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- W2107497130 abstract "The preparation of pellets by the extrusion/spheronization process is widely used. Although a body of work already exists which identifies the most important factors involved, there are areas of uncertainty still remaining. One of them is the role of water. In addition to the effect water has on the physical characteristics of the pellets, some authors have also noted that the amount of water required for extrusion can influence the dissolution profiles achieved with this dosage form. The objective of this work was to study the different ways in which water can be considered an active excipient in terms of the amount used to obtain the wet mass, the dispersion within the mass and the drying process. To achieve this goal, a statistical design was performed, considering three levels for the first variable (water content) and two for both the second (pre-extruser storage time) and third (drying process). Physical characteristics of the pellets were analysed for pellets within the same fraction size of 1–1.4 mm diameter. The analysis indicated that the amount of water and the extrusion and drying processes are of great importance and influenced the physical characteristics of the resultant pellets. As the analysis of variance procedure indicates, the influence of the independent variables on the dissolution characteristics of AUC, MDT, RDC and cumulative drug release after 12 h are related in a complex manner to the different pellet performances. Hence, water should be considered as an ‘active’ excipient rather than an inert component of the extrusion masses." @default.
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- W2107497130 date "1996-11-01" @default.
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- W2107497130 title "Influence of process conditions on drug release from pellets" @default.
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- W2107497130 doi "https://doi.org/10.1016/s0378-5173(96)04745-x" @default.
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