FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W210754388> ?p ?o ?g. }

• W210754388 endingPage "646" @default.
• W210754388 startingPage "639" @default.
• W210754388 abstract "A soluble 67 kDa angiotensin-converting enzyme (ACE) has been purified by lisinopril-Sepharose affinity column chromatography from adult houseflies, Musca domestica. The dipeptidyl carboxypeptidase activity towards benzoyl-Gly-His-Leu was inhibited by captopril (IC50 50 nM) and fosinoprilat (IC50 251 nM), two inhibitors of mammalian ACE, and was activated by Cl- (optimal Cl- concentration 600 mM). Musca ACE removed C-terminal dipeptides from angiotensin I, bradykinin [Leu5]enkephalin and [Met5]enkephalin and also functioned as an endopeptidase by hydrolysing dipeptideamides from [Leu5]enkephalinamide and [Met5]enkephalinamide, and a dipeptideamide and a tripeptideamide from substance P. Musca ACE was also able to cleave a tripeptide from both the N-terminus and C-terminus of luteinizing hormone-releasing hormone, with C-terminal hydrolysis predominating. Maximal N-terminal tripeptidase activity occurred at 150 mM NaCl, whereas the C-terminal tripeptidase activity continued to rise with increasing concentration of Cl- (0-0.5 M). Musca ACE displays properties of both the N- and C-domains of human ACE, indicating a high degree of conservation during evolution of the substrate specificity of ACE and its response to Cl-." @default.
• W210754388 created "2016-06-24" @default.
• W210754388 creator A5013398839 @default.
• W210754388 creator A5020236164 @default.
• W210754388 creator A5036446291 @default.
• W210754388 date "1996-03-01" @default.
• W210754388 modified "2023-09-27" @default.
• W210754388 title "The endopeptidase activity and the activation by Cl− of angiotensin-converting enzyme is evolutionarily conserved: purification and properties of an an angiotensin-converting enzyme from the housefly, <i>Musca domestica</i>" @default.
• W210754388 cites W142262548 @default.
• W210754388 cites W1516407063 @default.
• W210754388 cites W1522513618 @default.
• W210754388 cites W1535139368 @default.
• W210754388 cites W1553543142 @default.
• W210754388 cites W1578637929 @default.
• W210754388 cites W1588015921 @default.
• W210754388 cites W170928467 @default.
• W210754388 cites W1767994247 @default.
• W210754388 cites W1839054962 @default.
• W210754388 cites W1956868294 @default.
• W210754388 cites W1979364657 @default.
• W210754388 cites W1981483940 @default.
• W210754388 cites W1985046771 @default.
• W210754388 cites W1987452330 @default.
• W210754388 cites W1987922381 @default.
• W210754388 cites W2020177273 @default.
• W210754388 cites W2026921577 @default.
• W210754388 cites W2028031469 @default.
• W210754388 cites W2034385018 @default.
• W210754388 cites W2039977410 @default.
• W210754388 cites W2041670760 @default.
• W210754388 cites W2043721542 @default.
• W210754388 cites W2047925788 @default.
• W210754388 cites W2054855670 @default.
• W210754388 cites W2056435519 @default.
• W210754388 cites W2062501223 @default.
• W210754388 cites W2067135939 @default.
• W210754388 cites W2077143473 @default.
• W210754388 cites W2078541862 @default.
• W210754388 cites W2084800579 @default.
• W210754388 cites W2124081426 @default.
• W210754388 cites W2125924413 @default.
• W210754388 cites W2126168922 @default.
• W210754388 cites W2155500010 @default.
• W210754388 cites W2175228938 @default.
• W210754388 cites W2409675826 @default.
• W210754388 doi "https://doi.org/10.1042/bj3140639" @default.
• W210754388 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1217095" @default.
• W210754388 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8670080" @default.
• W210754388 hasPublicationYear "1996" @default.
• W210754388 type Work @default.
• W210754388 sameAs 210754388 @default.
• W210754388 citedByCount "70" @default.
• W210754388 countsByYear W2107543882012 @default.
• W210754388 countsByYear W2107543882013 @default.
• W210754388 countsByYear W2107543882014 @default.
• W210754388 countsByYear W2107543882015 @default.
• W210754388 countsByYear W2107543882016 @default.
• W210754388 countsByYear W2107543882017 @default.
• W210754388 countsByYear W2107543882019 @default.
• W210754388 countsByYear W2107543882020 @default.
• W210754388 countsByYear W2107543882021 @default.
• W210754388 crossrefType "journal-article" @default.
• W210754388 hasAuthorship W210754388A5013398839 @default.
• W210754388 hasAuthorship W210754388A5020236164 @default.
• W210754388 hasAuthorship W210754388A5036446291 @default.
• W210754388 hasBestOaLocation W2107543882 @default.
• W210754388 hasConcept C108477463 @default.
• W210754388 hasConcept C134018914 @default.
• W210754388 hasConcept C167392928 @default.
• W210754388 hasConcept C173758957 @default.
• W210754388 hasConcept C181199279 @default.
• W210754388 hasConcept C182049041 @default.
• W210754388 hasConcept C185592680 @default.
• W210754388 hasConcept C198710026 @default.
• W210754388 hasConcept C2777774944 @default.
• W210754388 hasConcept C2779281246 @default.
• W210754388 hasConcept C2779963888 @default.
• W210754388 hasConcept C54374919 @default.
• W210754388 hasConcept C55493867 @default.
• W210754388 hasConcept C59822182 @default.
• W210754388 hasConcept C84393581 @default.
• W210754388 hasConcept C86803240 @default.
• W210754388 hasConceptScore W210754388C108477463 @default.
• W210754388 hasConceptScore W210754388C134018914 @default.
• W210754388 hasConceptScore W210754388C167392928 @default.
• W210754388 hasConceptScore W210754388C173758957 @default.
• W210754388 hasConceptScore W210754388C181199279 @default.
• W210754388 hasConceptScore W210754388C182049041 @default.
• W210754388 hasConceptScore W210754388C185592680 @default.
• W210754388 hasConceptScore W210754388C198710026 @default.
• W210754388 hasConceptScore W210754388C2777774944 @default.
• W210754388 hasConceptScore W210754388C2779281246 @default.
• W210754388 hasConceptScore W210754388C2779963888 @default.
• W210754388 hasConceptScore W210754388C54374919 @default.
• W210754388 hasConceptScore W210754388C55493867 @default.
• W210754388 hasConceptScore W210754388C59822182 @default.
• W210754388 hasConceptScore W210754388C84393581 @default.
• W210754388 hasConceptScore W210754388C86803240 @default.

• next