default.
- W2107181486 hasConceptScore W2107181486C41895202 @default.
- W2107181486 hasConceptScore W2107181486C501734568 @default.
- W2107181486 hasConceptScore W2107181486C552990157 @default.