FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107201501> ?p ?o ?g. }

• W2107201501 abstract "Abstract Objectives The aim of this study was to prepare a disintegrating gastric floating tablet composed of floating pellets coated with acrylic resin to prolong the gastric residence time and increase the oral bioavailability of famotidine. Methods The gastric floating pellets containing famotidine, stearyl alcohol and microcrystalline cellulose (1 : 10 : 1) were prepared by extrusion–spheronization process and coated with acrylic resin, then compressed into tablets with Avicel PH 301 pellets and cross-linked polyvinylpyrrolidone. The coating weight, volume ratio of Eudragit RL30 D and RS30 D and solid content of coating fluid were optimized by Box–Behnken design. Key findings In 0.1 M HCl, tablets can immediately disintegrate into pellets which can remain floating and sustained drug releasing over 12 h. The AUC0-∞ of famotidine gastric floating pellets (7776.52 ± 1065.93 h ng/ml) administered into rats was significantly higher than that of marketed rapid release tablets Xingfading® (Xingyi, Shanghai, China) (4166.23 ± 312.43 h ng/ml), while the relative bioavailability was 187.01 ± 22.81%. Conclusions The experimental results indicated that the optimized formulation did offer a new gastro retention and sustained release approach to enhance the oral absorption of famotidine." @default.
• W2107201501 created "2016-06-24" @default.
• W2107201501 creator A5007828280 @default.
• W2107201501 creator A5029393450 @default.
• W2107201501 creator A5060312536 @default.
• W2107201501 creator A5067138179 @default.
• W2107201501 date "2014-12-10" @default.
• W2107201501 modified "2023-10-16" @default.
• W2107201501 title "Tablets compressed with gastric floating pellets coated with acrylic resin for gastro retention and sustained release of famotidine: in-vitro and in-vivo study" @default.
• W2107201501 cites W1527808116 @default.
• W2107201501 cites W1535521637 @default.
• W2107201501 cites W1964199329 @default.
• W2107201501 cites W1980048385 @default.
• W2107201501 cites W2006546507 @default.
• W2107201501 cites W2012880933 @default.
• W2107201501 cites W2015227577 @default.
• W2107201501 cites W2015270488 @default.
• W2107201501 cites W2034092700 @default.
• W2107201501 cites W2034144694 @default.
• W2107201501 cites W2036116861 @default.
• W2107201501 cites W2041773665 @default.
• W2107201501 cites W2042433785 @default.
• W2107201501 cites W2053162504 @default.
• W2107201501 cites W2053994461 @default.
• W2107201501 cites W2054420772 @default.
• W2107201501 cites W2061202596 @default.
• W2107201501 cites W2061756683 @default.
• W2107201501 cites W2065668696 @default.
• W2107201501 cites W2087526401 @default.
• W2107201501 cites W2148183546 @default.
• W2107201501 cites W2166580946 @default.
• W2107201501 cites W2171601916 @default.
• W2107201501 doi "https://doi.org/10.1111/jphp.12339" @default.
• W2107201501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25495700" @default.
• W2107201501 hasPublicationYear "2014" @default.
• W2107201501 type Work @default.
• W2107201501 sameAs 2107201501 @default.
• W2107201501 citedByCount "8" @default.
• W2107201501 countsByYear W21072015012015 @default.
• W2107201501 countsByYear W21072015012016 @default.
• W2107201501 countsByYear W21072015012018 @default.
• W2107201501 countsByYear W21072015012019 @default.
• W2107201501 crossrefType "journal-article" @default.
• W2107201501 hasAuthorship W2107201501A5007828280 @default.
• W2107201501 hasAuthorship W2107201501A5029393450 @default.
• W2107201501 hasAuthorship W2107201501A5060312536 @default.
• W2107201501 hasAuthorship W2107201501A5067138179 @default.
• W2107201501 hasBestOaLocation W21072015011 @default.
• W2107201501 hasConcept C140013486 @default.
• W2107201501 hasConcept C159985019 @default.
• W2107201501 hasConcept C178790620 @default.
• W2107201501 hasConcept C17923525 @default.
• W2107201501 hasConcept C181389837 @default.
• W2107201501 hasConcept C185592680 @default.
• W2107201501 hasConcept C188027245 @default.
• W2107201501 hasConcept C192562407 @default.
• W2107201501 hasConcept C2776634624 @default.
• W2107201501 hasConcept C2779251873 @default.
• W2107201501 hasConcept C2779351475 @default.
• W2107201501 hasConcept C2780077769 @default.
• W2107201501 hasConcept C2780584874 @default.
• W2107201501 hasConcept C2781218482 @default.
• W2107201501 hasConcept C2781263782 @default.
• W2107201501 hasConcept C2781448156 @default.
• W2107201501 hasConcept C3018292220 @default.
• W2107201501 hasConcept C43617362 @default.
• W2107201501 hasConcept C521977710 @default.
• W2107201501 hasConcept C71924100 @default.
• W2107201501 hasConcept C77281830 @default.
• W2107201501 hasConcept C98274493 @default.
• W2107201501 hasConceptScore W2107201501C140013486 @default.
• W2107201501 hasConceptScore W2107201501C159985019 @default.
• W2107201501 hasConceptScore W2107201501C178790620 @default.
• W2107201501 hasConceptScore W2107201501C17923525 @default.
• W2107201501 hasConceptScore W2107201501C181389837 @default.
• W2107201501 hasConceptScore W2107201501C185592680 @default.
• W2107201501 hasConceptScore W2107201501C188027245 @default.
• W2107201501 hasConceptScore W2107201501C192562407 @default.
• W2107201501 hasConceptScore W2107201501C2776634624 @default.
• W2107201501 hasConceptScore W2107201501C2779251873 @default.
• W2107201501 hasConceptScore W2107201501C2779351475 @default.
• W2107201501 hasConceptScore W2107201501C2780077769 @default.
• W2107201501 hasConceptScore W2107201501C2780584874 @default.
• W2107201501 hasConceptScore W2107201501C2781218482 @default.
• W2107201501 hasConceptScore W2107201501C2781263782 @default.
• W2107201501 hasConceptScore W2107201501C2781448156 @default.
• W2107201501 hasConceptScore W2107201501C3018292220 @default.
• W2107201501 hasConceptScore W2107201501C43617362 @default.
• W2107201501 hasConceptScore W2107201501C521977710 @default.
• W2107201501 hasConceptScore W2107201501C71924100 @default.
• W2107201501 hasConceptScore W2107201501C77281830 @default.
• W2107201501 hasConceptScore W2107201501C98274493 @default.
• W2107201501 hasFunder F4320321001 @default.
• W2107201501 hasFunder F4320322769 @default.
• W2107201501 hasLocation W21072015011 @default.
• W2107201501 hasLocation W21072015012 @default.
• W2107201501 hasOpenAccess W2107201501 @default.
• W2107201501 hasPrimaryLocation W21072015011 @default.
• W2107201501 hasRelatedWork W1575700777 @default.
• W2107201501 hasRelatedWork W1988645318 @default.

• next