Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107306248> ?p ?o ?g. }
- W2107306248 endingPage "2108" @default.
- W2107306248 startingPage "2099" @default.
- W2107306248 abstract "Aim: We sought to evaluate nanoliposomal irinotecan as an intravenous treatment in an orthotopic brain tumor model. Materials & methods: Nanoliposomal irinotecan was administered intravenously in the intracranial U87MG brain tumor model in mice, and irinotecan and SN-38 levels were analyzed in malignant and normal tissues. Therapy studies were performed in comparison to free irinotecan and control treatments. Results: Tissue analysis demonstrated favorable properties for nanoliposomal irinotecan, including a 10.9-fold increase in tumor AUC for drug compared with free irinotecan and 35-fold selectivity for tumor versus normal tissue exposure. As a therapy for orthotopic brain tumors, nanoliposomal irinotecan showed a mean survival time of 54.2 versus 29.5 days for free irinotecan. A total of 33% of the animals receiving nanoliposomal irinotecan showed no residual tumor by study end compared with no survivors in the other groups. Conclusion: Nanoliposomal irinotecan administered systemically provides significant pharmacologic advantages and may be an efficacious therapy for brain tumors. Original submitted 1 March 2013; Revised submitted 10 October 2013" @default.
- W2107306248 created "2016-06-24" @default.
- W2107306248 creator A5006262715 @default.
- W2107306248 creator A5008160506 @default.
- W2107306248 creator A5008415707 @default.
- W2107306248 creator A5009887167 @default.
- W2107306248 creator A5020903534 @default.
- W2107306248 creator A5028882834 @default.
- W2107306248 creator A5040555359 @default.
- W2107306248 creator A5041524179 @default.
- W2107306248 creator A5046000506 @default.
- W2107306248 creator A5062541015 @default.
- W2107306248 creator A5078449638 @default.
- W2107306248 date "2014-07-01" @default.
- W2107306248 modified "2023-10-17" @default.
- W2107306248 title "Pharmacokinetics, tumor accumulation and antitumor activity of nanoliposomal irinotecan following systemic treatment of intracranial tumors" @default.
- W2107306248 cites W1513897103 @default.
- W2107306248 cites W1532480092 @default.
- W2107306248 cites W1559459501 @default.
- W2107306248 cites W1966174640 @default.
- W2107306248 cites W1977940746 @default.
- W2107306248 cites W1985858988 @default.
- W2107306248 cites W1989975709 @default.
- W2107306248 cites W1990920587 @default.
- W2107306248 cites W1992656294 @default.
- W2107306248 cites W199447113 @default.
- W2107306248 cites W1998733943 @default.
- W2107306248 cites W1999199520 @default.
- W2107306248 cites W2009058800 @default.
- W2107306248 cites W2010084462 @default.
- W2107306248 cites W2013319406 @default.
- W2107306248 cites W2021724108 @default.
- W2107306248 cites W2024808560 @default.
- W2107306248 cites W2027292955 @default.
- W2107306248 cites W2041073833 @default.
- W2107306248 cites W2055402663 @default.
- W2107306248 cites W2061225714 @default.
- W2107306248 cites W2066861571 @default.
- W2107306248 cites W2070607082 @default.
- W2107306248 cites W2071391095 @default.
- W2107306248 cites W2072714492 @default.
- W2107306248 cites W2073447836 @default.
- W2107306248 cites W2074008850 @default.
- W2107306248 cites W2076226743 @default.
- W2107306248 cites W2077559813 @default.
- W2107306248 cites W2078816993 @default.
- W2107306248 cites W2082844918 @default.
- W2107306248 cites W2082997526 @default.
- W2107306248 cites W2087830545 @default.
- W2107306248 cites W2089117567 @default.
- W2107306248 cites W2105603202 @default.
- W2107306248 cites W2116153694 @default.
- W2107306248 cites W2123383613 @default.
- W2107306248 cites W2125541186 @default.
- W2107306248 cites W2128866261 @default.
- W2107306248 cites W2130333865 @default.
- W2107306248 cites W2135062838 @default.
- W2107306248 cites W2141960867 @default.
- W2107306248 cites W2144020449 @default.
- W2107306248 cites W2147182047 @default.
- W2107306248 cites W2148774408 @default.
- W2107306248 cites W2163409320 @default.
- W2107306248 cites W2165824272 @default.
- W2107306248 cites W2168943084 @default.
- W2107306248 cites W2324886883 @default.
- W2107306248 cites W2328209945 @default.
- W2107306248 cites W3011556 @default.
- W2107306248 cites W4255214479 @default.
- W2107306248 doi "https://doi.org/10.2217/nnm.13.201" @default.
- W2107306248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24494810" @default.
- W2107306248 hasPublicationYear "2014" @default.
- W2107306248 type Work @default.
- W2107306248 sameAs 2107306248 @default.
- W2107306248 citedByCount "19" @default.
- W2107306248 countsByYear W21073062482015 @default.
- W2107306248 countsByYear W21073062482016 @default.
- W2107306248 countsByYear W21073062482017 @default.
- W2107306248 countsByYear W21073062482018 @default.
- W2107306248 countsByYear W21073062482019 @default.
- W2107306248 countsByYear W21073062482020 @default.
- W2107306248 countsByYear W21073062482022 @default.
- W2107306248 countsByYear W21073062482023 @default.
- W2107306248 crossrefType "journal-article" @default.
- W2107306248 hasAuthorship W2107306248A5006262715 @default.
- W2107306248 hasAuthorship W2107306248A5008160506 @default.
- W2107306248 hasAuthorship W2107306248A5008415707 @default.
- W2107306248 hasAuthorship W2107306248A5009887167 @default.
- W2107306248 hasAuthorship W2107306248A5020903534 @default.
- W2107306248 hasAuthorship W2107306248A5028882834 @default.
- W2107306248 hasAuthorship W2107306248A5040555359 @default.
- W2107306248 hasAuthorship W2107306248A5041524179 @default.
- W2107306248 hasAuthorship W2107306248A5046000506 @default.
- W2107306248 hasAuthorship W2107306248A5062541015 @default.
- W2107306248 hasAuthorship W2107306248A5078449638 @default.
- W2107306248 hasConcept C112705442 @default.
- W2107306248 hasConcept C121608353 @default.
- W2107306248 hasConcept C126322002 @default.
- W2107306248 hasConcept C142724271 @default.