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- W2107567628 abstract "Burn wound excision and skin grafting is frequently associated with excessive perioperative blood loss necessitating allogeneic blood transfusion. Blood transfusion is associated with both infectious and non-infectious complications and may worsen postoperative outcome. In this report we present our experience with recombinant activated factor VII (rFVIIa) in 17 severely burned patients treated at our institution. In seven patients rFVIIa was administered as a rescue treatment when life-threatening bleeding unresponsive to conventional therapy occurred. Hemostasis was achieved within 15 minutes of rFVIIa administration in all patients. No treatment-related adverse events, in particular thromboembolic events, were observed. Furthermore, as part of a single-center, randomized, double-blind, placebo-controlled, pilot trial involving 18 patients undergoing one-stage major burn surgery, nine patients received prophylactic administration of rFVIIa resulting in a significant 50% reduction in transfusion requirements compared with controls. No treatment-related adverse events were observed. We conclude that rFVIIa may be an effective hemostatic treatment for burn patients undergoing major excision and skin grafting surgery both as rescue therapy and when given as a prophylactic dose prior to surgery." @default.
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- W2107567628 date "2006-12-01" @default.
- W2107567628 modified "2023-10-18" @default.
- W2107567628 title "The use of recombinant activated factor VII in patients undergoing major burn surgery: experiences from a single center" @default.
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- W2107567628 doi "https://doi.org/10.1111/j.1778-428x.2006.00030.x" @default.
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