Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107368518> ?p ?o ?g. }
- W2107368518 endingPage "1121" @default.
- W2107368518 startingPage "1112" @default.
- W2107368518 abstract "E-peptide of the pro-insulin-like growth factor (pro-IGF)-I is produced by proteolytic cleavage of the pro-hormone in post-translational processing. Introduction of a transgene encoding a secreted form of rtEa4- or hEb-peptide into newly fertilized zebrafish (Danio rerio) eggs by electroporation or microinjection resulted in embryos with abnormal cardiovascular features and reduced red blood cells and vasculature. Two different phenocopies of heart developmental defects were observed: (i) Group I embryos exhibited heart development arrested at the heart muscle stage and (ii) group II embryos exhibited heart development arrested at the heart tube stage. Both groups of embryos also exhibited reduction of red blood cells and vasculature. The mRNA levels of genes essential for heart development (GATA 5 and NKX2.5), hematopoiesis (GATA 1 and GATA 2), and vasculogenesis (VEGF) in normal and defective embryos were determined by quantitative real-time RT-PCR at 36 hr post-fertilization (hpf). Significant reduction of GATA 5, NKX2.5, GATA 1, GATA 2, and VEGF mRNA levels was observed in both groups of defective embryos. These results suggest that overexpression of rtEa4 or hEb transgene in zebrafish embryos disrupts heart development, hematopoiesis, and vasculogenesis by reducing the levels of GATA 5, NKX2.5, GATA 1, GATA 2, and VEGF mRNA." @default.
- W2107368518 created "2016-06-24" @default.
- W2107368518 creator A5000769262 @default.
- W2107368518 creator A5018078683 @default.
- W2107368518 creator A5076564378 @default.
- W2107368518 date "2006-06-29" @default.
- W2107368518 modified "2023-10-14" @default.
- W2107368518 title "Trout Ea4- or human Eb-peptide of pro-IGF-I disrupts heart, red blood cell, and vasculature development in zebrafish embryos" @default.
- W2107368518 cites W1545380907 @default.
- W2107368518 cites W1577509897 @default.
- W2107368518 cites W1890916383 @default.
- W2107368518 cites W1957871175 @default.
- W2107368518 cites W1966443300 @default.
- W2107368518 cites W1973854977 @default.
- W2107368518 cites W1981460612 @default.
- W2107368518 cites W1984338606 @default.
- W2107368518 cites W1984607318 @default.
- W2107368518 cites W1990827407 @default.
- W2107368518 cites W1994625982 @default.
- W2107368518 cites W2000647402 @default.
- W2107368518 cites W2003598961 @default.
- W2107368518 cites W2003720824 @default.
- W2107368518 cites W2010332455 @default.
- W2107368518 cites W2016570884 @default.
- W2107368518 cites W2021516648 @default.
- W2107368518 cites W2025817195 @default.
- W2107368518 cites W2028261068 @default.
- W2107368518 cites W2042427553 @default.
- W2107368518 cites W2045247659 @default.
- W2107368518 cites W2049869441 @default.
- W2107368518 cites W2055424082 @default.
- W2107368518 cites W2055919889 @default.
- W2107368518 cites W2056169222 @default.
- W2107368518 cites W2066092773 @default.
- W2107368518 cites W2074201449 @default.
- W2107368518 cites W2077408893 @default.
- W2107368518 cites W2079601009 @default.
- W2107368518 cites W2086725260 @default.
- W2107368518 cites W2091760375 @default.
- W2107368518 cites W2104025073 @default.
- W2107368518 cites W2106505164 @default.
- W2107368518 cites W2107688352 @default.
- W2107368518 cites W2108244474 @default.
- W2107368518 cites W2111428392 @default.
- W2107368518 cites W2112985008 @default.
- W2107368518 cites W2123938765 @default.
- W2107368518 cites W2124479860 @default.
- W2107368518 cites W2125398472 @default.
- W2107368518 cites W2126393744 @default.
- W2107368518 cites W2130035414 @default.
- W2107368518 cites W2146927398 @default.
- W2107368518 cites W2149078679 @default.
- W2107368518 cites W2155321073 @default.
- W2107368518 cites W2172375701 @default.
- W2107368518 cites W2272816834 @default.
- W2107368518 cites W3143360378 @default.
- W2107368518 cites W4237115562 @default.
- W2107368518 cites W4238532154 @default.
- W2107368518 doi "https://doi.org/10.1002/mrd.20473" @default.
- W2107368518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16807888" @default.
- W2107368518 hasPublicationYear "2006" @default.
- W2107368518 type Work @default.
- W2107368518 sameAs 2107368518 @default.
- W2107368518 citedByCount "10" @default.
- W2107368518 countsByYear W21073685182012 @default.
- W2107368518 countsByYear W21073685182016 @default.
- W2107368518 countsByYear W21073685182019 @default.
- W2107368518 countsByYear W21073685182020 @default.
- W2107368518 crossrefType "journal-article" @default.
- W2107368518 hasAuthorship W2107368518A5000769262 @default.
- W2107368518 hasAuthorship W2107368518A5018078683 @default.
- W2107368518 hasAuthorship W2107368518A5076564378 @default.
- W2107368518 hasBestOaLocation W21073685181 @default.
- W2107368518 hasConcept C102230213 @default.
- W2107368518 hasConcept C104317684 @default.
- W2107368518 hasConcept C126322002 @default.
- W2107368518 hasConcept C134018914 @default.
- W2107368518 hasConcept C145103041 @default.
- W2107368518 hasConcept C16685009 @default.
- W2107368518 hasConcept C196843134 @default.
- W2107368518 hasConcept C201750760 @default.
- W2107368518 hasConcept C2776878037 @default.
- W2107368518 hasConcept C28328180 @default.
- W2107368518 hasConcept C28748434 @default.
- W2107368518 hasConcept C54355233 @default.
- W2107368518 hasConcept C60781801 @default.
- W2107368518 hasConcept C62425271 @default.
- W2107368518 hasConcept C71924100 @default.
- W2107368518 hasConcept C86803240 @default.
- W2107368518 hasConcept C87073359 @default.
- W2107368518 hasConcept C95444343 @default.
- W2107368518 hasConceptScore W2107368518C102230213 @default.
- W2107368518 hasConceptScore W2107368518C104317684 @default.
- W2107368518 hasConceptScore W2107368518C126322002 @default.
- W2107368518 hasConceptScore W2107368518C134018914 @default.
- W2107368518 hasConceptScore W2107368518C145103041 @default.
- W2107368518 hasConceptScore W2107368518C16685009 @default.
- W2107368518 hasConceptScore W2107368518C196843134 @default.