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• W2107544447 abstract "Summary Transient increases in the concentration of cytosolic Ca 2+ are essential for triggering egg activation events. Increased Ca 2+ results from its rapid release from intracellular stores, mainly mediated by one or both intracellular calcium channels: the inositol trisphosphate receptor (IP 3 R) and the ryanodine receptor (RyR). Several regulatory pathways that tailor the response of these channels to the specific cell type have been proposed. Among its many modulatory actions, calcium can serve as an activator of a cytosolic phospholipase A 2 (cPLA 2 ), which releases arachidonic acid from phospholipids of the endoplasmic reticulum as well as from the nuclear envelope. Previous studies have suggested that arachidonic acid and/or its metabolites were able to modulate the activity of several ion channels. Based on these findings, we have studied the participation of the phospholipase A 2 (PLA 2 ) pathway in the process of Bufo arenarum oocyte activation and the interrelation between any of its metabolites and the ion channels involved in the calcium release from the intracellular reservoirs at fertilization. We found that addition of both melittin, a potent PLA 2 activator, and arachidonic acid, the main PLA 2 reaction metabolite, was able to induce activation events in a bell-shaped manner. Differential regulation of IP 3 Rs and RyRs by arachidonic acid and its products could explain melittin and arachidonic acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful tools for understanding calcium homeostasis in eggs that express both types of receptors." @default.
• W2107544447 created "2016-06-24" @default.
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• W2107544447 date "2012-02-02" @default.
• W2107544447 modified "2023-10-16" @default.
• W2107544447 title "Role of phospholipase A₂pathway in regulating activation of<i>Bufo arenarum</i>oocytes" @default.
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• W2107544447 doi "https://doi.org/10.1017/s0967199411000645" @default.
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