FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107366988> ?p ?o ?g. }

• W2107366988 endingPage "369" @default.
• W2107366988 startingPage "363" @default.
• W2107366988 abstract "Summary Background: Neuropathic pain is associated with disease or injury to the peripheral or central nervous system, which is considered particularly difficult to treat due to its diverse etiology and underlying physiopathological mechanisms. Recent experimental and clinical data support the potential of pharmacotherapy using a combination of drugs for neuropathic pain. Methods: In order to assess a possible synergistic anti-hyperalgesic interaction, the anti-hyperalgesic effects of morphine and gabapentin, single-dose administered either separately or in combination, were determined using the von Frey test in a rat model of neuropathic pain (Bennett model). Results: Time course analysis showed that morphine (3.2 mg/kg SC) and gabapentin (17.8 mg/kg SC) individually reached their maximum effect at 60 min after treatment, producing an antihyperalgesic effect of 51.7 ± 10.5 % and 55.0 ± 11.7 %, respectively, whereas the combination morphine + gabapentin (3.2 + 17.8 mg/kg SC) produced an almost total anti-hyperalgesic effect at 30 min (96.7 ± 2.1 %) and at 60 min showed 100 % anti-hyperalgesia. This anti-hyperalgesic effect remained during 180 min of observation. Analysis of global effects as area under the curve of time course showed that the nature of the antihyperalgesic interaction of the analyzed dose had an additive effect. There was no significant difference observed in the theoretical sum of anti-hyperalgesic effect produced by each drug alone (225.4 ± 29.1 area units, au) compared with the corresponding effects produced by the combination of drugs (263.33 ± 3.3 au). Conclusions: These findings are useful in determining the type of interaction that these drugs produce using this combination ratio in neuropathic pain." @default.
• W2107366988 created "2016-06-24" @default.
• W2107366988 creator A5002826540 @default.
• W2107366988 creator A5028305111 @default.
• W2107366988 creator A5065965614 @default.
• W2107366988 creator A5066740226 @default.
• W2107366988 creator A5060950931 @default.
• W2107366988 date "2007-09-01" @default.
• W2107366988 modified "2023-10-18" @default.
• W2107366988 title "Efecto antihiperalgésico de una combinación de morfina y gabapentina en dolor neuropático inducido por constricción crónica en rata" @default.
• W2107366988 cites W1536502087 @default.
• W2107366988 cites W1593450664 @default.
• W2107366988 cites W1963844198 @default.
• W2107366988 cites W1975101207 @default.
• W2107366988 cites W1978283158 @default.
• W2107366988 cites W1978921669 @default.
• W2107366988 cites W1982133049 @default.
• W2107366988 cites W1984832858 @default.
• W2107366988 cites W1986018857 @default.
• W2107366988 cites W1994903752 @default.
• W2107366988 cites W1995465610 @default.
• W2107366988 cites W2007122791 @default.
• W2107366988 cites W2009965676 @default.
• W2107366988 cites W2010845171 @default.
• W2107366988 cites W2012520893 @default.
• W2107366988 cites W2016769860 @default.
• W2107366988 cites W2020512823 @default.
• W2107366988 cites W2021575364 @default.
• W2107366988 cites W2021817294 @default.
• W2107366988 cites W2033817488 @default.
• W2107366988 cites W2042086981 @default.
• W2107366988 cites W2049141458 @default.
• W2107366988 cites W2052574100 @default.
• W2107366988 cites W2054368970 @default.
• W2107366988 cites W2058020736 @default.
• W2107366988 cites W2070648381 @default.
• W2107366988 cites W2075813287 @default.
• W2107366988 cites W2084190290 @default.
• W2107366988 cites W2084443414 @default.
• W2107366988 cites W2087454739 @default.
• W2107366988 cites W2097370011 @default.
• W2107366988 cites W2099854799 @default.
• W2107366988 cites W2103289578 @default.
• W2107366988 cites W2103909695 @default.
• W2107366988 cites W2112502671 @default.
• W2107366988 cites W2114903378 @default.
• W2107366988 cites W2121270079 @default.
• W2107366988 cites W2131183945 @default.
• W2107366988 cites W2143221646 @default.
• W2107366988 cites W2143538143 @default.
• W2107366988 cites W2152953447 @default.
• W2107366988 cites W2165085297 @default.
• W2107366988 cites W2167024809 @default.
• W2107366988 cites W2170284609 @default.
• W2107366988 cites W2254203571 @default.
• W2107366988 cites W3192365919 @default.
• W2107366988 cites W2188759965 @default.
• W2107366988 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18158883" @default.
• W2107366988 hasPublicationYear "2007" @default.
• W2107366988 type Work @default.
• W2107366988 sameAs 2107366988 @default.
• W2107366988 citedByCount "2" @default.
• W2107366988 countsByYear W21073669882014 @default.
• W2107366988 countsByYear W21073669882016 @default.
• W2107366988 crossrefType "journal-article" @default.
• W2107366988 hasAuthorship W2107366988A5002826540 @default.
• W2107366988 hasAuthorship W2107366988A5028305111 @default.
• W2107366988 hasAuthorship W2107366988A5060950931 @default.
• W2107366988 hasAuthorship W2107366988A5065965614 @default.
• W2107366988 hasAuthorship W2107366988A5066740226 @default.
• W2107366988 hasConcept C126322002 @default.
• W2107366988 hasConcept C142724271 @default.
• W2107366988 hasConcept C15490471 @default.
• W2107366988 hasConcept C170493617 @default.
• W2107366988 hasConcept C204787440 @default.
• W2107366988 hasConcept C2776608144 @default.
• W2107366988 hasConcept C2777107010 @default.
• W2107366988 hasConcept C2777389121 @default.
• W2107366988 hasConcept C2779245659 @default.
• W2107366988 hasConcept C42219234 @default.
• W2107366988 hasConcept C71924100 @default.
• W2107366988 hasConcept C98274493 @default.
• W2107366988 hasConceptScore W2107366988C126322002 @default.
• W2107366988 hasConceptScore W2107366988C142724271 @default.
• W2107366988 hasConceptScore W2107366988C15490471 @default.
• W2107366988 hasConceptScore W2107366988C170493617 @default.
• W2107366988 hasConceptScore W2107366988C204787440 @default.
• W2107366988 hasConceptScore W2107366988C2776608144 @default.
• W2107366988 hasConceptScore W2107366988C2777107010 @default.
• W2107366988 hasConceptScore W2107366988C2777389121 @default.
• W2107366988 hasConceptScore W2107366988C2779245659 @default.
• W2107366988 hasConceptScore W2107366988C42219234 @default.
• W2107366988 hasConceptScore W2107366988C71924100 @default.
• W2107366988 hasConceptScore W2107366988C98274493 @default.
• W2107366988 hasIssue "5" @default.
• W2107366988 hasLocation W21073669881 @default.
• W2107366988 hasLocation W21073669882 @default.
• W2107366988 hasOpenAccess W2107366988 @default.

• next