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• W2107332755 abstract "In this special issue of Free Radical Research, we have organized 15 articles from invited speakers from the “ Biennial Meeting of the Society for Free Radical ResearchAsia ” held at Chang Gung University of Taiwan between October16 – 19, 2013. The theme of this meeting was “ Oxidative stress and mitochondrial alterations in ageing and disease ” . Seven articles in this issue are related to mitochondrial alterations associated with oxidative stress. The rest address oxidative stress and non-mitochondrial issues. The fi rst two articles in this special issue arise from plenary lectures presented at the meeting by Professor Michael Davies and Professor Shinya Toyokuni, respectively. The review article written by Davies and his associates is entitled “ Oxidation and modifi cation of extracellular matrix and its role in disease ” . The nature of the extracellular matrix and the oxidative mechanisms that can cause damage to extracellular matrix as well as evidence for the existence of matrix modifi cations in disease are nicely reviewed [1]. This article is extremely helpful for readers to understand how oxidative damage to extracellular matrix can play an important role in certain human pathologies such as cardiovascular disease. The research article written by Toyokuni and his associates is entitled “ Histological detection of catalytic ferrous iron with the selective turn-on fl uorescent-probe RhoNox-1 in a Fenton reaction-based rat renal carcinogenesis model ” . A novel turn-on fl uorescent probe, which can be specifi cally activated by labile ferrous iron, is introduced. This probe yields an intense red fl uorescent color upon interaction with Fe(II) but not with Fe(II)-nitrilotriacetate, Fe(III) nor Fe(III)-nitrilotriacetate [2]. Since iron overload is associated with a wide variety of human diseases such as atherosclerosis and carcinogenesis, this probe would be exceptionally useful to localize catalytic Fe(II) in tissues, particularly in aging tissues. In addition, there are six exciting articles dealing with oxidative stress and non-mitochondrial – related matters. Two articles relate to S-nitrosylation, one written by M.V. Clement ’ s group and the other by C. Chen ’ s group. In addition to their fi ndings related to S-nitrosylation, these two articles together add support to the current concept that high concentration of oxidants is cytotoxic whereas low" @default.
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• W2107332755 date "2014-08-12" @default.
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• W2107332755 title "Special issue on “Oxidative stress and mitochondrial alterations in aging and disease”" @default.
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• W2107332755 doi "https://doi.org/10.3109/10715762.2014.948536" @default.
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