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• W2107222529 abstract "Novel quinoxalinone derivatives were synthesized and tested for their inhibitory activity against aldose reductase. Among them, N1-acetate derivatives had significant activity in a range of IC50 values from low micromolar to submicromolar, and compound 15a bearing a C3-phenethyl side chain was identified as the most potent inhibitor with an IC50 value of 0.143 μM. The structure-activity studies suggested that both C3-phenethyl and C6-NO2 groups play an important role in enhancing the activity and selectivity of the quinoxalinone based inhibitors." @default.
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• W2107222529 date "2014-06-01" @default.
• W2107222529 modified "2023-10-02" @default.
• W2107222529 title "Structure–activity relationships studies of quinoxalinone derivatives as aldose reductase inhibitors" @default.
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• W2107222529 doi "https://doi.org/10.1016/j.ejmech.2014.04.047" @default.
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