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• W2107256687 abstract "Ongoing investigations evaluated clinically relevant properties of BOTOX® (botulinum toxin type A) relative to other botulinum neurotoxin preparations based on the same (type A) or different (types B, C, E and F) serotypes. The mouse Digit Abduction Scoring (DAS) assay was used to compare muscle weakening efficacy, the antigenic potential of two BOTOX® preparations was measured in rabbits, and the presence of antibodies to serotypes A and B was analysed in humans. BOTOX® and new BOTOX® produced similar degrees of dose‐related muscle weakness in mice. Both preparations of BOTOX® were approximately four times more potent than Dysport®. Preparations of serotypes B, C, and F also demonstrated lower potency than BOTOX®, with serotype F also having a shorter duration of action. Neutralising antibodies were found in rabbits 3 months post‐treatment with BOTOX®, but were undetected 8 months post‐treatment with new BOTOX®. A high incidence of antibodies to type B was observed in individuals with no known exposure to type B toxin: highest in groups with the highest incidence of type A antibodies. The safety margin for BOTOX®, calculated using DAS median effective dose (ED,) and the minimum dose producing a 10% reduction in body weight, was more than twice that of Dysport®. In conclusion, each botulinum toxin serotype tested exhibited a different muscle weakening efficacy; BOTOX® consistently exhibited the greatest eficacy. Importantly, BOTOX® and Dysport® exhibited markedly different efficacy and safety profiles, and should not be considered interchangeable. Antibody distribution in humans suggests that there may be immunological cross‐reactivity between serotypes A and B." @default.
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• W2107256687 date "1999-11-01" @default.
• W2107256687 modified "2023-10-18" @default.
• W2107256687 title "Preclinical update on BOTOX® (botulinum toxin type A)‐purified neurotoxin complex relative to other botulinurn neurotoxin preparations" @default.
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• W2107256687 doi "https://doi.org/10.1111/j.1468-1331.1999.tb00032.x" @default.
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