Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107324732> ?p ?o ?g. }
- W2107324732 endingPage "93" @default.
- W2107324732 startingPage "89" @default.
- W2107324732 abstract "This study aims at evaluating the importance of the two-component regulatory system VicRK to virulence of the horse pathogen Streptococcus equi subspecies equi and the potential of a vicK mutant as a live vaccine candidate using mouse infection models. The vicK gene was deleted by gene replacement. The ΔvicK mutant is attenuated in virulence in both subcutaneous and intranasal infections in mice. ΔvicK grows less slowly than the parent strain but retains the ability of S. equi to resist to phagocytosis by polymorphoneuclear leukocytes, suggesting that the vicK deletion causes growth defect. ΔvicK infection protects mice against reinfection with a wild-type S. equi strain. Intranasal ΔvicK infection induces production of anti-SeM mucosal IgA and systemic IgG. These results indicate that VicRK is important to S. equi growth and virulence and suggest that ΔvicK has the potential to be developed as a live S. equi vaccine." @default.
- W2107324732 created "2016-06-24" @default.
- W2107324732 creator A5003712486 @default.
- W2107324732 creator A5021680466 @default.
- W2107324732 creator A5025203398 @default.
- W2107324732 creator A5040344252 @default.
- W2107324732 creator A5041223114 @default.
- W2107324732 date "2008-07-24" @default.
- W2107324732 modified "2023-09-28" @default.
- W2107324732 title "The Two-Component Regulatory System VicRK is Important to Virulence of Streptococcus equi Subspecies equi" @default.
- W2107324732 cites W1507853369 @default.
- W2107324732 cites W1856734764 @default.
- W2107324732 cites W1925986327 @default.
- W2107324732 cites W1993773143 @default.
- W2107324732 cites W2000951555 @default.
- W2107324732 cites W2034024924 @default.
- W2107324732 cites W2047300379 @default.
- W2107324732 cites W2047875207 @default.
- W2107324732 cites W2052629708 @default.
- W2107324732 cites W2093257123 @default.
- W2107324732 cites W2109375247 @default.
- W2107324732 cites W2118291047 @default.
- W2107324732 cites W2119164642 @default.
- W2107324732 cites W2129234138 @default.
- W2107324732 cites W2130079166 @default.
- W2107324732 cites W2135920253 @default.
- W2107324732 cites W2164101095 @default.
- W2107324732 cites W2169589212 @default.
- W2107324732 cites W2171301808 @default.
- W2107324732 cites W2409950209 @default.
- W2107324732 doi "https://doi.org/10.2174/1874285800802010089" @default.
- W2107324732 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2593050" @default.
- W2107324732 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19088917" @default.
- W2107324732 hasPublicationYear "2008" @default.
- W2107324732 type Work @default.
- W2107324732 sameAs 2107324732 @default.
- W2107324732 citedByCount "9" @default.
- W2107324732 countsByYear W21073247322013 @default.
- W2107324732 countsByYear W21073247322014 @default.
- W2107324732 countsByYear W21073247322018 @default.
- W2107324732 countsByYear W21073247322019 @default.
- W2107324732 countsByYear W21073247322021 @default.
- W2107324732 countsByYear W21073247322023 @default.
- W2107324732 crossrefType "journal-article" @default.
- W2107324732 hasAuthorship W2107324732A5003712486 @default.
- W2107324732 hasAuthorship W2107324732A5021680466 @default.
- W2107324732 hasAuthorship W2107324732A5025203398 @default.
- W2107324732 hasAuthorship W2107324732A5040344252 @default.
- W2107324732 hasAuthorship W2107324732A5041223114 @default.
- W2107324732 hasBestOaLocation W21073247321 @default.
- W2107324732 hasConcept C104317684 @default.
- W2107324732 hasConcept C105702510 @default.
- W2107324732 hasConcept C143065580 @default.
- W2107324732 hasConcept C159047783 @default.
- W2107324732 hasConcept C160448771 @default.
- W2107324732 hasConcept C2776460866 @default.
- W2107324732 hasConcept C2778022156 @default.
- W2107324732 hasConcept C2908622527 @default.
- W2107324732 hasConcept C523546767 @default.
- W2107324732 hasConcept C54355233 @default.
- W2107324732 hasConcept C54602769 @default.
- W2107324732 hasConcept C60987743 @default.
- W2107324732 hasConcept C86803240 @default.
- W2107324732 hasConcept C89423630 @default.
- W2107324732 hasConceptScore W2107324732C104317684 @default.
- W2107324732 hasConceptScore W2107324732C105702510 @default.
- W2107324732 hasConceptScore W2107324732C143065580 @default.
- W2107324732 hasConceptScore W2107324732C159047783 @default.
- W2107324732 hasConceptScore W2107324732C160448771 @default.
- W2107324732 hasConceptScore W2107324732C2776460866 @default.
- W2107324732 hasConceptScore W2107324732C2778022156 @default.
- W2107324732 hasConceptScore W2107324732C2908622527 @default.
- W2107324732 hasConceptScore W2107324732C523546767 @default.
- W2107324732 hasConceptScore W2107324732C54355233 @default.
- W2107324732 hasConceptScore W2107324732C54602769 @default.
- W2107324732 hasConceptScore W2107324732C60987743 @default.
- W2107324732 hasConceptScore W2107324732C86803240 @default.
- W2107324732 hasConceptScore W2107324732C89423630 @default.
- W2107324732 hasIssue "1" @default.
- W2107324732 hasLocation W21073247321 @default.
- W2107324732 hasLocation W21073247322 @default.
- W2107324732 hasLocation W21073247323 @default.
- W2107324732 hasLocation W21073247324 @default.
- W2107324732 hasOpenAccess W2107324732 @default.
- W2107324732 hasPrimaryLocation W21073247321 @default.
- W2107324732 hasRelatedWork W1948580609 @default.
- W2107324732 hasRelatedWork W2025890991 @default.
- W2107324732 hasRelatedWork W2032149607 @default.
- W2107324732 hasRelatedWork W2065214355 @default.
- W2107324732 hasRelatedWork W2095425854 @default.
- W2107324732 hasRelatedWork W2097046100 @default.
- W2107324732 hasRelatedWork W2102093956 @default.
- W2107324732 hasRelatedWork W2107324732 @default.
- W2107324732 hasRelatedWork W2131785145 @default.
- W2107324732 hasRelatedWork W2411197773 @default.
- W2107324732 hasVolume "2" @default.
- W2107324732 isParatext "false" @default.
- W2107324732 isRetracted "false" @default.