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- W2107412740 abstract "Some sesquiterpene lactones and related compounds were tested for anti-inflammatory activity in rodents. In the edema-induced carrageenan inflammation screen, the α-methylene-γ-lactone moiety of the sesquiterpene lactones was required for inhibitory activity. The 6-hydroxy group of helenalin also was required for potency. In the tenulin series, the 2,3-epoxy derivatives were marginally active. The same structure was required for inhibition of the writhing reflex. In the chronic adjuvant arthritic screen, compounds containing the cu-methylene-γ lactone moiety, the β-unsubstituted cyclopentenone ring. and the α-epoxy cyclopentenone system afforded significant inhibition at 2.5 mg/kg/day. The sesquiterpene lactones were marginally effective against induced pleurisy. The delayed hypersensitivity was suppressed by these agents whereas immunoglobulin synthesis was slightly stimulated. No deleterious side effects were observed with these agents from the limited testa performed." @default.
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- W2107412740 date "1979-05-01" @default.
- W2107412740 modified "2023-09-26" @default.
- W2107412740 title "Anti-Inflammatory Activity of Sesquiterpene Lactones and Related Compounds" @default.
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- W2107412740 doi "https://doi.org/10.1002/jps.2600680505" @default.
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