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• W2107201375 abstract "Purpose of review This review discusses the mechanisms involved in the generation of thorny red blood cells (RBCs), known as acanthocytes, in patients with neuroacanthocytosis, a heterogenous group of neurodegenerative hereditary disorders that include chorea-acanthocytosis (ChAc) and McLeod syndrome (MLS). Recent findings Although molecular defects associated with neuroacanthocytosis have been identified recently, their pathophysiology and the related RBC abnormalities are largely unknown. Studies in ChAc RBCs have shown an altered association between the cytoskeleton and the integral membrane protein compartment in the absence of major changes in RBC membrane composition. In ChAc RBCs, abnormal Lyn kinase activation in a Syk-independent fashion has been reported recently, resulting in increased band 3 tyrosine phosphorylation and perturbation of the stability of the multiprotein band 3-based complexes bridging the membrane to the spectrin-based membrane skeleton. Similarly, in MLS, the absence of XK-protein, which is associated with the spectrin–actin–4.1 junctional complex, is associated with an abnormal membrane protein phosphorylation state, with destabilization of the membrane skeletal network resulting in generation of acanthocytes. Summary A novel mechanism in generation of acanthocytes involving abnormal Lyn activation, identified in ChAc, expands the acanthocytosis phenomenon toward protein–protein interactions, controlled by phosphorylation-related abnormal signaling." @default.
• W2107201375 created "2016-06-24" @default.
• W2107201375 creator A5017035150 @default.
• W2107201375 creator A5034746599 @default.
• W2107201375 creator A5043729712 @default.
• W2107201375 date "2014-05-01" @default.
• W2107201375 modified "2023-09-26" @default.
• W2107201375 title "Abnormal red cell features associated with hereditary neurodegenerative disorders" @default.
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• W2107201375 cites W1578475287 @default.
• W2107201375 cites W1964754309 @default.
• W2107201375 cites W1966802114 @default.
• W2107201375 cites W1967455040 @default.
• W2107201375 cites W1970374784 @default.
• W2107201375 cites W1972979406 @default.
• W2107201375 cites W1973284660 @default.
• W2107201375 cites W1973745282 @default.
• W2107201375 cites W1974047098 @default.
• W2107201375 cites W1975119431 @default.
• W2107201375 cites W1981201486 @default.
• W2107201375 cites W1987022943 @default.
• W2107201375 cites W1988592980 @default.
• W2107201375 cites W1991112683 @default.
• W2107201375 cites W1992624274 @default.
• W2107201375 cites W1994333666 @default.
• W2107201375 cites W1995972883 @default.
• W2107201375 cites W1997995970 @default.
• W2107201375 cites W2001079520 @default.
• W2107201375 cites W2004778528 @default.
• W2107201375 cites W2005974899 @default.
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• W2107201375 cites W2010492051 @default.
• W2107201375 cites W2010790855 @default.
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• W2107201375 cites W2019531483 @default.
• W2107201375 cites W2021450321 @default.
• W2107201375 cites W2022066534 @default.
• W2107201375 cites W2023218652 @default.
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• W2107201375 cites W2052020421 @default.
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• W2107201375 cites W2055130175 @default.
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• W2107201375 doi "https://doi.org/10.1097/moh.0000000000000035" @default.
• W2107201375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24626044" @default.
• W2107201375 hasPublicationYear "2014" @default.
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