Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107409823> ?p ?o ?g. }
- W2107409823 endingPage "28" @default.
- W2107409823 startingPage "205" @default.
- W2107409823 abstract "Chronic obstructive pulmonary disease (COPD) is a global health problem. Being a progressive disease characterized by inflammation and predominantly caused by tobacco smoking, it deteriorates pulmonary and skeletal muscle functioning, and reduces physical behavior, societal participation and quality of life. During the last two decades studies were focused on the airway and systemic inflammation, oxidative stress, and airway and/or parenchymal remodeling. Macrophages, neutrophils and T cells are thought to be important key players, as well as structural cells like fibroblasts, epithelial, endothelial and smooth muscle cells. Mediators and proteins including cytokines, chemokines, growth factors, proteinases, and oxidants seem to be involved differentially in its pathogenesis. Current pharmacological treatments are directed to reducing airway inflammation, boosting the endogenous levels of anti-oxidants and relieving airway contraction and sputum production. Most agents were primarily used for treating asthma. But in contrast to asthma, these treatments are not very effective in COPD. As a result, novel more specifically acting interventional drugs with less side effects are being developed to treat chronic inflammatory diseases, including COPD. This review highlights studies on novel or potential drug antioxidants such as dietary antioxidants supplementation, N-acetyl-L-cysteine, N-acystelyn, endosteine, antioxidant enzyme mimetics, and anti-inflammatory agents like antagonists of cytokines, such as tumor necrosis factor (TNF)-alpha, CXCL8, and CCL2, and inhibitors of signal transduction proteins including phosphodiesterase 4, MAPK p38, P1-3k, and NFkappaB." @default.
- W2107409823 created "2016-06-24" @default.
- W2107409823 creator A5017777839 @default.
- W2107409823 creator A5053405767 @default.
- W2107409823 creator A5058348723 @default.
- W2107409823 date "2007-01-01" @default.
- W2107409823 modified "2023-09-26" @default.
- W2107409823 title "Future therapeutic treatment of COPD: struggle between oxidants and cytokines." @default.
- W2107409823 cites W119247573 @default.
- W2107409823 cites W130086341 @default.
- W2107409823 cites W1493316830 @default.
- W2107409823 cites W1494726887 @default.
- W2107409823 cites W1502595840 @default.
- W2107409823 cites W1538376958 @default.
- W2107409823 cites W1596920894 @default.
- W2107409823 cites W1601924230 @default.
- W2107409823 cites W1606769480 @default.
- W2107409823 cites W1608298415 @default.
- W2107409823 cites W1867483446 @default.
- W2107409823 cites W1921385625 @default.
- W2107409823 cites W1924451767 @default.
- W2107409823 cites W1926036492 @default.
- W2107409823 cites W1933298778 @default.
- W2107409823 cites W1933984380 @default.
- W2107409823 cites W1965150731 @default.
- W2107409823 cites W1967249754 @default.
- W2107409823 cites W1968939050 @default.
- W2107409823 cites W1968960963 @default.
- W2107409823 cites W1968963416 @default.
- W2107409823 cites W1969250371 @default.
- W2107409823 cites W1970779091 @default.
- W2107409823 cites W1972033007 @default.
- W2107409823 cites W1972495472 @default.
- W2107409823 cites W1976290534 @default.
- W2107409823 cites W1978444750 @default.
- W2107409823 cites W1978668173 @default.
- W2107409823 cites W1978761514 @default.
- W2107409823 cites W1979446384 @default.
- W2107409823 cites W1981720291 @default.
- W2107409823 cites W1981893653 @default.
- W2107409823 cites W1984454286 @default.
- W2107409823 cites W1985063313 @default.
- W2107409823 cites W1987413312 @default.
- W2107409823 cites W1991787627 @default.
- W2107409823 cites W1992827508 @default.
- W2107409823 cites W1992978140 @default.
- W2107409823 cites W1993255671 @default.
- W2107409823 cites W1994178441 @default.
- W2107409823 cites W1994375510 @default.
- W2107409823 cites W1994801670 @default.
- W2107409823 cites W1995034916 @default.
- W2107409823 cites W1995472721 @default.
- W2107409823 cites W1996612890 @default.
- W2107409823 cites W1996694581 @default.
- W2107409823 cites W1997101420 @default.
- W2107409823 cites W1997871863 @default.
- W2107409823 cites W1998017399 @default.
- W2107409823 cites W1998305917 @default.
- W2107409823 cites W2000292756 @default.
- W2107409823 cites W2001356286 @default.
- W2107409823 cites W2002584410 @default.
- W2107409823 cites W2003937692 @default.
- W2107409823 cites W2004203825 @default.
- W2107409823 cites W2004556227 @default.
- W2107409823 cites W2004622171 @default.
- W2107409823 cites W2005515353 @default.
- W2107409823 cites W2006779391 @default.
- W2107409823 cites W2006813853 @default.
- W2107409823 cites W2007950026 @default.
- W2107409823 cites W2008962154 @default.
- W2107409823 cites W2013347422 @default.
- W2107409823 cites W2013489935 @default.
- W2107409823 cites W2014025272 @default.
- W2107409823 cites W2015683554 @default.
- W2107409823 cites W2019562019 @default.
- W2107409823 cites W2023662838 @default.
- W2107409823 cites W2024441304 @default.
- W2107409823 cites W2025136858 @default.
- W2107409823 cites W2026058763 @default.
- W2107409823 cites W2027660719 @default.
- W2107409823 cites W2029114978 @default.
- W2107409823 cites W2033193277 @default.
- W2107409823 cites W2034751609 @default.
- W2107409823 cites W2035255427 @default.
- W2107409823 cites W2035567578 @default.
- W2107409823 cites W2035570125 @default.
- W2107409823 cites W2035905848 @default.
- W2107409823 cites W2036368462 @default.
- W2107409823 cites W2037064225 @default.
- W2107409823 cites W2037074841 @default.
- W2107409823 cites W2040099837 @default.
- W2107409823 cites W2041208066 @default.
- W2107409823 cites W2042421205 @default.
- W2107409823 cites W2044803705 @default.
- W2107409823 cites W2045749557 @default.
- W2107409823 cites W2046901940 @default.
- W2107409823 cites W2048103286 @default.
- W2107409823 cites W2048259286 @default.