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• W2107261948 abstract "4-Arylpyrano-[3,2-c]-pyridones have been prepared by a one-step cyclocondensation of 4-hydroxy-1,6-dimethylpyridin-2(1H)-one with various substituted benzaldehydes and malononitrile. These heterocycles exhibit micromolar and submicromolar antiproliferative activity in HeLa and induce apoptosis in Jurkat cell lines. Structure-activity studies performed on a small library of these compounds show a pronounced cytotoxicity enhancing effect of the bromo substituent at the meta position of the C4 aromatic moiety." @default.
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• W2107261948 date "2007-07-01" @default.
• W2107261948 modified "2023-10-14" @default.
• W2107261948 title "Antiproliferative and apoptosis inducing properties of pyrano[3,2-c]pyridones accessible by a one-step multicomponent synthesis" @default.
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• W2107261948 doi "https://doi.org/10.1016/j.bmcl.2007.05.004" @default.
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