Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107434403> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2107434403 endingPage "649" @default.
- W2107434403 startingPage "643" @default.
- W2107434403 abstract "A sensitive method, using gas chromatography with nitrogen selective detection, has been developed for the accurate measurement of methohexitone, in plasma, in concentrations of less than 0.05 mug/ml, and which makes it possible to study the pharmacokinetics of the drug after clinical doses in man. Methohexitone sodium 3.0 mg/kg was administered by zero-order infusion to healthy volunteers and plasma concentrations were measured during and after infusion. The decrease in the plasma concentration of methohexitone can be described by two-compartment kinetics. The terminal elimination half-life of the drug is relatively short (70-125 min), which is a result of a high metabolic clearance rate (657-999 ml plasma/min). It was concluded that uptake of the drug by adipose tissue does not contribute significantly to its pharmacokinetics in man. In addition to the initial redistribution of an anaesthetic dose of methohexitone, the quick recovery of patients is a result of rapid metabolism of the drug." @default.
- W2107434403 created "2016-06-24" @default.
- W2107434403 creator A5077531513 @default.
- W2107434403 date "1976-07-01" @default.
- W2107434403 modified "2023-10-16" @default.
- W2107434403 title "PHARMACOKINETICS OF METHOHEXITONE FOLLOWING INTRAVENOUS INFUSION IN HUMANS" @default.
- W2107434403 cites W137256982 @default.
- W2107434403 cites W1478291124 @default.
- W2107434403 cites W1968152180 @default.
- W2107434403 cites W1978850384 @default.
- W2107434403 cites W1985319965 @default.
- W2107434403 cites W1985401155 @default.
- W2107434403 cites W2000508668 @default.
- W2107434403 cites W2020709519 @default.
- W2107434403 cites W2023282882 @default.
- W2107434403 cites W2033294778 @default.
- W2107434403 cites W2049323720 @default.
- W2107434403 cites W2059438756 @default.
- W2107434403 cites W2073890137 @default.
- W2107434403 cites W2074339926 @default.
- W2107434403 cites W2087143503 @default.
- W2107434403 cites W2120057418 @default.
- W2107434403 cites W2407828891 @default.
- W2107434403 cites W2524296946 @default.
- W2107434403 doi "https://doi.org/10.1093/bja/48.7.643" @default.
- W2107434403 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/797396" @default.
- W2107434403 hasPublicationYear "1976" @default.
- W2107434403 type Work @default.
- W2107434403 sameAs 2107434403 @default.
- W2107434403 citedByCount "101" @default.
- W2107434403 countsByYear W21074344032013 @default.
- W2107434403 countsByYear W21074344032015 @default.
- W2107434403 countsByYear W21074344032017 @default.
- W2107434403 countsByYear W21074344032019 @default.
- W2107434403 crossrefType "journal-article" @default.
- W2107434403 hasAuthorship W2107434403A5077531513 @default.
- W2107434403 hasBestOaLocation W21074344031 @default.
- W2107434403 hasConcept C112705442 @default.
- W2107434403 hasConcept C185592680 @default.
- W2107434403 hasConcept C2780035454 @default.
- W2107434403 hasConcept C3020079912 @default.
- W2107434403 hasConcept C3941253 @default.
- W2107434403 hasConcept C42219234 @default.
- W2107434403 hasConcept C43617362 @default.
- W2107434403 hasConcept C71924100 @default.
- W2107434403 hasConcept C98274493 @default.
- W2107434403 hasConceptScore W2107434403C112705442 @default.
- W2107434403 hasConceptScore W2107434403C185592680 @default.
- W2107434403 hasConceptScore W2107434403C2780035454 @default.
- W2107434403 hasConceptScore W2107434403C3020079912 @default.
- W2107434403 hasConceptScore W2107434403C3941253 @default.
- W2107434403 hasConceptScore W2107434403C42219234 @default.
- W2107434403 hasConceptScore W2107434403C43617362 @default.
- W2107434403 hasConceptScore W2107434403C71924100 @default.
- W2107434403 hasConceptScore W2107434403C98274493 @default.
- W2107434403 hasIssue "7" @default.
- W2107434403 hasLocation W21074344031 @default.
- W2107434403 hasLocation W21074344032 @default.
- W2107434403 hasOpenAccess W2107434403 @default.
- W2107434403 hasPrimaryLocation W21074344031 @default.
- W2107434403 hasRelatedWork W1969876219 @default.
- W2107434403 hasRelatedWork W1978032370 @default.
- W2107434403 hasRelatedWork W1979757582 @default.
- W2107434403 hasRelatedWork W1990964652 @default.
- W2107434403 hasRelatedWork W2049819497 @default.
- W2107434403 hasRelatedWork W2076844872 @default.
- W2107434403 hasRelatedWork W2332367370 @default.
- W2107434403 hasRelatedWork W2400461952 @default.
- W2107434403 hasRelatedWork W4205993769 @default.
- W2107434403 hasRelatedWork W79555446 @default.
- W2107434403 hasVolume "48" @default.
- W2107434403 isParatext "false" @default.
- W2107434403 isRetracted "false" @default.
- W2107434403 magId "2107434403" @default.
- W2107434403 workType "article" @default.