FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107337535> ?p ?o ?g. }

• W2107337535 endingPage "181" @default.
• W2107337535 startingPage "171" @default.
• W2107337535 abstract "Clinical and preclinical data suggest that unrestrained secretion of corticoctropin-releasing hormone (CRH) in the CNS produces several signs and symptoms of depression and anxiety disorders through continuous activation of CRH1 receptors. This led to the development of drugs that selectively antagonize CRH1 receptors suppressing anxiety-like behavior in rats and also in monkey models of anxiety. These findings led to a clinical development program exploring the antidepressive potential of R121919, a water-soluble pyrrolopyrimidine that binds with high affinity to human CRH1 receptors and is well absorbed in humans. This compound was administered to 24 patients with a major depressive episode primarily in order to investigate whether its endocrine mode of action compromises the stress-hormone system or whether other safety and tolerability issues exist. The patients were enrolled in two dose-escalation panels: one group (n=10) where the dose range increased from 5–40 mg and another group (n=10) where the dose escalated from 40 to 80 mg within 30 days each. Four patients dropped out because of withdrawal of consent to participate (three cases) or worsening of depressive symptomatoloy in one case. We found that R121919 was safe and well tolerated by the patients during the observation period. Moreover, the data suggested that CRH1-receptor blockade does not impair the corticotropin and cortisol secretory activity either at baseline or following an exogenous CRH challenge. We also observed significant reductions in depression and anxiety scores using both, patient and clinician ratings. These findings, along with the observed worsening of affective symptomatology after drug discontinuation, suggests that the pharmacological principle of CRH1-receptor antagonism has considerable therapeutic potential in the treatment and the prevention of diseases where exaggerated central CRH activity is present at baseline or following stress exposure." @default.
• W2107337535 created "2016-06-24" @default.
• W2107337535 creator A5019778741 @default.
• W2107337535 creator A5020663736 @default.
• W2107337535 creator A5037468595 @default.
• W2107337535 creator A5044329719 @default.
• W2107337535 creator A5049541960 @default.
• W2107337535 creator A5074716536 @default.
• W2107337535 creator A5076046462 @default.
• W2107337535 date "2000-05-01" @default.
• W2107337535 modified "2023-10-13" @default.
• W2107337535 title "Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated" @default.
• W2107337535 cites W1572525448 @default.
• W2107337535 cites W1695838946 @default.
• W2107337535 cites W1773010387 @default.
• W2107337535 cites W1965701483 @default.
• W2107337535 cites W1967569415 @default.
• W2107337535 cites W1968985482 @default.
• W2107337535 cites W1969047053 @default.
• W2107337535 cites W1973783162 @default.
• W2107337535 cites W1973994559 @default.
• W2107337535 cites W1974253960 @default.
• W2107337535 cites W1981304815 @default.
• W2107337535 cites W1986216587 @default.
• W2107337535 cites W1986576876 @default.
• W2107337535 cites W1987852700 @default.
• W2107337535 cites W1988230174 @default.
• W2107337535 cites W2013384289 @default.
• W2107337535 cites W2032947885 @default.
• W2107337535 cites W2038716310 @default.
• W2107337535 cites W2047620892 @default.
• W2107337535 cites W2059692874 @default.
• W2107337535 cites W2062636872 @default.
• W2107337535 cites W2068818952 @default.
• W2107337535 cites W2071070948 @default.
• W2107337535 cites W2074442917 @default.
• W2107337535 cites W2083555314 @default.
• W2107337535 cites W2087334617 @default.
• W2107337535 cites W2091456614 @default.
• W2107337535 cites W2095036452 @default.
• W2107337535 cites W2107852322 @default.
• W2107337535 cites W2119951209 @default.
• W2107337535 cites W2156994072 @default.
• W2107337535 cites W2171846995 @default.
• W2107337535 cites W2171952745 @default.
• W2107337535 cites W2402656846 @default.
• W2107337535 cites W4239526510 @default.
• W2107337535 cites W4239535205 @default.
• W2107337535 cites W4376848280 @default.
• W2107337535 doi "https://doi.org/10.1016/s0022-3956(00)00016-9" @default.
• W2107337535 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10867111" @default.
• W2107337535 hasPublicationYear "2000" @default.
• W2107337535 type Work @default.
• W2107337535 sameAs 2107337535 @default.
• W2107337535 citedByCount "657" @default.
• W2107337535 countsByYear W21073375352012 @default.
• W2107337535 countsByYear W21073375352013 @default.
• W2107337535 countsByYear W21073375352014 @default.
• W2107337535 countsByYear W21073375352015 @default.
• W2107337535 countsByYear W21073375352016 @default.
• W2107337535 countsByYear W21073375352017 @default.
• W2107337535 countsByYear W21073375352018 @default.
• W2107337535 countsByYear W21073375352019 @default.
• W2107337535 countsByYear W21073375352020 @default.
• W2107337535 countsByYear W21073375352021 @default.
• W2107337535 countsByYear W21073375352022 @default.
• W2107337535 countsByYear W21073375352023 @default.
• W2107337535 crossrefType "journal-article" @default.
• W2107337535 hasAuthorship W2107337535A5019778741 @default.
• W2107337535 hasAuthorship W2107337535A5020663736 @default.
• W2107337535 hasAuthorship W2107337535A5037468595 @default.
• W2107337535 hasAuthorship W2107337535A5044329719 @default.
• W2107337535 hasAuthorship W2107337535A5049541960 @default.
• W2107337535 hasAuthorship W2107337535A5074716536 @default.
• W2107337535 hasAuthorship W2107337535A5076046462 @default.
• W2107337535 hasConcept C118552586 @default.
• W2107337535 hasConcept C126322002 @default.
• W2107337535 hasConcept C134018914 @default.
• W2107337535 hasConcept C139719470 @default.
• W2107337535 hasConcept C15744967 @default.
• W2107337535 hasConcept C162324750 @default.
• W2107337535 hasConcept C170493617 @default.
• W2107337535 hasConcept C197934379 @default.
• W2107337535 hasConcept C2776867660 @default.
• W2107337535 hasConcept C2776885963 @default.
• W2107337535 hasConcept C2778375690 @default.
• W2107337535 hasConcept C2778458438 @default.
• W2107337535 hasConcept C2778468042 @default.
• W2107337535 hasConcept C2778709874 @default.
• W2107337535 hasConcept C2781210005 @default.
• W2107337535 hasConcept C46699223 @default.
• W2107337535 hasConcept C558461103 @default.
• W2107337535 hasConcept C71315377 @default.
• W2107337535 hasConcept C71924100 @default.
• W2107337535 hasConceptScore W2107337535C118552586 @default.
• W2107337535 hasConceptScore W2107337535C126322002 @default.
• W2107337535 hasConceptScore W2107337535C134018914 @default.
• W2107337535 hasConceptScore W2107337535C139719470 @default.

• next