FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107328758> ?p ?o ?g. }

• W2107328758 endingPage "1023" @default.
• W2107328758 startingPage "1015" @default.
• W2107328758 abstract "Objective— Cardiovascular effects of angiotensin II are primarily mediated via the angiotensin II type 1 receptor (AT1R). Krüppel-like factor 4 (KLF4), a transcription factor that binds to the transforming growth factor (TGF)-β control element (TCE), regulates a variety of receptor expression in vascular smooth muscle cells. In the present study, we investigated the mechanisms of TGF-β-mediated KLF4 regulation of AT1R expression. Methods and Results— Coimmunoprecipitation, chromatin immunoprecipitation, and luciferase assays were performed, with the results suggesting that Sp1 forms a complex with KLF4 bound to the TCE of the AT1R promoter and cooperatively activates AT1R transcription in vascular smooth muscle cells under basal conditions. On activation of TGF-β1 signaling, Sp1 is dissociated from the KLF4-Sp1 complex through PKC-δ-mediated KLF4 phosphorylation at Thr401, downregulating AT1R expression. Simultaneously, TGF-β1 facilitates KLF4-PPAR–γ complex formation and its binding to the TCE of the AT1R promoter through Smad-mediated KLF4 phosphorylation at Ser470, subsequently leading to inhibition of AT1R transcription. Conclusion— KLF4 functions as a protein platform that is able to bind to the TCE of the AT1R promoter. On activation of TGF-β signaling, KLF4 mediates Sp1 dissociation from, and PPAR-γ association with, the AT1R promoter, leading to downregulation of AT1R expression in VSMCs." @default.
• W2107328758 created "2016-06-24" @default.
• W2107328758 creator A5024445733 @default.
• W2107328758 creator A5038042180 @default.
• W2107328758 creator A5038911681 @default.
• W2107328758 creator A5040062610 @default.
• W2107328758 creator A5046639112 @default.
• W2107328758 date "2012-04-01" @default.
• W2107328758 modified "2023-09-26" @default.
• W2107328758 title "TGF-β1 Downregulates AT1 Receptor Expression via PKC-δ-Mediated Sp1 Dissociation From KLF4 and Smad-Mediated PPAR-γ Association With KLF4" @default.
• W2107328758 cites W1971365179 @default.
• W2107328758 cites W1983110775 @default.
• W2107328758 cites W2001025517 @default.
• W2107328758 cites W2020208959 @default.
• W2107328758 cites W2026102591 @default.
• W2107328758 cites W2033159340 @default.
• W2107328758 cites W2048635895 @default.
• W2107328758 cites W2051727048 @default.
• W2107328758 cites W2054229883 @default.
• W2107328758 cites W2055337546 @default.
• W2107328758 cites W2091094453 @default.
• W2107328758 cites W2091917316 @default.
• W2107328758 cites W2092322150 @default.
• W2107328758 cites W2094092110 @default.
• W2107328758 cites W2108193919 @default.
• W2107328758 cites W2117526135 @default.
• W2107328758 cites W2117854326 @default.
• W2107328758 cites W2121631191 @default.
• W2107328758 cites W2123404136 @default.
• W2107328758 cites W2124172600 @default.
• W2107328758 cites W2145510596 @default.
• W2107328758 cites W2147074436 @default.
• W2107328758 cites W2150566395 @default.
• W2107328758 cites W2171796334 @default.
• W2107328758 doi "https://doi.org/10.1161/atvbaha.111.244962" @default.
• W2107328758 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22282354" @default.
• W2107328758 hasPublicationYear "2012" @default.
• W2107328758 type Work @default.
• W2107328758 sameAs 2107328758 @default.
• W2107328758 citedByCount "43" @default.
• W2107328758 countsByYear W21073287582012 @default.
• W2107328758 countsByYear W21073287582013 @default.
• W2107328758 countsByYear W21073287582014 @default.
• W2107328758 countsByYear W21073287582015 @default.
• W2107328758 countsByYear W21073287582016 @default.
• W2107328758 countsByYear W21073287582017 @default.
• W2107328758 countsByYear W21073287582018 @default.
• W2107328758 countsByYear W21073287582019 @default.
• W2107328758 countsByYear W21073287582020 @default.
• W2107328758 countsByYear W21073287582021 @default.
• W2107328758 countsByYear W21073287582022 @default.
• W2107328758 countsByYear W21073287582023 @default.
• W2107328758 crossrefType "journal-article" @default.
• W2107328758 hasAuthorship W2107328758A5024445733 @default.
• W2107328758 hasAuthorship W2107328758A5038042180 @default.
• W2107328758 hasAuthorship W2107328758A5038911681 @default.
• W2107328758 hasAuthorship W2107328758A5040062610 @default.
• W2107328758 hasAuthorship W2107328758A5046639112 @default.
• W2107328758 hasBestOaLocation W21073287581 @default.
• W2107328758 hasConcept C101762097 @default.
• W2107328758 hasConcept C104317684 @default.
• W2107328758 hasConcept C11960822 @default.
• W2107328758 hasConcept C123915805 @default.
• W2107328758 hasConcept C127561419 @default.
• W2107328758 hasConcept C134320426 @default.
• W2107328758 hasConcept C150194340 @default.
• W2107328758 hasConcept C153911025 @default.
• W2107328758 hasConcept C170493617 @default.
• W2107328758 hasConcept C185592680 @default.
• W2107328758 hasConcept C2777933648 @default.
• W2107328758 hasConcept C2778265714 @default.
• W2107328758 hasConcept C2781080636 @default.
• W2107328758 hasConcept C2908929049 @default.
• W2107328758 hasConcept C502942594 @default.
• W2107328758 hasConcept C55493867 @default.
• W2107328758 hasConcept C57467964 @default.
• W2107328758 hasConcept C62478195 @default.
• W2107328758 hasConcept C86339819 @default.
• W2107328758 hasConcept C86803240 @default.
• W2107328758 hasConcept C95444343 @default.
• W2107328758 hasConceptScore W2107328758C101762097 @default.
• W2107328758 hasConceptScore W2107328758C104317684 @default.
• W2107328758 hasConceptScore W2107328758C11960822 @default.
• W2107328758 hasConceptScore W2107328758C123915805 @default.
• W2107328758 hasConceptScore W2107328758C127561419 @default.
• W2107328758 hasConceptScore W2107328758C134320426 @default.
• W2107328758 hasConceptScore W2107328758C150194340 @default.
• W2107328758 hasConceptScore W2107328758C153911025 @default.
• W2107328758 hasConceptScore W2107328758C170493617 @default.
• W2107328758 hasConceptScore W2107328758C185592680 @default.
• W2107328758 hasConceptScore W2107328758C2777933648 @default.
• W2107328758 hasConceptScore W2107328758C2778265714 @default.
• W2107328758 hasConceptScore W2107328758C2781080636 @default.
• W2107328758 hasConceptScore W2107328758C2908929049 @default.
• W2107328758 hasConceptScore W2107328758C502942594 @default.
• W2107328758 hasConceptScore W2107328758C55493867 @default.
• W2107328758 hasConceptScore W2107328758C57467964 @default.
• W2107328758 hasConceptScore W2107328758C62478195 @default.

• next