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- W2107517822 abstract "ABSTRACT Bacterial populations produce dormant persister cells that are resistant to killing by all antibiotics currently in use, a phenomenon known as multidrug tolerance (MDT). Persisters are phenotypic variants of the wild type and are largely responsible for MDT of biofilms and stationary populations. We recently showed that a hipBA toxin/antitoxin locus is part of the MDT mechanism in Escherichia coli . In an effort to find additional MDT genes, an E. coli expression library was selected for increased survival to ampicillin. A clone with increased persister production was isolated and was found to overexpress the gene for the conserved aerobic sn -glycerol-3-phosphate dehydrogenase GlpD. The GlpD overexpression strain showed increased tolerance to ampicillin and ofloxacin, while a strain with glpD deleted had a decreased level of persisters in the stationary state. This suggests that GlpD is a component of the MDT mechanism. Further genetic studies of mutants affected in pathways involved in sn -glycerol-3-phosphate metabolism have led to the identification of two additional multidrug tolerance loci, glpABC , the anaerobic sn -glycerol-3-phosphate dehydrogenase, and plsB , an sn -glycerol-3-phosphate acyltransferase." @default.
- W2107517822 created "2016-06-24" @default.
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- W2107517822 date "2006-07-15" @default.
- W2107517822 modified "2023-10-14" @default.
- W2107517822 title "GlpD and PlsB Participate in Persister Cell Formation in <i>Escherichia coli</i>" @default.
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- W2107517822 doi "https://doi.org/10.1128/jb.00369-06" @default.
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