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• W2107370312 abstract "Orexin (hypocretin) appears to play a role in the regulation of energy balances. Previous reports have indicated that orexin-containing neurons are found only in the lateral hypothalamic (LH) area. We show that a subset of neurons in the gut which also express leptin receptors display orexin-like immunoreactivity and express functional orexin receptors. Orexin excites secretomotor neurons in the guinea pig submucosal plexus and increases motility. Moreover, fasting upregulates the phosphorylated form of cAMP response element–binding protein (pCREB) in orexin-immunoreactive neurons, indicating a functional response to food status in these cells. Together, these data suggest that orexin in the gut may play an even more intimate role in regulating energy homeostasis than it does in the CNS." @default.
• W2107370312 created "2016-06-24" @default.
• W2107370312 creator A5062199231 @default.
• W2107370312 creator A5075139070 @default.
• W2107370312 date "1999-12-01" @default.
• W2107370312 modified "2023-09-26" @default.
• W2107370312 title "Orexin Synthesis and Response in the Gut" @default.
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• W2107370312 doi "https://doi.org/10.1016/s0896-6273(00)81041-7" @default.
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