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- W2107529713 abstract "Here, we show that a lupus-suppressing locus is caused by a nonsense mutation of the filamentous actin-inhibiting Coronin-1A gene. This mutation was associated with developmental and functional alterations in T cells including reduced migration, survival, activation, and Ca2+ flux. T-dependent humoral responses were impaired, but no intrinsic B cell defects were detected. By transfer of T cells, it was shown that suppression of autoimmunity could be accounted for by the presence of the Coro1a(Lmb3) mutation in T cells. Our results demonstrate that Coronin-1A is required for the development of systemic lupus and identify actin-cytoskeleton regulatory proteins as potential targets for modulating autoimmune diseases." @default.
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- W2107529713 date "2008-01-01" @default.
- W2107529713 modified "2023-10-02" @default.
- W2107529713 title "The Lupus-Related Lmb3 Locus Contains a Disease-Suppressing Coronin-1A Gene Mutation" @default.
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- W2107529713 doi "https://doi.org/10.1016/j.immuni.2007.11.023" @default.
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