FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107206572> ?p ?o ?g. }

• W2107206572 endingPage "5832" @default.
• W2107206572 startingPage "5823" @default.
• W2107206572 abstract "Human La protein has been shown to serve as a transcription factor for RNA polymerase III (pol III) by facilitating transcription termination and recycling of transcription complexes. In addition, La binds to the 3′ oligo(U) ends common to all nascent pol III transcripts, and in the case of B1-Alu RNA, protects it from 3′-end processing (R. J. Maraia, D. J. Kenan, and J. D. Keene, Mol. Cell. Biol. 14:2147–2158, 1994). Others have previously dissected the La protein into an N-terminal domain that binds RNA and a C-terminal domain that does not. Here, deletion and substitution mutants of La were examined for general RNA binding, RNA 3′-end protection, and transcription factor activity. Although some La mutants altered in a C-terminal basic region bind RNA in mobility shift assays, they are defective in RNA 3′-end protection and do not support transcription, while one C-terminal substitution mutant is defective only in transcription. Moreover, a C-terminal fragment lacking RNA binding activity appears able to support low levels of transcription by pol III. While efficient multiround transcription is supported only by mutants that bind RNA and contain a C-terminal basic region. These analyses indicate that RNA binding contributes to but is not sufficient for La transcription factor activity and that the C-terminal domain plays a role in transcription that is distinguishable from simple RNA binding. The transcription factor activity of La can be reversibly inhibited by RNA, suggesting the potential for feedback inhibition of pol III transcription." @default.
• W2107206572 created "2016-06-24" @default.
• W2107206572 creator A5046036216 @default.
• W2107206572 creator A5049076723 @default.
• W2107206572 creator A5080411990 @default.
• W2107206572 date "1997-10-01" @default.
• W2107206572 modified "2023-10-13" @default.
• W2107206572 title "A Carboxy-Terminal Basic Region Controls RNA Polymerase III Transcription Factor Activity of Human La Protein" @default.
• W2107206572 cites W1547123197 @default.
• W2107206572 cites W1559116353 @default.
• W2107206572 cites W1577649568 @default.
• W2107206572 cites W1602300034 @default.
• W2107206572 cites W1636692352 @default.
• W2107206572 cites W1876905084 @default.
• W2107206572 cites W1880398223 @default.
• W2107206572 cites W1972579277 @default.
• W2107206572 cites W1976732266 @default.
• W2107206572 cites W1984783168 @default.
• W2107206572 cites W2006624258 @default.
• W2107206572 cites W2006630070 @default.
• W2107206572 cites W2018924496 @default.
• W2107206572 cites W2022149623 @default.
• W2107206572 cites W2024651141 @default.
• W2107206572 cites W2031508888 @default.
• W2107206572 cites W2048882741 @default.
• W2107206572 cites W2054766409 @default.
• W2107206572 cites W2072927794 @default.
• W2107206572 cites W2073932060 @default.
• W2107206572 cites W2076849957 @default.
• W2107206572 cites W2077248019 @default.
• W2107206572 cites W2079559236 @default.
• W2107206572 cites W2082825505 @default.
• W2107206572 cites W2099940931 @default.
• W2107206572 cites W210302837 @default.
• W2107206572 cites W2104194135 @default.
• W2107206572 cites W2108177402 @default.
• W2107206572 cites W2109448523 @default.
• W2107206572 cites W2137634127 @default.
• W2107206572 cites W2141216907 @default.
• W2107206572 cites W284187410 @default.
• W2107206572 cites W2888511473 @default.
• W2107206572 cites W29372789 @default.
• W2107206572 cites W4250467272 @default.
• W2107206572 doi "https://doi.org/10.1128/mcb.17.10.5823" @default.
• W2107206572 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/232430" @default.
• W2107206572 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9315640" @default.
• W2107206572 hasPublicationYear "1997" @default.
• W2107206572 type Work @default.
• W2107206572 sameAs 2107206572 @default.
• W2107206572 citedByCount "67" @default.
• W2107206572 countsByYear W21072065722012 @default.
• W2107206572 countsByYear W21072065722013 @default.
• W2107206572 countsByYear W21072065722014 @default.
• W2107206572 countsByYear W21072065722015 @default.
• W2107206572 countsByYear W21072065722016 @default.
• W2107206572 countsByYear W21072065722017 @default.
• W2107206572 countsByYear W21072065722018 @default.
• W2107206572 countsByYear W21072065722019 @default.
• W2107206572 countsByYear W21072065722020 @default.
• W2107206572 crossrefType "journal-article" @default.
• W2107206572 hasAuthorship W2107206572A5046036216 @default.
• W2107206572 hasAuthorship W2107206572A5049076723 @default.
• W2107206572 hasAuthorship W2107206572A5080411990 @default.
• W2107206572 hasBestOaLocation W21072065721 @default.
• W2107206572 hasConcept C101762097 @default.
• W2107206572 hasConcept C104317684 @default.
• W2107206572 hasConcept C105208137 @default.
• W2107206572 hasConcept C111936080 @default.
• W2107206572 hasConcept C138885662 @default.
• W2107206572 hasConcept C144825837 @default.
• W2107206572 hasConcept C146027311 @default.
• W2107206572 hasConcept C150194340 @default.
• W2107206572 hasConcept C153911025 @default.
• W2107206572 hasConcept C154816499 @default.
• W2107206572 hasConcept C156951783 @default.
• W2107206572 hasConcept C172768829 @default.
• W2107206572 hasConcept C179926584 @default.
• W2107206572 hasConcept C196117886 @default.
• W2107206572 hasConcept C25281209 @default.
• W2107206572 hasConcept C41258723 @default.
• W2107206572 hasConcept C41895202 @default.
• W2107206572 hasConcept C54355233 @default.
• W2107206572 hasConcept C64350747 @default.
• W2107206572 hasConcept C67705224 @default.
• W2107206572 hasConcept C86339819 @default.
• W2107206572 hasConcept C86803240 @default.
• W2107206572 hasConceptScore W2107206572C101762097 @default.
• W2107206572 hasConceptScore W2107206572C104317684 @default.
• W2107206572 hasConceptScore W2107206572C105208137 @default.
• W2107206572 hasConceptScore W2107206572C111936080 @default.
• W2107206572 hasConceptScore W2107206572C138885662 @default.
• W2107206572 hasConceptScore W2107206572C144825837 @default.
• W2107206572 hasConceptScore W2107206572C146027311 @default.
• W2107206572 hasConceptScore W2107206572C150194340 @default.
• W2107206572 hasConceptScore W2107206572C153911025 @default.
• W2107206572 hasConceptScore W2107206572C154816499 @default.
• W2107206572 hasConceptScore W2107206572C156951783 @default.
• W2107206572 hasConceptScore W2107206572C172768829 @default.

• next