FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107404966> ?p ?o ?g. }

• W2107404966 endingPage "827" @default.
• W2107404966 startingPage "815" @default.
• W2107404966 abstract "Summary Spx , a member of the ArsC (arsenate reductase) protein family, is conserved in G ram‐positive bacteria, and interacts with RNA polymerase to activate transcription in response to toxic oxidants. In B acillus anthracis str. S terne, resistance to oxidative stress requires the activity of two paralogues, SpxA1 and SpxA2 . Suppressor mutations were identified in spxA1 mutant cells that conferred resistance to hydrogen peroxide. The mutations generated null alleles of the saiR gene and resulted in elevated spxA2 transcription. The saiR gene resides in the spxA2 operon and encodes a member of the Rrf2 family of transcriptional repressors. Derepression of spxA2 in a saiR mutant required SpxA2 , indicating an autoregulatory mechanism of spxA2 control. Reconstruction of SaiR ‐dependent control of spxA2 was accomplished in B acillus subtilis , where deletion analysis uncovered two cis ‐elements within the spxA2 regulatory region that are required for repression. Mutations to one of the sequences of dyad symmetry substantially reduced SaiR binding and SaiR ‐dependent repression of transcription from the spxA2 promoter in vitro . Previous studies have shown that spxA2 is one of the most highly induced genes in a macrophage infected with B . anthracis . The work reported herein uncovered a key regulator, SaiR , of the Spx system of stress response control." @default.
• W2107404966 created "2016-06-24" @default.
• W2107404966 creator A5002660892 @default.
• W2107404966 creator A5015425372 @default.
• W2107404966 creator A5037549166 @default.
• W2107404966 creator A5042520164 @default.
• W2107404966 creator A5062069964 @default.
• W2107404966 creator A5063423511 @default.
• W2107404966 creator A5072556527 @default.
• W2107404966 date "2014-10-16" @default.
• W2107404966 modified "2023-10-06" @default.
• W2107404966 title "<i>spxA2</i>, encoding a regulator of stress resistance in<i>B</i><i>acillus anthracis</i>, is controlled by SaiR, a new member of the Rrf2 protein family" @default.
• W2107404966 cites W1509038183 @default.
• W2107404966 cites W1529164899 @default.
• W2107404966 cites W1597403111 @default.
• W2107404966 cites W1877548737 @default.
• W2107404966 cites W1963651147 @default.
• W2107404966 cites W1966517868 @default.
• W2107404966 cites W1966717858 @default.
• W2107404966 cites W1968198478 @default.
• W2107404966 cites W1974559971 @default.
• W2107404966 cites W1981140994 @default.
• W2107404966 cites W1983728587 @default.
• W2107404966 cites W1987732777 @default.
• W2107404966 cites W2008531306 @default.
• W2107404966 cites W2039277799 @default.
• W2107404966 cites W2045103325 @default.
• W2107404966 cites W2046318929 @default.
• W2107404966 cites W2050257011 @default.
• W2107404966 cites W2057744640 @default.
• W2107404966 cites W2060388250 @default.
• W2107404966 cites W2060398925 @default.
• W2107404966 cites W2060663826 @default.
• W2107404966 cites W2069320700 @default.
• W2107404966 cites W2074843227 @default.
• W2107404966 cites W2080163848 @default.
• W2107404966 cites W2080172655 @default.
• W2107404966 cites W2087889125 @default.
• W2107404966 cites W2093688551 @default.
• W2107404966 cites W2096351244 @default.
• W2107404966 cites W2098040384 @default.
• W2107404966 cites W2099915279 @default.
• W2107404966 cites W2112309809 @default.
• W2107404966 cites W2113220951 @default.
• W2107404966 cites W2114593829 @default.
• W2107404966 cites W2124765964 @default.
• W2107404966 cites W2125021980 @default.
• W2107404966 cites W2125489894 @default.
• W2107404966 cites W2125824593 @default.
• W2107404966 cites W2127289590 @default.
• W2107404966 cites W2132684936 @default.
• W2107404966 cites W2148222884 @default.
• W2107404966 cites W2155216305 @default.
• W2107404966 cites W2155819206 @default.
• W2107404966 cites W2158447179 @default.
• W2107404966 cites W2168225803 @default.
• W2107404966 doi "https://doi.org/10.1111/mmi.12798" @default.
• W2107404966 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4258114" @default.
• W2107404966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25231235" @default.
• W2107404966 hasPublicationYear "2014" @default.
• W2107404966 type Work @default.
• W2107404966 sameAs 2107404966 @default.
• W2107404966 citedByCount "12" @default.
• W2107404966 countsByYear W21074049662015 @default.
• W2107404966 countsByYear W21074049662016 @default.
• W2107404966 countsByYear W21074049662017 @default.
• W2107404966 countsByYear W21074049662018 @default.
• W2107404966 countsByYear W21074049662019 @default.
• W2107404966 countsByYear W21074049662020 @default.
• W2107404966 countsByYear W21074049662021 @default.
• W2107404966 countsByYear W21074049662022 @default.
• W2107404966 crossrefType "journal-article" @default.
• W2107404966 hasAuthorship W2107404966A5002660892 @default.
• W2107404966 hasAuthorship W2107404966A5015425372 @default.
• W2107404966 hasAuthorship W2107404966A5037549166 @default.
• W2107404966 hasAuthorship W2107404966A5042520164 @default.
• W2107404966 hasAuthorship W2107404966A5062069964 @default.
• W2107404966 hasAuthorship W2107404966A5063423511 @default.
• W2107404966 hasAuthorship W2107404966A5072556527 @default.
• W2107404966 hasBestOaLocation W21074049661 @default.
• W2107404966 hasConcept C104317684 @default.
• W2107404966 hasConcept C138885662 @default.
• W2107404966 hasConcept C143065580 @default.
• W2107404966 hasConcept C150194340 @default.
• W2107404966 hasConcept C153911025 @default.
• W2107404966 hasConcept C158448853 @default.
• W2107404966 hasConcept C179926584 @default.
• W2107404966 hasConcept C186310378 @default.
• W2107404966 hasConcept C203075996 @default.
• W2107404966 hasConcept C41895202 @default.
• W2107404966 hasConcept C54355233 @default.
• W2107404966 hasConcept C73766848 @default.
• W2107404966 hasConcept C86339819 @default.
• W2107404966 hasConcept C86803240 @default.
• W2107404966 hasConceptScore W2107404966C104317684 @default.
• W2107404966 hasConceptScore W2107404966C138885662 @default.
• W2107404966 hasConceptScore W2107404966C143065580 @default.
• W2107404966 hasConceptScore W2107404966C150194340 @default.

• next