FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107310088> ?p ?o ?g. }

• W2107310088 endingPage "64" @default.
• W2107310088 startingPage "55" @default.
• W2107310088 abstract "Members of the cytokine receptor family are composed of several noncovalently linked chains with sequence and structure homologies in their extracellular domain. Receptor subfamily members share at least one component: thus the receptors for interleukin (IL) 2 and IL15 have common beta and gamma chains, while those for IL2, 4, 7, and 9 have a common gamma chain. The intracellular pathway followed by IL2 receptors after ligand binding and endocytosis was analyzed by immunofluorescence and confocal microscopy in a human T lymphocytic cell line. Surprisingly, the alpha, beta, and gamma chains had different intracellular localizations after being endocytosed together. The alpha chain was always in transferrin-positive compartments (early/recycling endosomes), both at early and late internalization times, but was never detected in rab7-positive compartments (late endosomes). On the other hand, at late internalization times, the beta and gamma chains were excluded from transferrin-positive organelles and did not colocalize with alpha. Furthermore, beta could be found in rab7-positive vesicles. These differences suggest that the alpha chain recycles to the plasma membrane, while the beta and gamma chains are sorted towards the degradation pathway. The half-lives of these three chains on the cell surface also reflect their different intracellular fates after endocytosis. The beta and gamma chains are very short-lived polypeptides since their half-life on the surface is only approximately 1 h, whereas alpha is a much more stable surface protein. This shows for the first time that components of a multimeric receptor can be sorted separately along the endocytic pathway." @default.
• W2107310088 created "2016-06-24" @default.
• W2107310088 creator A5000893045 @default.
• W2107310088 creator A5032177716 @default.
• W2107310088 creator A5040928609 @default.
• W2107310088 creator A5047377168 @default.
• W2107310088 creator A5077421907 @default.
• W2107310088 creator A5085630600 @default.
• W2107310088 date "1995-04-01" @default.
• W2107310088 modified "2023-10-17" @default.
• W2107310088 title "Endocytosis of interleukin 2 receptors in human T lymphocytes: distinct intracellular localization and fate of the receptor alpha, beta, and gamma chains." @default.
• W2107310088 cites W1487134204 @default.
• W2107310088 cites W1511769880 @default.
• W2107310088 cites W1512843295 @default.
• W2107310088 cites W1549865113 @default.
• W2107310088 cites W1567604499 @default.
• W2107310088 cites W1581234839 @default.
• W2107310088 cites W1587854090 @default.
• W2107310088 cites W1596679547 @default.
• W2107310088 cites W1599169969 @default.
• W2107310088 cites W1599946116 @default.
• W2107310088 cites W1599970058 @default.
• W2107310088 cites W1944263241 @default.
• W2107310088 cites W1969115085 @default.
• W2107310088 cites W1970198954 @default.
• W2107310088 cites W1971500432 @default.
• W2107310088 cites W1972254316 @default.
• W2107310088 cites W1979676829 @default.
• W2107310088 cites W1985633855 @default.
• W2107310088 cites W1988928374 @default.
• W2107310088 cites W1994584656 @default.
• W2107310088 cites W1994613565 @default.
• W2107310088 cites W2000907624 @default.
• W2107310088 cites W2006585409 @default.
• W2107310088 cites W2007324489 @default.
• W2107310088 cites W2009417025 @default.
• W2107310088 cites W2011509425 @default.
• W2107310088 cites W2021820438 @default.
• W2107310088 cites W2025812024 @default.
• W2107310088 cites W2027978484 @default.
• W2107310088 cites W2029275361 @default.
• W2107310088 cites W2030176984 @default.
• W2107310088 cites W2033222990 @default.
• W2107310088 cites W2058542706 @default.
• W2107310088 cites W2065365365 @default.
• W2107310088 cites W2068713241 @default.
• W2107310088 cites W2071112640 @default.
• W2107310088 cites W2072252693 @default.
• W2107310088 cites W2083685529 @default.
• W2107310088 cites W2084228983 @default.
• W2107310088 cites W2095600542 @default.
• W2107310088 cites W2096746841 @default.
• W2107310088 cites W2103952358 @default.
• W2107310088 cites W2120056767 @default.
• W2107310088 cites W2123124320 @default.
• W2107310088 cites W2125010485 @default.
• W2107310088 cites W2125338233 @default.
• W2107310088 cites W2130166519 @default.
• W2107310088 cites W2133811759 @default.
• W2107310088 cites W2137418787 @default.
• W2107310088 cites W2141410410 @default.
• W2107310088 cites W2149112824 @default.
• W2107310088 cites W2158558560 @default.
• W2107310088 cites W2168728815 @default.
• W2107310088 cites W2178812731 @default.
• W2107310088 cites W2179236785 @default.
• W2107310088 cites W2315821233 @default.
• W2107310088 cites W2400728565 @default.
• W2107310088 cites W2405420461 @default.
• W2107310088 cites W2463450696 @default.
• W2107310088 doi "https://doi.org/10.1083/jcb.129.1.55" @default.
• W2107310088 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2120376" @default.
• W2107310088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7698995" @default.
• W2107310088 hasPublicationYear "1995" @default.
• W2107310088 type Work @default.
• W2107310088 sameAs 2107310088 @default.
• W2107310088 citedByCount "190" @default.
• W2107310088 countsByYear W21073100882012 @default.
• W2107310088 countsByYear W21073100882013 @default.
• W2107310088 countsByYear W21073100882014 @default.
• W2107310088 countsByYear W21073100882015 @default.
• W2107310088 countsByYear W21073100882016 @default.
• W2107310088 countsByYear W21073100882017 @default.
• W2107310088 countsByYear W21073100882018 @default.
• W2107310088 countsByYear W21073100882019 @default.
• W2107310088 countsByYear W21073100882020 @default.
• W2107310088 countsByYear W21073100882021 @default.
• W2107310088 countsByYear W21073100882022 @default.
• W2107310088 countsByYear W21073100882023 @default.
• W2107310088 crossrefType "journal-article" @default.
• W2107310088 hasAuthorship W2107310088A5000893045 @default.
• W2107310088 hasAuthorship W2107310088A5032177716 @default.
• W2107310088 hasAuthorship W2107310088A5040928609 @default.
• W2107310088 hasAuthorship W2107310088A5047377168 @default.
• W2107310088 hasAuthorship W2107310088A5077421907 @default.
• W2107310088 hasAuthorship W2107310088A5085630600 @default.
• W2107310088 hasBestOaLocation W21073100881 @default.
• W2107310088 hasConcept C102747710 @default.

• next