FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107387908> ?p ?o ?g. }

• W2107387908 endingPage "264" @default.
• W2107387908 startingPage "260" @default.
• W2107387908 abstract "Abstract: Topical photodynamic therapy (PDT) with methyl-aminolevulinate (MAL) is a well-established treatment for precancerous skin lesions and non-melanoma skin cancer. Treatment outcomes are less effective for thick than for superficial lesions, which are presumed to be due to insufficient PpIX biodistribution in tumour tissue. Hexyl-aminolevulinate (HAL) is a more lipophilic photosensitizer precursor than MAL and may penetrate the skin to a greater depth and more homogeneously. We compared HAL- and MAL-induced PpIX accumulation in specific skin compartments using concentrations of 2%, 6% and 20% HAL and MAL on long-term UV-irradiated mouse skin. Furthermore, 20% HAL and 20% MAL were applied to non-irradiated skin. Porphyrin fluorescence was measured by fluorescence microscopy in selected skin regions: the epidermis, superficial dermis, deep dermis and sebaceous gland epithelium down to a depth of 1 mm. We found higher PpIX fluorescence intensities in epidermis and sebaceous gland epithelium from 2%, 6% and 20% HAL (median 72–104 au) than in corresponding concentrations of MAL (median 35–69 au) (P < 0.01). Fluorescence intensities in the superficial (35 au) and deep dermis (32 au) were similar for HAL and MAL (P = 0.51) and lower than epidermal fluorescence intensities (P < 0.001). Significantly, higher median PpIX fluorescence intensities (64 au) were found in 20% MAL-incubated skin irradiated with UV than in non-irradiated skin (48 au) (P < 0.001). HAL-induced fluorescence intensities did not depend on UV exposure (HAL 20%, UV: 72 au, non-UV: 70 au) (P = 0.87). In conclusion, HAL express high affinity for epidermis and sebaceous gland epithelium, and MAL for actinically damaged skin, which raises future perspectives for improved selectivity in PDT." @default.
• W2107387908 created "2016-06-24" @default.
• W2107387908 creator A5037033048 @default.
• W2107387908 creator A5040426463 @default.
• W2107387908 creator A5050661504 @default.
• W2107387908 creator A5066232478 @default.
• W2107387908 creator A5086669701 @default.
• W2107387908 creator A5091066821 @default.
• W2107387908 date "2012-02-10" @default.
• W2107387908 modified "2023-09-26" @default.
• W2107387908 title "Porphyrin biodistribution in UV-exposed murine skin after methyl- and hexyl-aminolevulinate incubation" @default.
• W2107387908 cites W1542845690 @default.
• W2107387908 cites W1606341412 @default.
• W2107387908 cites W1882738119 @default.
• W2107387908 cites W1963875977 @default.
• W2107387908 cites W1966580456 @default.
• W2107387908 cites W1976372018 @default.
• W2107387908 cites W1978805787 @default.
• W2107387908 cites W1996290414 @default.
• W2107387908 cites W2007460956 @default.
• W2107387908 cites W2020512082 @default.
• W2107387908 cites W2025011011 @default.
• W2107387908 cites W2035646278 @default.
• W2107387908 cites W2035691044 @default.
• W2107387908 cites W2046218295 @default.
• W2107387908 cites W2052703448 @default.
• W2107387908 cites W2052821687 @default.
• W2107387908 cites W2056088027 @default.
• W2107387908 cites W2078316850 @default.
• W2107387908 cites W2081976626 @default.
• W2107387908 cites W2082097084 @default.
• W2107387908 cites W2089275042 @default.
• W2107387908 cites W2094352006 @default.
• W2107387908 cites W2138748891 @default.
• W2107387908 cites W2141594040 @default.
• W2107387908 cites W2153216907 @default.
• W2107387908 cites W2156132669 @default.
• W2107387908 doi "https://doi.org/10.1111/j.1600-0625.2012.01442.x" @default.
• W2107387908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22320713" @default.
• W2107387908 hasPublicationYear "2012" @default.
• W2107387908 type Work @default.
• W2107387908 sameAs 2107387908 @default.
• W2107387908 citedByCount "14" @default.
• W2107387908 countsByYear W21073879082012 @default.
• W2107387908 countsByYear W21073879082013 @default.
• W2107387908 countsByYear W21073879082014 @default.
• W2107387908 countsByYear W21073879082015 @default.
• W2107387908 countsByYear W21073879082016 @default.
• W2107387908 countsByYear W21073879082020 @default.
• W2107387908 countsByYear W21073879082021 @default.
• W2107387908 countsByYear W21073879082022 @default.
• W2107387908 crossrefType "journal-article" @default.
• W2107387908 hasAuthorship W2107387908A5037033048 @default.
• W2107387908 hasAuthorship W2107387908A5040426463 @default.
• W2107387908 hasAuthorship W2107387908A5050661504 @default.
• W2107387908 hasAuthorship W2107387908A5066232478 @default.
• W2107387908 hasAuthorship W2107387908A5086669701 @default.
• W2107387908 hasAuthorship W2107387908A5091066821 @default.
• W2107387908 hasConcept C105702510 @default.
• W2107387908 hasConcept C111337013 @default.
• W2107387908 hasConcept C121332964 @default.
• W2107387908 hasConcept C121608353 @default.
• W2107387908 hasConcept C126322002 @default.
• W2107387908 hasConcept C142724271 @default.
• W2107387908 hasConcept C169274487 @default.
• W2107387908 hasConcept C178790620 @default.
• W2107387908 hasConcept C185544564 @default.
• W2107387908 hasConcept C185592680 @default.
• W2107387908 hasConcept C202751555 @default.
• W2107387908 hasConcept C2776458125 @default.
• W2107387908 hasConcept C2777459323 @default.
• W2107387908 hasConcept C2777624698 @default.
• W2107387908 hasConcept C2777789703 @default.
• W2107387908 hasConcept C2777807558 @default.
• W2107387908 hasConcept C2779480358 @default.
• W2107387908 hasConcept C2781323092 @default.
• W2107387908 hasConcept C2781469039 @default.
• W2107387908 hasConcept C529295009 @default.
• W2107387908 hasConcept C54355233 @default.
• W2107387908 hasConcept C55493867 @default.
• W2107387908 hasConcept C62520636 @default.
• W2107387908 hasConcept C71924100 @default.
• W2107387908 hasConcept C75473681 @default.
• W2107387908 hasConcept C86803240 @default.
• W2107387908 hasConcept C91881484 @default.
• W2107387908 hasConceptScore W2107387908C105702510 @default.
• W2107387908 hasConceptScore W2107387908C111337013 @default.
• W2107387908 hasConceptScore W2107387908C121332964 @default.
• W2107387908 hasConceptScore W2107387908C121608353 @default.
• W2107387908 hasConceptScore W2107387908C126322002 @default.
• W2107387908 hasConceptScore W2107387908C142724271 @default.
• W2107387908 hasConceptScore W2107387908C169274487 @default.
• W2107387908 hasConceptScore W2107387908C178790620 @default.
• W2107387908 hasConceptScore W2107387908C185544564 @default.
• W2107387908 hasConceptScore W2107387908C185592680 @default.
• W2107387908 hasConceptScore W2107387908C202751555 @default.
• W2107387908 hasConceptScore W2107387908C2776458125 @default.
• W2107387908 hasConceptScore W2107387908C2777459323 @default.

• next