FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107293885> ?p ?o ?g. }

• W2107293885 endingPage "706" @default.
• W2107293885 startingPage "701" @default.
• W2107293885 abstract "We previously reported that acute incubation with tetrahydrobiopterin (BH4) or sepiapterin, a cofactor for endothelial nitric oxide synthase and a stable precursor of BH4, respectively, enhanced the acetylcholine (Ach)-induced relaxation of isolated small mesenteric arteries (SMA) from diabetic (db/db) mice. In this study, we investigated the effect of chronic oral supplementation of sepiapterin (10 mg x kg-1 x day-1) to db/db mice on endothelium function, biopterin levels and lipid peroxidation in SMA. Oral dietary supplementation with sepiapterin had no effect on glucose, triglyceride, cholesterol levels and body weight. SMA from db/db mice showed enhanced vascular reactivity to phenylephrine, which was corrected with sepiapterin supplementation. Furthermore, Ach, but not sodium nitroprusside-induced relaxation, was improved with sepiapterin supplementation in db/db mice. BH4 levels and guanosine triphosphate cyclohydrolase I activity in SMA were similar in db/+ and db/db mice. Sepiapterin treatment had no effects on BH4 or guanosine triphosphate cyclohydrolase I activity. However, the level of dihydrobiopterin+biopterin was higher in SMA from db/db mice, which was corrected following sepiapterin treatment. Thiobarbituric acid reactive substance, malondialdehyde, a marker of lipid peroxidation, was higher in SMA from db/db mice, and was normalized by sepiapterin treatment. These results indicate that sepiapterin improves endothelial dysfunction in SMA from db/db mice by reducing oxidative stress. Furthermore, these results suggest that decreased biosynthesis of BH4 may not be the basis for endothelial dysfunction in SMA from db/db mice." @default.
• W2107293885 created "2016-06-24" @default.
• W2107293885 creator A5027977532 @default.
• W2107293885 creator A5043136683 @default.
• W2107293885 creator A5080334509 @default.
• W2107293885 creator A5084792115 @default.
• W2107293885 creator A5087318145 @default.
• W2107293885 date "2003-10-01" @default.
• W2107293885 modified "2023-10-12" @default.
• W2107293885 title "Chronic oral supplementation with sepiapterin prevents endothelial dysfunction and oxidative stress in small mesenteric arteries from diabetic (db/db) mice" @default.
• W2107293885 cites W1499812702 @default.
• W2107293885 cites W1917133058 @default.
• W2107293885 cites W1970728146 @default.
• W2107293885 cites W1974528590 @default.
• W2107293885 cites W1979424014 @default.
• W2107293885 cites W1982584549 @default.
• W2107293885 cites W1991638339 @default.
• W2107293885 cites W2011089437 @default.
• W2107293885 cites W2013529909 @default.
• W2107293885 cites W2029891724 @default.
• W2107293885 cites W2037854429 @default.
• W2107293885 cites W2048574237 @default.
• W2107293885 cites W2055870525 @default.
• W2107293885 cites W2058242086 @default.
• W2107293885 cites W2060717747 @default.
• W2107293885 cites W2071186420 @default.
• W2107293885 cites W2077941478 @default.
• W2107293885 cites W2079182225 @default.
• W2107293885 cites W2083481797 @default.
• W2107293885 cites W2092939065 @default.
• W2107293885 cites W2106121696 @default.
• W2107293885 cites W2117483991 @default.
• W2107293885 cites W2130401548 @default.
• W2107293885 cites W2133791947 @default.
• W2107293885 cites W2141998216 @default.
• W2107293885 cites W2158667023 @default.
• W2107293885 cites W2160057247 @default.
• W2107293885 cites W2161638887 @default.
• W2107293885 cites W2167927369 @default.
• W2107293885 cites W2409199200 @default.
• W2107293885 cites W4239090043 @default.
• W2107293885 cites W4241784603 @default.
• W2107293885 doi "https://doi.org/10.1038/sj.bjp.0705476" @default.
• W2107293885 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1574066" @default.
• W2107293885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14534153" @default.
• W2107293885 hasPublicationYear "2003" @default.
• W2107293885 type Work @default.
• W2107293885 sameAs 2107293885 @default.
• W2107293885 citedByCount "88" @default.
• W2107293885 countsByYear W21072938852012 @default.
• W2107293885 countsByYear W21072938852013 @default.
• W2107293885 countsByYear W21072938852014 @default.
• W2107293885 countsByYear W21072938852015 @default.
• W2107293885 countsByYear W21072938852016 @default.
• W2107293885 countsByYear W21072938852017 @default.
• W2107293885 countsByYear W21072938852018 @default.
• W2107293885 countsByYear W21072938852019 @default.
• W2107293885 countsByYear W21072938852020 @default.
• W2107293885 countsByYear W21072938852021 @default.
• W2107293885 countsByYear W21072938852022 @default.
• W2107293885 countsByYear W21072938852023 @default.
• W2107293885 crossrefType "journal-article" @default.
• W2107293885 hasAuthorship W2107293885A5027977532 @default.
• W2107293885 hasAuthorship W2107293885A5043136683 @default.
• W2107293885 hasAuthorship W2107293885A5080334509 @default.
• W2107293885 hasAuthorship W2107293885A5084792115 @default.
• W2107293885 hasAuthorship W2107293885A5087318145 @default.
• W2107293885 hasBestOaLocation W21072938852 @default.
• W2107293885 hasConcept C126322002 @default.
• W2107293885 hasConcept C134018914 @default.
• W2107293885 hasConcept C185592680 @default.
• W2107293885 hasConcept C2776145790 @default.
• W2107293885 hasConcept C2776151105 @default.
• W2107293885 hasConcept C2776820930 @default.
• W2107293885 hasConcept C2776992346 @default.
• W2107293885 hasConcept C2777451243 @default.
• W2107293885 hasConcept C2777622882 @default.
• W2107293885 hasConcept C2778401633 @default.
• W2107293885 hasConcept C2780771799 @default.
• W2107293885 hasConcept C2780829032 @default.
• W2107293885 hasConcept C2780972559 @default.
• W2107293885 hasConcept C519581460 @default.
• W2107293885 hasConcept C71924100 @default.
• W2107293885 hasConceptScore W2107293885C126322002 @default.
• W2107293885 hasConceptScore W2107293885C134018914 @default.
• W2107293885 hasConceptScore W2107293885C185592680 @default.
• W2107293885 hasConceptScore W2107293885C2776145790 @default.
• W2107293885 hasConceptScore W2107293885C2776151105 @default.
• W2107293885 hasConceptScore W2107293885C2776820930 @default.
• W2107293885 hasConceptScore W2107293885C2776992346 @default.
• W2107293885 hasConceptScore W2107293885C2777451243 @default.
• W2107293885 hasConceptScore W2107293885C2777622882 @default.
• W2107293885 hasConceptScore W2107293885C2778401633 @default.
• W2107293885 hasConceptScore W2107293885C2780771799 @default.
• W2107293885 hasConceptScore W2107293885C2780829032 @default.
• W2107293885 hasConceptScore W2107293885C2780972559 @default.
• W2107293885 hasConceptScore W2107293885C519581460 @default.
• W2107293885 hasConceptScore W2107293885C71924100 @default.

• next