Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107404303> ?p ?o ?g. }
- W2107404303 endingPage "212" @default.
- W2107404303 startingPage "208" @default.
- W2107404303 abstract "Photoreceptor cells receive light and transduce it to electrical signals for visual perception. However, excessive exposure to visible light causes photoreceptor cells to undergo apoptosis, which is called photo-damage. This damage involves several biochemical events, including the accumulation of oxidative stress and the elevation of intracellular calcium and nitric oxide (NO). Photo-damage is thought to be related to the progression of retinitis pigmentosa and age-related macular degeneration. Therefore, understanding the molecular mechanisms of retinal photo-damage using model animals may lead to new therapeutic approaches for preventing the progression of these ocular diseases. In this review, we summarize previous reports examining the mechanisms of light-induced retinal damage, and briefly describe the interventional effect of lutein against photo-damage in mice. Lutein is taken from food and systemically delivered to the retina, skin, and certain organs and tissues. It reduces the level of reactive oxygen species and acts as an anti-oxidant in the retina of light-exposed mice, ultimately preventing light-induced DNA double-strand breaks and apoptosis. Although further study is required, lutein may be proposed as a new therapeutic approach for preventing photo-damage in humans." @default.
- W2107404303 created "2016-06-24" @default.
- W2107404303 creator A5000405522 @default.
- W2107404303 creator A5035038653 @default.
- W2107404303 creator A5061193116 @default.
- W2107404303 creator A5061968063 @default.
- W2107404303 creator A5078664015 @default.
- W2107404303 date "2012-01-01" @default.
- W2107404303 modified "2023-10-11" @default.
- W2107404303 title "Photo-damage mechanisms and anti-apoptotic effect of lutein in the mouse retina" @default.
- W2107404303 cites W1480249646 @default.
- W2107404303 cites W1506219883 @default.
- W2107404303 cites W1537261552 @default.
- W2107404303 cites W1678986767 @default.
- W2107404303 cites W1906993142 @default.
- W2107404303 cites W1970068068 @default.
- W2107404303 cites W1977644558 @default.
- W2107404303 cites W1994148925 @default.
- W2107404303 cites W1996243898 @default.
- W2107404303 cites W2007396482 @default.
- W2107404303 cites W2007448480 @default.
- W2107404303 cites W2010324176 @default.
- W2107404303 cites W2010697978 @default.
- W2107404303 cites W2011767660 @default.
- W2107404303 cites W2018698868 @default.
- W2107404303 cites W2020600203 @default.
- W2107404303 cites W2024486785 @default.
- W2107404303 cites W2032754482 @default.
- W2107404303 cites W2036903951 @default.
- W2107404303 cites W2038635135 @default.
- W2107404303 cites W2048058414 @default.
- W2107404303 cites W2052900838 @default.
- W2107404303 cites W2061474331 @default.
- W2107404303 cites W2061690334 @default.
- W2107404303 cites W2063658617 @default.
- W2107404303 cites W2064261105 @default.
- W2107404303 cites W2069166464 @default.
- W2107404303 cites W2079178498 @default.
- W2107404303 cites W2080668613 @default.
- W2107404303 cites W2095778218 @default.
- W2107404303 cites W2097294766 @default.
- W2107404303 cites W2111274886 @default.
- W2107404303 cites W2114145930 @default.
- W2107404303 cites W2120703680 @default.
- W2107404303 cites W2134882067 @default.
- W2107404303 cites W2141087826 @default.
- W2107404303 cites W86894613 @default.
- W2107404303 cites W2289869176 @default.
- W2107404303 doi "https://doi.org/10.2492/inflammregen.32.208" @default.
- W2107404303 hasPublicationYear "2012" @default.
- W2107404303 type Work @default.
- W2107404303 sameAs 2107404303 @default.
- W2107404303 citedByCount "1" @default.
- W2107404303 countsByYear W21074043032015 @default.
- W2107404303 crossrefType "journal-article" @default.
- W2107404303 hasAuthorship W2107404303A5000405522 @default.
- W2107404303 hasAuthorship W2107404303A5035038653 @default.
- W2107404303 hasAuthorship W2107404303A5061193116 @default.
- W2107404303 hasAuthorship W2107404303A5061968063 @default.
- W2107404303 hasAuthorship W2107404303A5078664015 @default.
- W2107404303 hasBestOaLocation W21074043031 @default.
- W2107404303 hasConcept C118487528 @default.
- W2107404303 hasConcept C143425029 @default.
- W2107404303 hasConcept C169760540 @default.
- W2107404303 hasConcept C190283241 @default.
- W2107404303 hasConcept C2776151105 @default.
- W2107404303 hasConcept C2776403814 @default.
- W2107404303 hasConcept C2777093970 @default.
- W2107404303 hasConcept C2778411929 @default.
- W2107404303 hasConcept C2780827179 @default.
- W2107404303 hasConcept C2781040256 @default.
- W2107404303 hasConcept C2781114197 @default.
- W2107404303 hasConcept C28781525 @default.
- W2107404303 hasConcept C54355233 @default.
- W2107404303 hasConcept C552990157 @default.
- W2107404303 hasConcept C55493867 @default.
- W2107404303 hasConcept C71924100 @default.
- W2107404303 hasConcept C86803240 @default.
- W2107404303 hasConcept C95444343 @default.
- W2107404303 hasConceptScore W2107404303C118487528 @default.
- W2107404303 hasConceptScore W2107404303C143425029 @default.
- W2107404303 hasConceptScore W2107404303C169760540 @default.
- W2107404303 hasConceptScore W2107404303C190283241 @default.
- W2107404303 hasConceptScore W2107404303C2776151105 @default.
- W2107404303 hasConceptScore W2107404303C2776403814 @default.
- W2107404303 hasConceptScore W2107404303C2777093970 @default.
- W2107404303 hasConceptScore W2107404303C2778411929 @default.
- W2107404303 hasConceptScore W2107404303C2780827179 @default.
- W2107404303 hasConceptScore W2107404303C2781040256 @default.
- W2107404303 hasConceptScore W2107404303C2781114197 @default.
- W2107404303 hasConceptScore W2107404303C28781525 @default.
- W2107404303 hasConceptScore W2107404303C54355233 @default.
- W2107404303 hasConceptScore W2107404303C552990157 @default.
- W2107404303 hasConceptScore W2107404303C55493867 @default.
- W2107404303 hasConceptScore W2107404303C71924100 @default.
- W2107404303 hasConceptScore W2107404303C86803240 @default.
- W2107404303 hasConceptScore W2107404303C95444343 @default.
- W2107404303 hasIssue "5" @default.