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- W2107263453 abstract "Drug delivery via oral mucosa is an alternative method of systemic administration for various classes of therapeutic agents. Among the oral mucosae, buccal and sublingual mucosae are the primary focus for drug delivery. Buccal delivery offers a clear advantage over the peroral route by avoidance of intestinal and hepatic first-pass metabolism. However, despite offering the possibility of improved systemic drug delivery, buccal administration has been utilized for relatively few pharmaceutical products so far. One of the major limitations associated with buccal delivery is low permeation of therapeutic agents across the mucosa. Various substances have been explored as permeation enhancers to increase the flux/absorption of drugs through the mucosa, but irritation, membrane damage, and toxicity are always associated with them and limit their use. A clinically accepted permeation enhancer must increase membrane permeability without causing toxicity and permanent membrane damage. To date, the information available on oral mucosal permeation enhancement is much less than transdermal enhancement, though oral mucosa is more resistant to damage than other mucosal membranes. This article reviews the various categories of permeation enhancers for oral mucosal drug delivery, their mechanism of action, their usefulness, and the limitations associated with their use.To optimize the concentration of enhancer to limit its toxicity while facilitating an enhancing effect reproducibly will be a big challenge for future developments. Advances in permeability modulation and formulation with appropriate enhancers can provide for effective and feasible buccal drug delivery for many drugs, which otherwise have to be injected or ingested with water." @default.
- W2107263453 created "2016-06-24" @default.
- W2107263453 creator A5021275538 @default.
- W2107263453 creator A5064486168 @default.
- W2107263453 creator A5070503314 @default.
- W2107263453 creator A5077599012 @default.
- W2107263453 date "2009-08-07" @default.
- W2107263453 modified "2023-09-22" @default.
- W2107263453 title "Critical evaluation of permeation enhancers for oral mucosal drug delivery" @default.
- W2107263453 cites W106037107 @default.
- W2107263453 cites W1498725963 @default.
- W2107263453 cites W1511260511 @default.
- W2107263453 cites W1548751297 @default.
- W2107263453 cites W1548826219 @default.
- W2107263453 cites W1554181190 @default.
- W2107263453 cites W1568216484 @default.
- W2107263453 cites W1589692368 @default.
- W2107263453 cites W1595265868 @default.
- W2107263453 cites W161255469 @default.
- W2107263453 cites W162216843 @default.
- W2107263453 cites W164922229 @default.
- W2107263453 cites W168756651 @default.
- W2107263453 cites W194013273 @default.
- W2107263453 cites W1963653036 @default.
- W2107263453 cites W1963834984 @default.
- W2107263453 cites W1964340686 @default.
- W2107263453 cites W1965774657 @default.
- W2107263453 cites W1966324649 @default.
- W2107263453 cites W1967286971 @default.
- W2107263453 cites W1968885490 @default.
- W2107263453 cites W1969654223 @default.
- W2107263453 cites W1971288481 @default.
- W2107263453 cites W1973508542 @default.
- W2107263453 cites W1973607059 @default.
- W2107263453 cites W1973778878 @default.
- W2107263453 cites W1975460416 @default.
- W2107263453 cites W1975573939 @default.
- W2107263453 cites W1975652895 @default.
- W2107263453 cites W1975863776 @default.
- W2107263453 cites W1975887141 @default.
- W2107263453 cites W1979991026 @default.
- W2107263453 cites W1981645273 @default.
- W2107263453 cites W1982050288 @default.
- W2107263453 cites W1982051390 @default.
- W2107263453 cites W1984458006 @default.
- W2107263453 cites W1984572492 @default.
- W2107263453 cites W1984665113 @default.
- W2107263453 cites W1985763351 @default.
- W2107263453 cites W1986688861 @default.
- W2107263453 cites W1987644604 @default.
- W2107263453 cites W1988012147 @default.
- W2107263453 cites W1990820081 @default.
- W2107263453 cites W1992375050 @default.
- W2107263453 cites W1992401348 @default.
- W2107263453 cites W1993345718 @default.
- W2107263453 cites W1994324389 @default.
- W2107263453 cites W1994496949 @default.
- W2107263453 cites W1994508604 @default.
- W2107263453 cites W1995728313 @default.
- W2107263453 cites W1995760897 @default.
- W2107263453 cites W1997741232 @default.
- W2107263453 cites W1999303711 @default.
- W2107263453 cites W2000179637 @default.
- W2107263453 cites W2000542157 @default.
- W2107263453 cites W2002497242 @default.
- W2107263453 cites W2003215043 @default.
- W2107263453 cites W2004074383 @default.
- W2107263453 cites W2005874582 @default.
- W2107263453 cites W2006458202 @default.
- W2107263453 cites W2008165795 @default.
- W2107263453 cites W2008765645 @default.
- W2107263453 cites W2010865418 @default.
- W2107263453 cites W2011871558 @default.
- W2107263453 cites W2011873005 @default.
- W2107263453 cites W2012412352 @default.
- W2107263453 cites W2013052289 @default.
- W2107263453 cites W2013062743 @default.
- W2107263453 cites W2013783514 @default.
- W2107263453 cites W2013802847 @default.
- W2107263453 cites W2014638300 @default.
- W2107263453 cites W2015048289 @default.
- W2107263453 cites W2015151010 @default.
- W2107263453 cites W2015454561 @default.
- W2107263453 cites W2015911538 @default.
- W2107263453 cites W2017394696 @default.
- W2107263453 cites W2020096433 @default.
- W2107263453 cites W2023088935 @default.
- W2107263453 cites W2023134325 @default.
- W2107263453 cites W2023187823 @default.
- W2107263453 cites W2023464297 @default.
- W2107263453 cites W2024930256 @default.
- W2107263453 cites W2026237079 @default.
- W2107263453 cites W2028419626 @default.
- W2107263453 cites W2028902578 @default.
- W2107263453 cites W2029438930 @default.
- W2107263453 cites W2030945141 @default.
- W2107263453 cites W2031779700 @default.
- W2107263453 cites W2033545969 @default.
- W2107263453 cites W2035119862 @default.
- W2107263453 cites W2035868328 @default.