FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107271303> ?p ?o ?g. }

• W2107271303 endingPage "426" @default.
• W2107271303 startingPage "419" @default.
• W2107271303 abstract "There is evidence that the basis of an atopic-skewed immune response is acquired early in life, perhaps at the fetal stage. Thus, we hypothesized that the development of the fetal immune system might be influenced by maternal regulatory T cells (Treg) and maternal T cell cytokine production during pregnancy. The aim of the present study was to assess the influence of maternal Treg and cytokine production during pregnancy on Treg and atopy at birth.Within the mother-child study LINA (Lifestyle and Environmental factors and their Influence on Newborns Allergy risk), we determined the frequency and function of Treg and the total IgE concentration in pregnant women in the 34th week of gestation and in corresponding cord bloods at birth (n=24). Furthermore, we assessed how maternal mitogen-induced T-helper type 1/T-helper type 2 and inflammatory cytokines influence the level of cord blood Treg and IgE.Frequencies of CD4(+)CD25(high) T cells were higher (P=0.001), whereas percentages of FOXP3+ T cells were lower (P<0.001) in cord blood cells compared with maternal blood. Reduced maternal CD4(+)CD25(high) Treg frequencies correlated with increased total IgE concentrations at the 34th week of gestation (r=-0.32, P=0.028) and with increased IgE concentrations in cord blood (r=-0.50, P<0.001). Elevated maternal mitogen-induced Th2 cytokine production was related to increased total IgE levels in the serum of corresponding cord bloods (IL-4, r=0.53; IL-5, r=0.43; IL-13, r=0.52).Because cord blood IgE has been shown to be predictive for allergic diseases in early childhood, our results indicate that reduced maternal Treg numbers and increased Th2 cytokine production during pregnancy might influence the allergy risk of the child." @default.
• W2107271303 created "2016-06-24" @default.
• W2107271303 creator A5004446285 @default.
• W2107271303 creator A5045146753 @default.
• W2107271303 creator A5050816060 @default.
• W2107271303 creator A5053009993 @default.
• W2107271303 creator A5056448954 @default.
• W2107271303 creator A5062555886 @default.
• W2107271303 creator A5064320404 @default.
• W2107271303 creator A5067359070 @default.
• W2107271303 creator A5079306848 @default.
• W2107271303 date "2010-03-01" @default.
• W2107271303 modified "2023-10-12" @default.
• W2107271303 title "Reduced maternal regulatory T cell numbers and increased T helper type 2 cytokine production are associated with elevated levels of immunoglobulin E in cord blood" @default.
• W2107271303 cites W1487602178 @default.
• W2107271303 cites W1497240165 @default.
• W2107271303 cites W1970091316 @default.
• W2107271303 cites W1982175457 @default.
• W2107271303 cites W1984782468 @default.
• W2107271303 cites W1991051577 @default.
• W2107271303 cites W1999866766 @default.
• W2107271303 cites W2007286155 @default.
• W2107271303 cites W2022196368 @default.
• W2107271303 cites W2025562064 @default.
• W2107271303 cites W2026628287 @default.
• W2107271303 cites W2039062116 @default.
• W2107271303 cites W2039756952 @default.
• W2107271303 cites W2040304576 @default.
• W2107271303 cites W2041302559 @default.
• W2107271303 cites W2043415982 @default.
• W2107271303 cites W2047092800 @default.
• W2107271303 cites W2058334478 @default.
• W2107271303 cites W2060297561 @default.
• W2107271303 cites W2066521804 @default.
• W2107271303 cites W2071787753 @default.
• W2107271303 cites W2072066004 @default.
• W2107271303 cites W2089709635 @default.
• W2107271303 cites W2089971935 @default.
• W2107271303 cites W2113852532 @default.
• W2107271303 cites W2121059516 @default.
• W2107271303 cites W2124133622 @default.
• W2107271303 cites W2139201574 @default.
• W2107271303 cites W2147781011 @default.
• W2107271303 cites W2148226248 @default.
• W2107271303 cites W2156964052 @default.
• W2107271303 cites W2161044344 @default.
• W2107271303 cites W2166235600 @default.
• W2107271303 cites W2168628806 @default.
• W2107271303 doi "https://doi.org/10.1111/j.1365-2222.2009.03434.x" @default.
• W2107271303 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20067477" @default.
• W2107271303 hasPublicationYear "2010" @default.
• W2107271303 type Work @default.
• W2107271303 sameAs 2107271303 @default.
• W2107271303 citedByCount "30" @default.
• W2107271303 countsByYear W21072713032012 @default.
• W2107271303 countsByYear W21072713032013 @default.
• W2107271303 countsByYear W21072713032014 @default.
• W2107271303 countsByYear W21072713032015 @default.
• W2107271303 countsByYear W21072713032016 @default.
• W2107271303 countsByYear W21072713032017 @default.
• W2107271303 countsByYear W21072713032018 @default.
• W2107271303 countsByYear W21072713032021 @default.
• W2107271303 countsByYear W21072713032022 @default.
• W2107271303 countsByYear W21072713032023 @default.
• W2107271303 crossrefType "journal-article" @default.
• W2107271303 hasAuthorship W2107271303A5004446285 @default.
• W2107271303 hasAuthorship W2107271303A5045146753 @default.
• W2107271303 hasAuthorship W2107271303A5050816060 @default.
• W2107271303 hasAuthorship W2107271303A5053009993 @default.
• W2107271303 hasAuthorship W2107271303A5056448954 @default.
• W2107271303 hasAuthorship W2107271303A5062555886 @default.
• W2107271303 hasAuthorship W2107271303A5064320404 @default.
• W2107271303 hasAuthorship W2107271303A5067359070 @default.
• W2107271303 hasAuthorship W2107271303A5079306848 @default.
• W2107271303 hasConcept C126322002 @default.
• W2107271303 hasConcept C141105273 @default.
• W2107271303 hasConcept C159654299 @default.
• W2107271303 hasConcept C172680121 @default.
• W2107271303 hasConcept C203014093 @default.
• W2107271303 hasConcept C207480886 @default.
• W2107271303 hasConcept C2776090121 @default.
• W2107271303 hasConcept C2777697326 @default.
• W2107271303 hasConcept C2778296632 @default.
• W2107271303 hasConcept C2778690821 @default.
• W2107271303 hasConcept C2779234561 @default.
• W2107271303 hasConcept C2779727006 @default.
• W2107271303 hasConcept C2780914630 @default.
• W2107271303 hasConcept C46973012 @default.
• W2107271303 hasConcept C54355233 @default.
• W2107271303 hasConcept C71924100 @default.
• W2107271303 hasConcept C79484868 @default.
• W2107271303 hasConcept C86803240 @default.
• W2107271303 hasConcept C8891405 @default.
• W2107271303 hasConceptScore W2107271303C126322002 @default.
• W2107271303 hasConceptScore W2107271303C141105273 @default.
• W2107271303 hasConceptScore W2107271303C159654299 @default.
• W2107271303 hasConceptScore W2107271303C172680121 @default.
• W2107271303 hasConceptScore W2107271303C203014093 @default.

• next