FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107405536> ?p ?o ?g. }

• W2107405536 endingPage "550" @default.
• W2107405536 startingPage "545" @default.
• W2107405536 abstract "Background: We recently developed a novel system for detecting microsatellite alteration, which is an important process in carcinogenesis. In patients with non-small cell lung cancer (NSCLC), loss of heterozygosity (LOH) is frequently observed and causes functional disorders of tumor suppressor genes. Patients and methods: In a consecutive series of 51 patients with NSCLC who had undergone a surgical resection, microsatellite instability (MSI) and LOH in tumors were analyzed by polymerase chain reaction using five fluorescence-labeled dinucleotide markers (D2S123, D5S107, D10S197, D11SS904, and D13S175) and an autosequencer. Results: MSI was detected in only one patient (2.0%) with only one marker. LOH was detected in at least one chromosomal region that was tested in 39 patients (76%). The mean (± SD) number of LOHs detected by each marker was 1.74 ± 1.40, with 1 LOH detected in 10 patients, 2 LOHs detected in 15 patients, 10 LOHs detected in 3 patients, 1 LOH detected in 4 patients, and 3 LOHs detected in 5 patients. The number of LOHs detected in each patient was significantly associated with the pack-year index (ρ = 0.501; p = 0.0004), although there was no relationship with having a history of multiple cancers and familial cancer. Patients with stage IA disease showed a significantly lower number of LOHs than did patients with other stages of disease (1.15 vs 2.38, respectively; p = 0.0013). Conclusion: LOH is very common in patients with NSCLC, and the number of LOHs increases with increases in smoking, suggesting the presence of an important event in lung carcinogenesis. We recently developed a novel system for detecting microsatellite alteration, which is an important process in carcinogenesis. In patients with non-small cell lung cancer (NSCLC), loss of heterozygosity (LOH) is frequently observed and causes functional disorders of tumor suppressor genes. In a consecutive series of 51 patients with NSCLC who had undergone a surgical resection, microsatellite instability (MSI) and LOH in tumors were analyzed by polymerase chain reaction using five fluorescence-labeled dinucleotide markers (D2S123, D5S107, D10S197, D11SS904, and D13S175) and an autosequencer. MSI was detected in only one patient (2.0%) with only one marker. LOH was detected in at least one chromosomal region that was tested in 39 patients (76%). The mean (± SD) number of LOHs detected by each marker was 1.74 ± 1.40, with 1 LOH detected in 10 patients, 2 LOHs detected in 15 patients, 10 LOHs detected in 3 patients, 1 LOH detected in 4 patients, and 3 LOHs detected in 5 patients. The number of LOHs detected in each patient was significantly associated with the pack-year index (ρ = 0.501; p = 0.0004), although there was no relationship with having a history of multiple cancers and familial cancer. Patients with stage IA disease showed a significantly lower number of LOHs than did patients with other stages of disease (1.15 vs 2.38, respectively; p = 0.0013). LOH is very common in patients with NSCLC, and the number of LOHs increases with increases in smoking, suggesting the presence of an important event in lung carcinogenesis." @default.
• W2107405536 created "2016-06-24" @default.
• W2107405536 creator A5004420462 @default.
• W2107405536 creator A5008259417 @default.
• W2107405536 creator A5030864419 @default.
• W2107405536 creator A5053814831 @default.
• W2107405536 creator A5057146510 @default.
• W2107405536 creator A5072940795 @default.
• W2107405536 creator A5089441544 @default.
• W2107405536 date "2003-02-01" @default.
• W2107405536 modified "2023-09-27" @default.
• W2107405536 title "Detection of Loss of Heterozygosity by High-Resolution Fluorescent System in Non-small Cell Lung Cancer*" @default.
• W2107405536 cites W1976056213 @default.
• W2107405536 cites W1993312546 @default.
• W2107405536 cites W1994043644 @default.
• W2107405536 cites W1996225161 @default.
• W2107405536 cites W1997073961 @default.
• W2107405536 cites W2055825222 @default.
