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- W2107452134 abstract "The identification of human mitochondrial DNA (mtDNA) sequence variations, especially single nucleotide polymorphisms (SNPs), is important for many applications. The PCR-ligase detection reaction (LDR) method can reduce false-positives and eliminate the need for both post-PCR and post-ligation purifications in SNP analyses. In addition, it has been successfully employed to detect point mutations in various nuclear genes. In this study, we used the PCR-LDR platform to characterize mtDNA SNPs.Multiplex PCR-LDRs were used to genotype 19 mtDNA single nucleotide polymorphic sites from 812 samples. Performance of the method was assessed by direct sequencing of 44 samples.We established an overall 97.4% success rate with 99.2% accuracy using the multiplex PCR-LDR methodology.The PCR-LDR mtDNA genotyping technique is simple, highly accurate, has high-throughput, and is cost-effective. Therefore, this method is applicable to mtDNA haplotyping in various applications." @default.
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- W2107452134 date "2010-01-01" @default.
- W2107452134 modified "2023-09-27" @default.
- W2107452134 title "Genotyping mitochondrial DNA single nucleotide polymorphisms by PCR ligase detection reactions" @default.
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- W2107452134 doi "https://doi.org/10.1515/cclm.2010.097" @default.
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