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- W2107208637 abstract "Abstract Stem cells belong to a unique class of cells that is collectively responsible for the development and subsequent maintenance of all tissues comprising multicellular organisms. These cells possess unique characteristics that allow them to remain in a pluripotent state, while also continuing to generate differentiated cells. microRNAs, a specialized class of non-coding RNAs, are integral components of the network of pathways that modulates this combination of abilities. This review highlights recent discoveries about the roles miRNAs play in governing stem cell phenotype, and discusses the potential therapeutic utility that miRNAs may have in the treatment of multiple diseases. Additionally, it addresses a novel mode of regulation of stem cell phenotype through lincRNA-mediated modulation of select miRNAs, and the role of secreted, stem cell-derived miRNAs in exerting a paracrine influence on surrounding non-stem cells." @default.
- W2107208637 created "2016-06-24" @default.
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- W2107208637 date "2014-01-17" @default.
- W2107208637 modified "2023-09-25" @default.
- W2107208637 title "miRNA function and modulation in stem cells and cancer stem cells" @default.
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- W2107208637 doi "https://doi.org/10.2478/micrnat-2014-0004" @default.
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