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- W2107251344 abstract "Summary Thyroid hormones (THs) have been shown to improve in vitro embryo production in cattle by increasing blastocyst formation rate, and the average cell number of blastocysts and by significantly decreasing apoptosis rate. To better understand those genetic aspects that may underlie enhanced early embryo development in the presence of THs, we characterized the bovine embryonic transcriptome at the blastocyst stage, and examined differential gene expression profiles using a bovine-specific microarray. We found that 1212 genes were differentially expressed in TH-treated embryos when compared with non-treated controls (>1.5-fold at P < 0.05). In addition 23 and eight genes were expressed uniquely in control and treated embryos, respectively. The expression of genes specifically associated with metabolism, mitochondrial function, cell differentiation and development were elevated. However, TH-related genes, including those encoding TH receptors and deiodinases, were not differentially expressed in treated embryos. Furthermore, the over-expression of 52 X-chromosome linked genes in treated embryos suggested a delay or escape from X-inactivation. This study highlights the significant impact of THs on differential gene expression in the early embryo; the identification of TH-responsive genes provides an insight into those regulatory pathways activated during development." @default.
- W2107251344 created "2016-06-24" @default.
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- W2107251344 date "2015-06-23" @default.
- W2107251344 modified "2023-09-27" @default.
- W2107251344 title "Thyroid hormones alter the transcriptome of in vitro-produced bovine blastocysts" @default.
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- W2107251344 cites W1968090280 @default.
- W2107251344 cites W1971564082 @default.
- W2107251344 cites W1978565769 @default.
- W2107251344 cites W1980548655 @default.
- W2107251344 cites W1982465562 @default.
- W2107251344 cites W1984717527 @default.
- W2107251344 cites W1994196058 @default.
- W2107251344 cites W1998105966 @default.
- W2107251344 cites W2000915541 @default.
- W2107251344 cites W2004451132 @default.
- W2107251344 cites W2005203311 @default.
- W2107251344 cites W2007132345 @default.
- W2107251344 cites W2009410786 @default.
- W2107251344 cites W2015314347 @default.
- W2107251344 cites W2021932599 @default.
- W2107251344 cites W2025525606 @default.
- W2107251344 cites W2031545497 @default.
- W2107251344 cites W2035162346 @default.
- W2107251344 cites W2045423466 @default.
- W2107251344 cites W2046282038 @default.
- W2107251344 cites W2049320863 @default.
- W2107251344 cites W2053829558 @default.
- W2107251344 cites W2054280836 @default.
- W2107251344 cites W2058715647 @default.
- W2107251344 cites W2060325240 @default.
- W2107251344 cites W2063674189 @default.
- W2107251344 cites W2064079301 @default.
- W2107251344 cites W2071067626 @default.
- W2107251344 cites W2077481451 @default.
- W2107251344 cites W2078895122 @default.
- W2107251344 cites W2082214848 @default.
- W2107251344 cites W2084287047 @default.
- W2107251344 cites W2084793610 @default.
- W2107251344 cites W2085779184 @default.
- W2107251344 cites W2088689128 @default.
- W2107251344 cites W2089164938 @default.
- W2107251344 cites W2093680564 @default.
- W2107251344 cites W2094795565 @default.
- W2107251344 cites W2099659034 @default.
- W2107251344 cites W2102296508 @default.
- W2107251344 cites W2106410227 @default.
- W2107251344 cites W2107264407 @default.
- W2107251344 cites W2109789019 @default.
- W2107251344 cites W2109937387 @default.
- W2107251344 cites W2114854528 @default.
- W2107251344 cites W2115610821 @default.
- W2107251344 cites W2115940794 @default.
- W2107251344 cites W2118498634 @default.
- W2107251344 cites W2118969289 @default.
- W2107251344 cites W2121774339 @default.
- W2107251344 cites W2122753647 @default.
- W2107251344 cites W2126344551 @default.
- W2107251344 cites W2128199185 @default.
- W2107251344 cites W2136386420 @default.
- W2107251344 cites W2139041157 @default.
- W2107251344 cites W2141916608 @default.
- W2107251344 cites W2142695851 @default.
- W2107251344 cites W2148797402 @default.
- W2107251344 cites W2149548143 @default.
- W2107251344 cites W2150341966 @default.
- W2107251344 cites W2152615865 @default.
- W2107251344 cites W2158723358 @default.
- W2107251344 cites W2160273500 @default.
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- W2107251344 cites W2162860583 @default.
- W2107251344 cites W2163580927 @default.
- W2107251344 cites W2165877506 @default.
- W2107251344 cites W2181542280 @default.
- W2107251344 cites W2319975299 @default.
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- W2107251344 doi "https://doi.org/10.1017/s0967199415000167" @default.
- W2107251344 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26099992" @default.
- W2107251344 hasPublicationYear "2015" @default.
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