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- W2107504080 abstract "Elongation of the Drosophila embryonic hindgut epithelium occurs by a process of oriented cell rearrangement requiring the genes drumstick (drm) and lines (lin). The elongating hindgut becomes subdivided into domains – small intestine, large intestine and rectum – each characterized by a specific pattern of gene expression dependent upon normal drm and lin function. We show that drm encodes an 81 amino acid (10 kDa) zinc finger protein that is a member of the Odd-skipped family. drm expression is localized to the developing midgut-hindgut junction and is required to establish the small intestine, while lin is broadly expressed throughout the gut primordium and represses small intestine fate. lin is epistatic to drm, suggesting a model in which localized expression of drm blocks lin activity, thereby allowing small intestine fate to be established. Further supporting this model, ectopic expression of Drm throughout the hindgut produces a lin phenotype. Biochemical and genetic data indicate that the first conserved zinc finger of Drm is essential for its function. We have thus defined a pathway in which a spatially localized zinc finger protein antagonizes a globally expressed protein, thereby leading to specification of a domain (the small intestine) necessary for oriented cell rearrangement." @default.
- W2107504080 created "2016-06-24" @default.
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- W2107504080 date "2002-08-01" @default.
- W2107504080 modified "2023-09-29" @default.
- W2107504080 title "Drumstick is a zinc finger protein that antagonizes Lines to control patterning and morphogenesis of the<i>Drosophila</i>hindgut" @default.
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- W2107504080 doi "https://doi.org/10.1242/dev.129.15.3645" @default.
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