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- W2107414458 abstract "Abstract Summary: Efforts to develop peptide-based vaccines, in particular those requiring site-specific targeting of self-proteins, rely on the ability to optimize the immunogenicity of the peptide epitopes. Currently, screening of candidate vaccines is typically performed through low-throughput, high-cost animal trials. To improve on this we present the program EpIC, which enables high-throughput prediction of peptide immunogenicity based on the endogenous occurrence of B-cell epitopes within native protein sequences. This information informs rational selection of immunogenicity-optimized epitopes for peptide vaccines. Availability and implementation: EpIC is available as a web server at http://saphire.usask.ca/saphire/epic. Contact: kdm449@mail.usask.ca" @default.
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- W2107414458 date "2015-03-06" @default.
- W2107414458 modified "2023-10-06" @default.
- W2107414458 title "EpIC: a rational pipeline for epitope immunogenicity characterization" @default.
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- W2107414458 doi "https://doi.org/10.1093/bioinformatics/btv136" @default.
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