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- W2107186420 abstract "Recent studies have shown an overexpression of γ-tubulin in human glioblastomas and glioblastoma cell lines. As the 2-year survival rate for glioblastoma is very poor, potential benefit exists for discovering novel chemotherapeutic agents that can inhibit γ-tubulin, which is known to form a ring complex that acts as a microtubule nucleation center. We present experimental evidence that colchicine and combretastatin A-4 bind to γ-tubulin, which are to our knowledge the first drug-like compounds known to interact with γ-tubulin. Molecular dynamics simulations and docking studies were used to analyze the hypothesized γ-tubulin binding domain of these compounds. The suitability of the potential binding modes was evaluated and suggests the subsequent rational design of novel targeted inhibitors of γ-tubulin." @default.
- W2107186420 created "2016-06-24" @default.
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- W2107186420 date "2012-02-15" @default.
- W2107186420 modified "2023-09-23" @default.
- W2107186420 title "Discovery of Small Molecule Inhibitors that Interact with γ-Tubulin" @default.
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- W2107186420 doi "https://doi.org/10.1111/j.1747-0285.2012.01340.x" @default.
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