• W2107405536 cites W2061445402 @default.
• W2107405536 cites W2072936721 @default.
• W2107405536 cites W2078819900 @default.
• W2107405536 cites W2119363473 @default.
• W2107405536 cites W2132696570 @default.
• W2107405536 cites W2312732552 @default.
• W2107405536 doi "https://doi.org/10.1378/chest.123.2.545" @default.
• W2107405536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12576379" @default.
• W2107405536 hasPublicationYear "2003" @default.
• W2107405536 type Work @default.
• W2107405536 sameAs 2107405536 @default.
• W2107405536 citedByCount "17" @default.
• W2107405536 countsByYear W21074055362012 @default.
• W2107405536 countsByYear W21074055362013 @default.
• W2107405536 countsByYear W21074055362015 @default.
• W2107405536 crossrefType "journal-article" @default.
• W2107405536 hasAuthorship W2107405536A5004420462 @default.
• W2107405536 hasAuthorship W2107405536A5008259417 @default.
• W2107405536 hasAuthorship W2107405536A5030864419 @default.
• W2107405536 hasAuthorship W2107405536A5053814831 @default.
• W2107405536 hasAuthorship W2107405536A5057146510 @default.
• W2107405536 hasAuthorship W2107405536A5072940795 @default.
• W2107405536 hasAuthorship W2107405536A5089441544 @default.
• W2107405536 hasConcept C104317684 @default.
• W2107405536 hasConcept C121608353 @default.
• W2107405536 hasConcept C126322002 @default.
• W2107405536 hasConcept C142724271 @default.
• W2107405536 hasConcept C143589142 @default.
• W2107405536 hasConcept C180754005 @default.
• W2107405536 hasConcept C2776256026 @default.
• W2107405536 hasConcept C49105822 @default.
• W2107405536 hasConcept C54355233 @default.
• W2107405536 hasConcept C555283112 @default.
• W2107405536 hasConcept C71924100 @default.
• W2107405536 hasConcept C86803240 @default.
• W2107405536 hasConceptScore W2107405536C104317684 @default.
• W2107405536 hasConceptScore W2107405536C121608353 @default.
• W2107405536 hasConceptScore W2107405536C126322002 @default.
• W2107405536 hasConceptScore W2107405536C142724271 @default.
• W2107405536 hasConceptScore W2107405536C143589142 @default.
• W2107405536 hasConceptScore W2107405536C180754005 @default.
• W2107405536 hasConceptScore W2107405536C2776256026 @default.
• W2107405536 hasConceptScore W2107405536C49105822 @default.
• W2107405536 hasConceptScore W2107405536C54355233 @default.
• W2107405536 hasConceptScore W2107405536C555283112 @default.
• W2107405536 hasConceptScore W2107405536C71924100 @default.
• W2107405536 hasConceptScore W2107405536C86803240 @default.
• W2107405536 hasIssue "2" @default.
• W2107405536 hasLocation W21074055361 @default.
• W2107405536 hasLocation W21074055362 @default.
• W2107405536 hasOpenAccess W2107405536 @default.
• W2107405536 hasPrimaryLocation W21074055361 @default.
• W2107405536 hasRelatedWork W2016844064 @default.
• W2107405536 hasRelatedWork W2023123213 @default.
• W2107405536 hasRelatedWork W2029465444 @default.
• W2107405536 hasRelatedWork W2035561097 @default.
• W2107405536 hasRelatedWork W2051730198 @default.
• W2107405536 hasRelatedWork W2386203822 @default.
• W2107405536 hasRelatedWork W2405986531 @default.
• W2107405536 hasRelatedWork W2412977291 @default.
• W2107405536 hasRelatedWork W2911684608 @default.
• W2107405536 hasRelatedWork W2914364038 @default.
• W2107405536 hasVolume "123" @default.
• W2107405536 isParatext "false" @default.
• W2107405536 isRetracted "false" @default.
• W2107405536 magId "2107405536" @default.
• W2107405536 workType "article" @default.