FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107200112> ?p ?o ?g. }

• W2107200112 endingPage "101" @default.
• W2107200112 startingPage "91" @default.
• W2107200112 abstract "Although silica has been documented to cause apoptotic cell death, the cellular pathways leading to caspase activation have not been extensively investigated. Here we demonstrate in a mouse macrophage cell line (MH-S cells) that alpha-quartz silica exposure (12.5 mug/cm2 to 50 mug/cm2) elicited activation of both caspase 3 and caspase 9, whereas anatase titanium dioxide (TiO2), a non-fibrogenic particle, did not. Silica exposure in vitro also induced apoptosis after 6 h, as measured by the appearance of subdiploid cell fragments in a flow cytometric analysis. Exposure to TiO 2 did not elicit significant apoptosis. Silica-induced apoptosis and caspase 3 activation were, in part, caspase 9 dependent, as determined by their sensitivity to either a general caspase inhibitor (Z-VAD-FMK) or a specific caspase 9 inhibitor (Z-LEHD-FMK). Silica exposure in vitro also elicited significant mitochondrial depolarization after 2 and 6 h of exposure. Cyclosporin A, an inhibitor of the mitochondrial permeability pore, partially decreased mitochondrial depolarization, caspase 3 activation, and caspase 9 activation, suggesting a role for mitochondrial dysfunction in these events. Pepstatin A, an inhibitor of cathepsin D, also decreased mitochondrial depolarization, caspase 3 activation, and caspase 9 activation, whereas leupeptin, an inhibitor of cathepsin B, had no effect. These data suggest that short-term silica exposure in vitro induces both caspase 3 and caspase 9 activity, which appears to participate in apoptosis. Activation of these caspases seems to be dependent, in part, on aspartic proteolysis and loss of mitochondrial integrity." @default.
• W2107200112 created "2016-06-24" @default.
• W2107200112 creator A5029257492 @default.
• W2107200112 creator A5042547189 @default.
• W2107200112 creator A5046768041 @default.
• W2107200112 date "2003-08-12" @default.
• W2107200112 modified "2023-10-01" @default.
• W2107200112 title "Silica-Induced Caspase Activation in Mouse Alveolar Macrophages Is Dependent upon Mitochondrial Integrity and Aspartic Proteolysis" @default.
• W2107200112 cites W121781868 @default.
• W2107200112 cites W1506642042 @default.
• W2107200112 cites W1522763255 @default.
• W2107200112 cites W1582582065 @default.
• W2107200112 cites W1667997885 @default.
• W2107200112 cites W1920479129 @default.
• W2107200112 cites W1942441654 @default.
• W2107200112 cites W1964511841 @default.
• W2107200112 cites W1986916123 @default.
• W2107200112 cites W1998593025 @default.
• W2107200112 cites W2005161116 @default.
• W2107200112 cites W2005571058 @default.
• W2107200112 cites W2006556473 @default.
• W2107200112 cites W2013685285 @default.
• W2107200112 cites W2022569128 @default.
• W2107200112 cites W2023750468 @default.
• W2107200112 cites W2024656201 @default.
• W2107200112 cites W2036803537 @default.
• W2107200112 cites W2039983193 @default.
• W2107200112 cites W2047599398 @default.
• W2107200112 cites W2078215254 @default.
• W2107200112 cites W2087450028 @default.
• W2107200112 cites W2109486481 @default.
• W2107200112 cites W2114962798 @default.
• W2107200112 cites W2119683782 @default.
• W2107200112 cites W2134388096 @default.
• W2107200112 cites W2140955159 @default.
• W2107200112 cites W2142120946 @default.
• W2107200112 cites W2157099277 @default.
• W2107200112 cites W2157531458 @default.
• W2107200112 cites W2161195533 @default.
• W2107200112 cites W2183837523 @default.
• W2107200112 cites W2187241866 @default.
• W2107200112 cites W2325862576 @default.
• W2107200112 cites W3202765395 @default.
• W2107200112 cites W2043411769 @default.
• W2107200112 doi "https://doi.org/10.1093/toxsci/kfg178" @default.
• W2107200112 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12857937" @default.
• W2107200112 hasPublicationYear "2003" @default.
• W2107200112 type Work @default.
• W2107200112 sameAs 2107200112 @default.
• W2107200112 citedByCount "81" @default.
• W2107200112 countsByYear W21072001122013 @default.
• W2107200112 countsByYear W21072001122014 @default.
• W2107200112 countsByYear W21072001122015 @default.
• W2107200112 countsByYear W21072001122016 @default.
• W2107200112 countsByYear W21072001122017 @default.
• W2107200112 countsByYear W21072001122018 @default.
• W2107200112 countsByYear W21072001122020 @default.
• W2107200112 countsByYear W21072001122021 @default.
• W2107200112 countsByYear W21072001122022 @default.
• W2107200112 countsByYear W21072001122023 @default.
• W2107200112 crossrefType "journal-article" @default.
• W2107200112 hasAuthorship W2107200112A5029257492 @default.
• W2107200112 hasAuthorship W2107200112A5042547189 @default.
• W2107200112 hasAuthorship W2107200112A5046768041 @default.
• W2107200112 hasBestOaLocation W21072001122 @default.
• W2107200112 hasConcept C12519072 @default.
• W2107200112 hasConcept C12554922 @default.
• W2107200112 hasConcept C13591479 @default.
• W2107200112 hasConcept C139964883 @default.
• W2107200112 hasConcept C153911025 @default.
• W2107200112 hasConcept C181199279 @default.
• W2107200112 hasConcept C185592680 @default.
• W2107200112 hasConcept C190283241 @default.
• W2107200112 hasConcept C2775883766 @default.
• W2107200112 hasConcept C2775998712 @default.
• W2107200112 hasConcept C2776350231 @default.
• W2107200112 hasConcept C2776714187 @default.
• W2107200112 hasConcept C31573885 @default.
• W2107200112 hasConcept C4141045 @default.
• W2107200112 hasConcept C48297814 @default.
• W2107200112 hasConcept C55493867 @default.
• W2107200112 hasConcept C86803240 @default.
• W2107200112 hasConcept C95444343 @default.
• W2107200112 hasConcept C98424977 @default.
• W2107200112 hasConceptScore W2107200112C12519072 @default.
• W2107200112 hasConceptScore W2107200112C12554922 @default.
• W2107200112 hasConceptScore W2107200112C13591479 @default.
• W2107200112 hasConceptScore W2107200112C139964883 @default.
• W2107200112 hasConceptScore W2107200112C153911025 @default.
• W2107200112 hasConceptScore W2107200112C181199279 @default.
• W2107200112 hasConceptScore W2107200112C185592680 @default.
• W2107200112 hasConceptScore W2107200112C190283241 @default.
• W2107200112 hasConceptScore W2107200112C2775883766 @default.
• W2107200112 hasConceptScore W2107200112C2775998712 @default.
• W2107200112 hasConceptScore W2107200112C2776350231 @default.
• W2107200112 hasConceptScore W2107200112C2776714187 @default.
• W2107200112 hasConceptScore W2107200112C31573885 @default.
• W2107200112 hasConceptScore W2107200112C4141045 @default.

• next