FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107335337> ?p ?o ?g. }

• W2107335337 endingPage "1628" @default.
• W2107335337 startingPage "1622" @default.
• W2107335337 abstract "A series of acyloxyalkyl esters of ketoprofen and naproxen were synthesized and investigated as topical prodrugs with the aim of improving the dermal delivery of the drugs. In addition, some hydroxyalkyl esters of ketoprofen and naproxen were synthesized as possible intermediates of acyloxyalkyl prodrugs. All of the prodrugs were more lipophilic than their parent molecules, as evaluated by drug partitioning between 1-octanol and phosphate buffer at pH 7.4 (log Papp). However, their solubilities in aqueous solutions decreased markedly compared with the parent molecules. The prodrugs were stable toward chemical hydrolysis in aqueous solutions (pH 7.4), but were hydrolyzed to the parent drug both in 80% human serum and in human skin homogenate, with half-lives ranging from 4 to 137 min and from 13 to 403 min, respectively. The abilities of the selected naproxen acyloxyalkyl prodrugs to deliver naproxen through excised human skin were evaluated. Generally, the prodrugs showed similar dermal delivery as the parent drug through cadaver skin. In the present series of lipophilic prodrugs of naproxen, the prodrug with the highest aqueous solubility was the most effective prodrug to deliver naproxen through the skin." @default.
• W2107335337 created "2016-06-24" @default.
• W2107335337 creator A5044379426 @default.
• W2107335337 creator A5048378169 @default.
• W2107335337 creator A5051447344 @default.
• W2107335337 creator A5060640651 @default.
• W2107335337 creator A5079794909 @default.
• W2107335337 creator A5090323507 @default.
• W2107335337 date "1998-12-01" @default.
• W2107335337 modified "2023-10-18" @default.
• W2107335337 title "In vitro evaluation of acyloxyalkyl esters as dermal prodrugs of ketoprofen and naproxen" @default.
• W2107335337 cites W1966498188 @default.
• W2107335337 cites W1974437354 @default.
• W2107335337 cites W1979372655 @default.
• W2107335337 cites W1982733935 @default.
• W2107335337 cites W1985691179 @default.
• W2107335337 cites W2034344830 @default.
• W2107335337 cites W2037411045 @default.
• W2107335337 cites W2038700530 @default.
• W2107335337 cites W2043325313 @default.
• W2107335337 cites W2043824503 @default.
• W2107335337 cites W2043974098 @default.
• W2107335337 cites W2049908664 @default.
• W2107335337 cites W2054403196 @default.
• W2107335337 cites W2059638755 @default.
• W2107335337 cites W2064805272 @default.
• W2107335337 cites W2071192175 @default.
• W2107335337 cites W2080514897 @default.
• W2107335337 cites W2127400692 @default.
• W2107335337 cites W2141331305 @default.
• W2107335337 cites W2159192437 @default.
• W2107335337 cites W2164841350 @default.
• W2107335337 cites W2183744104 @default.
• W2107335337 cites W2318559650 @default.
• W2107335337 cites W2461979478 @default.
• W2107335337 cites W293452553 @default.
• W2107335337 cites W4248561339 @default.
• W2107335337 doi "https://doi.org/10.1021/js970465w" @default.
• W2107335337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10189277" @default.
• W2107335337 hasPublicationYear "1998" @default.
• W2107335337 type Work @default.
• W2107335337 sameAs 2107335337 @default.
• W2107335337 citedByCount "40" @default.
• W2107335337 countsByYear W21073353372013 @default.
• W2107335337 countsByYear W21073353372014 @default.
• W2107335337 countsByYear W21073353372016 @default.
• W2107335337 countsByYear W21073353372019 @default.
• W2107335337 countsByYear W21073353372022 @default.
• W2107335337 crossrefType "journal-article" @default.
• W2107335337 hasAuthorship W2107335337A5044379426 @default.
• W2107335337 hasAuthorship W2107335337A5048378169 @default.
• W2107335337 hasAuthorship W2107335337A5051447344 @default.
• W2107335337 hasAuthorship W2107335337A5060640651 @default.
• W2107335337 hasAuthorship W2107335337A5079794909 @default.
• W2107335337 hasAuthorship W2107335337A5090323507 @default.
• W2107335337 hasConcept C108215921 @default.
• W2107335337 hasConcept C142724271 @default.
• W2107335337 hasConcept C155574463 @default.
• W2107335337 hasConcept C178790620 @default.
• W2107335337 hasConcept C184651966 @default.
• W2107335337 hasConcept C185592680 @default.
• W2107335337 hasConcept C204787440 @default.
• W2107335337 hasConcept C2777459323 @default.
• W2107335337 hasConcept C2778115740 @default.
• W2107335337 hasConcept C2780035454 @default.
• W2107335337 hasConcept C2780744026 @default.
• W2107335337 hasConcept C43617362 @default.
• W2107335337 hasConcept C54355233 @default.
• W2107335337 hasConcept C55493867 @default.
• W2107335337 hasConcept C71924100 @default.
• W2107335337 hasConcept C86803240 @default.
• W2107335337 hasConcept C94412978 @default.
• W2107335337 hasConcept C98274493 @default.
• W2107335337 hasConceptScore W2107335337C108215921 @default.
• W2107335337 hasConceptScore W2107335337C142724271 @default.
• W2107335337 hasConceptScore W2107335337C155574463 @default.
• W2107335337 hasConceptScore W2107335337C178790620 @default.
• W2107335337 hasConceptScore W2107335337C184651966 @default.
• W2107335337 hasConceptScore W2107335337C185592680 @default.
• W2107335337 hasConceptScore W2107335337C204787440 @default.
• W2107335337 hasConceptScore W2107335337C2777459323 @default.
• W2107335337 hasConceptScore W2107335337C2778115740 @default.
• W2107335337 hasConceptScore W2107335337C2780035454 @default.
• W2107335337 hasConceptScore W2107335337C2780744026 @default.
• W2107335337 hasConceptScore W2107335337C43617362 @default.
• W2107335337 hasConceptScore W2107335337C54355233 @default.
• W2107335337 hasConceptScore W2107335337C55493867 @default.
• W2107335337 hasConceptScore W2107335337C71924100 @default.
• W2107335337 hasConceptScore W2107335337C86803240 @default.
• W2107335337 hasConceptScore W2107335337C94412978 @default.
• W2107335337 hasConceptScore W2107335337C98274493 @default.
• W2107335337 hasIssue "12" @default.
• W2107335337 hasLocation W21073353371 @default.
• W2107335337 hasLocation W21073353372 @default.
• W2107335337 hasOpenAccess W2107335337 @default.
• W2107335337 hasPrimaryLocation W21073353371 @default.
• W2107335337 hasRelatedWork W1968937971 @default.
• W2107335337 hasRelatedWork W2056796982 @default.

• next