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- W2107514013 endingPage "770" @default.
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- W2107514013 abstract "Regulatory T cells (T(reg)), also termed suppressor T cells, control self-reactive T cells in the periphery, thereby conferring protection against immunologic self-destruction. While T(reg) are essential for the prevention of autoimmunity, they also inhibit immune responses against tumor antigens. This is corroborated by an increased mortality rate associated with the presence of a high number of intratumoral T(reg). Tumor infiltration by non-T(reg), on the other hand, is predictive for a substantially longer patient survival. These clinical data suggest that ovarian cancer patients can spontaneously mount effective antitumor immune responses that are undermined by T(reg)-mediated tolerization. The present article reviews clinical and experimental findings on T(reg) in ovarian cancer, with special regard to potential therapeutic implications, which may result from the existing evidence." @default.
- W2107514013 created "2016-06-24" @default.
- W2107514013 creator A5055425144 @default.
- W2107514013 creator A5081473975 @default.
- W2107514013 creator A5084072826 @default.
- W2107514013 date "2007-07-01" @default.
- W2107514013 modified "2023-10-14" @default.
- W2107514013 title "The role of regulatory T cells in ovarian cancer" @default.
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- W2107514013 doi "https://doi.org/10.1111/j.1525-1438.2006.00861.x" @default.
- W2107514013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17309663" @default.
- W2107514013 hasPublicationYear "2007" @default.
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