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- W2107284702 abstract "Gastroduodenal ulceration is found in 90% of Thoroughbred race horses. The clinical and economical imp ortance of gastric ulcers and the scarce information about the subject in Brazil make this investigation essen tial. The aim of this study was to evaluate and map grossly and microscopically the gastroduodenal lesions in race horses ac cording to the Updated Sidney System and the Equine Gastric Ulcer Syndrome Council (EGUSC) Classification. Necropsy was performed in 14 horses and macroscopy was described. Samples of the gastric regions (14 animals - nonglandular f undus, glandular fundus, margo plicatus, antrum and pylorus) and duo denum (9 animals) were obtained and processed for routine histopathology. Macroscopic evaluation of the lesio ns based on the Updated Sidney System showed that 100% of the horses had gastric ulcers or erosions, mainly located at t he margo plicatus. The Updated Sidney System also allowed a macroscopic gastritis classification and revealed t hat seven horses had enanthematous gastritis (50%), four had hemorrhagic gastritis (28, 6%), and three had erosive gastritis (21, 4%). Based on the EGUSC Classification, the most frequent score is 2 (50%). The score 3 was found in 35,7% of the horses and the scores 1 and 4 in 7,1% each. The score 0 w hich means intact epithelium, was not seen in any of the horses. Hist opathological evaluation based on the Updated Sidney System revealed mild to severe lymphoplasmacytic infiltrate, someti mes with areas of neutrophilic infiltrate, demonstr ating some activity mainly in the injured mucosa. Lymphoid follicles were found in 92.9% of the animals. This study confir ms that gastric ulceration in Brazilian race horses is common, and the majority consists of chronic ulceration of the margo plicatus. The use of the histopathological division of the Updated Si dney System demonstrated that chronic gastritis was predominant and the majority of cells in the inflammatory infiltrate we re lymphocytes and plasmocytes. This study also sho wed that the association of the Updated Sidney System and the EGUSC Classification is feasible and leads to a bette r understanding of equine gastroduodenal ulceration. Although usually neglected, these lesions may be involved in low per formance rates and therefore other investigations are necessary for th e elucidation of the etiology and pathogenesis of t hese ulcers." @default.
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- W2107284702 date "2012-01-01" @default.
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- W2107284702 title "Gastroduodenal Lesions in Racehorses: Evaluation and Mapping According to the Updated Sidney System and Equine Gastric Ulcer Syndrome Council Classification" @default.
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