Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107316302> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2107316302 endingPage "288" @default.
- W2107316302 startingPage "288" @default.
- W2107316302 abstract "Monoclonal antibodies to human prostate adenocarcinoma membrane antigens were produced by fusion of P3X63/Ag8 mouse myeloma cells with spleen cells from BALB/c mice immunized against the prostate cancer cell line DU145. The hybrids were screened for antibody production using glutaraldehyde-fixed cells in a solid-phase radioimmunoassay. Antibody-binding specificity was also checked by quantitative adsorption, membrane immunofluorescence, and complement-dependent cytotoxicity assays. A hybridoma clone (83.21) was isolated that secreted antibodies which preferentially bound to several prostate and bladder cancer cell lines but did not bind to a variety of other normal and malignant human cell lines. This antibody also reacted with a cytomegalovirus-transformed human embryonic lung cell line but not to normal human embryonic lung cells. Quantitative adsorption studies demonstrated that the 83.21 monoclonal antibody was strongly reactive to membrane preparations from human prostate adenocarcinoma tissue and a liver metastasis of prostate carcinoma. Little or no binding activity was observed against two other prostate carcinomas, bening prostatic hyperplasia, normal prostate, or normal liver. Binding studies indicate that the 83.21 monoclonal antibody does not bind to alpha-fetoprotein, carcinoembryonic antigen, prostatic acid phosphatase, human leukocyte antigen, beta 2-microglobulin, HLA-Dr antigens, fibronectin, or prostate antigen. The data indicate that we have isolated a monoclonal antibody that binds to an antigen(s) expressed by several urogenital carcinoma cell lines as well as human prostate tumor tissue and that the antibody is not directed against well-known human tumor cell markers." @default.
- W2107316302 created "2016-06-24" @default.
- W2107316302 creator A5049575735 @default.
- W2107316302 creator A5051475178 @default.
- W2107316302 creator A5054162807 @default.
- W2107316302 creator A5066238355 @default.
- W2107316302 creator A5087998355 @default.
- W2107316302 creator A5091669057 @default.
- W2107316302 date "1983-01-01" @default.
- W2107316302 modified "2023-09-23" @default.
- W2107316302 title "Monoclonal Antibodies to Human Prostate and Bladder Tumor Associated Antigens" @default.
- W2107316302 cites W112391416 @default.
- W2107316302 cites W1775749144 @default.
- W2107316302 cites W1997194067 @default.
- W2107316302 cites W2007327393 @default.
- W2107316302 cites W2012225661 @default.
- W2107316302 cites W2012769918 @default.
- W2107316302 cites W2030522563 @default.
- W2107316302 cites W2038165289 @default.
- W2107316302 cites W2045138319 @default.
- W2107316302 cites W2047118684 @default.
- W2107316302 cites W2053004397 @default.
- W2107316302 cites W2060491787 @default.
- W2107316302 cites W2075452415 @default.
- W2107316302 cites W2076718572 @default.
- W2107316302 cites W2082791976 @default.
- W2107316302 cites W2083995483 @default.
- W2107316302 cites W2091468986 @default.
- W2107316302 cites W2129125401 @default.
- W2107316302 cites W2339258587 @default.
- W2107316302 cites W2405515343 @default.
- W2107316302 cites W2412708508 @default.
- W2107316302 cites W2413036251 @default.
- W2107316302 cites W2418435788 @default.
- W2107316302 cites W2467047558 @default.
- W2107316302 cites W63256203 @default.
- W2107316302 doi "https://doi.org/10.1007/978-1-4615-9352-2_22" @default.
- W2107316302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7046915" @default.
- W2107316302 hasPublicationYear "1983" @default.
- W2107316302 type Work @default.
- W2107316302 sameAs 2107316302 @default.
- W2107316302 citedByCount "22" @default.
- W2107316302 crossrefType "book-chapter" @default.
- W2107316302 hasAuthorship W2107316302A5049575735 @default.
- W2107316302 hasAuthorship W2107316302A5051475178 @default.
- W2107316302 hasAuthorship W2107316302A5054162807 @default.
- W2107316302 hasAuthorship W2107316302A5066238355 @default.
- W2107316302 hasAuthorship W2107316302A5087998355 @default.
- W2107316302 hasAuthorship W2107316302A5091669057 @default.
- W2107316302 hasConcept C121608353 @default.
- W2107316302 hasConcept C142724271 @default.
- W2107316302 hasConcept C147483822 @default.
- W2107316302 hasConcept C153911025 @default.
- W2107316302 hasConcept C159654299 @default.
- W2107316302 hasConcept C203014093 @default.
- W2107316302 hasConcept C2776235491 @default.
- W2107316302 hasConcept C2776438761 @default.
- W2107316302 hasConcept C2776490512 @default.
- W2107316302 hasConcept C2779723316 @default.
- W2107316302 hasConcept C502942594 @default.
- W2107316302 hasConcept C542903549 @default.
- W2107316302 hasConcept C54355233 @default.
- W2107316302 hasConcept C71924100 @default.
- W2107316302 hasConcept C86803240 @default.
- W2107316302 hasConceptScore W2107316302C121608353 @default.
- W2107316302 hasConceptScore W2107316302C142724271 @default.
- W2107316302 hasConceptScore W2107316302C147483822 @default.
- W2107316302 hasConceptScore W2107316302C153911025 @default.
- W2107316302 hasConceptScore W2107316302C159654299 @default.
- W2107316302 hasConceptScore W2107316302C203014093 @default.
- W2107316302 hasConceptScore W2107316302C2776235491 @default.
- W2107316302 hasConceptScore W2107316302C2776438761 @default.
- W2107316302 hasConceptScore W2107316302C2776490512 @default.
- W2107316302 hasConceptScore W2107316302C2779723316 @default.
- W2107316302 hasConceptScore W2107316302C502942594 @default.
- W2107316302 hasConceptScore W2107316302C542903549 @default.
- W2107316302 hasConceptScore W2107316302C54355233 @default.
- W2107316302 hasConceptScore W2107316302C71924100 @default.
- W2107316302 hasConceptScore W2107316302C86803240 @default.
- W2107316302 hasLocation W21073163021 @default.
- W2107316302 hasLocation W21073163022 @default.
- W2107316302 hasOpenAccess W2107316302 @default.
- W2107316302 hasPrimaryLocation W21073163021 @default.
- W2107316302 hasRelatedWork W1973692620 @default.
- W2107316302 hasRelatedWork W1995949682 @default.
- W2107316302 hasRelatedWork W2001884033 @default.
- W2107316302 hasRelatedWork W2027193501 @default.
- W2107316302 hasRelatedWork W2032030205 @default.
- W2107316302 hasRelatedWork W2037509311 @default.
- W2107316302 hasRelatedWork W2049217275 @default.
- W2107316302 hasRelatedWork W2074545760 @default.
- W2107316302 hasRelatedWork W2094639405 @default.
- W2107316302 hasRelatedWork W2398608068 @default.
- W2107316302 isParatext "false" @default.
- W2107316302 isRetracted "false" @default.
- W2107316302 magId "2107316302" @default.
- W2107316302 workType "book-chapter" @default.