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- W2107457435 abstract "ABSTRACT Introduction : In this study we evaluated fracture risk in patients with Charcot–Marie–Tooth (CMT) disease. Methods : We conducted a retrospective cohort study using the UK Clinical Practice Research Datalink (1987–2012). Each patient with CMT disease was matched with up to 6 patients without a history of CMT disease. The outcome measure was fractures. Results : The risk of non‐osteoporotic fracture was statistically significantly increased [adjusted hazard ratio (AHR) 1.47, 95% confidence interval (CI) 1.01–2.14], whereas risk of any and osteoporotic fracture did not reach statistical significance compared with control patients [AHR 1.31 (95% CI 0.98–1.74) and AHR 1.10 (95% CI 0.69–1.74), respectively]. Conclusions : CMT patients have a 1.5‐fold increased risk for non‐osteoporotic fracture. Studies with larger numbers of CMT patients and with additional data on CMT subtype, bone mineral density, and functional status should be performed to confirm a true association between CMT and an increased risk of fracture. Muscle Nerve 50 : 919–924, 2014" @default.
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- W2107457435 date "2014-11-21" @default.
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- W2107457435 title "Risk of fracture in patients with Charcot-Marie-Tooth disease" @default.
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- W2107457435 doi "https://doi.org/10.1002/mus.24240" @default.
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