Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107594181> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2107594181 abstract "Posttraumatic stress sisorder (PTSD) is a complex anxiety disorder that can develop after traumatic event exposure. Genetic factors have been associated with PTSD risk. Recently a variant rs4790904 in the protein kinase C alpha (PRKCA) gene has been shown to be associated with PTSD risk. The objective of this study was to replicate this association in a sample of U.S. Afghanistan/Iraq era veterans.The genotypes of rs4790904 were evaluated in all trauma-exposed veterans. The sample of U.S. veterans included 428 Caucasians and 533 African-Americans. The statistical analysis was conducted independently in the Caucasian and African-American subjects to evaluate the association with PTSD symptom clusters of B symptoms (re-experiencing), C symptoms (avoidance and numbing), D symptoms (hyperarousal), and with current PTSD diagnosis.The sample was comprised of 428 Caucasians (186 with current PTSD diagnosis, 242 trauma-exposed controls; median age, 35 years; 15% female) and 533 African-Americans (205 with current PTSD diagnosis, 328 trauma-exposed controls; median age, 41 years; 31% female). We observed a significant correlation between rs4790904 and all three PTSD symptom clusters in the Caucasian population, but no significant association with current PTSD diagnosis. However, these significant associations were with the G allele, rather than the A allele, that was previously reported by de Quervain. A significant association of this variant with current PTSD diagnosis (p=0.046) was detected in the African-American veterans.We confirmed the correlation between rs4790904 and all three PTSD symptom clusters in the Caucasian but not the African-American population. A significant association with a current diagnosis of PTSD was found in the African-American veterans." @default.
- W2107594181 created "2016-06-24" @default.
- W2107594181 creator A5019050826 @default.
- W2107594181 creator A5061016246 @default.
- W2107594181 creator A5061857570 @default.
- W2107594181 creator A5065246588 @default.
- W2107594181 creator A5066582354 @default.
- W2107594181 creator A5070130436 @default.
- W2107594181 creator A5073138616 @default.
- W2107594181 date "2013-01-01" @default.
- W2107594181 modified "2023-10-17" @default.
- W2107594181 title "Association of Variant rs4790904 in Protein Kinase C Alpha with Posttraumatic Stress Disorder in a U.S. Caucasian and African-American Veteran Sample" @default.
- W2107594181 cites W1987849657 @default.
- W2107594181 cites W1989848972 @default.
- W2107594181 cites W2027845679 @default.
- W2107594181 cites W2035724435 @default.
- W2107594181 cites W2036194871 @default.
- W2107594181 cites W2046147152 @default.
- W2107594181 cites W2048374498 @default.
- W2107594181 cites W2051000959 @default.
- W2107594181 cites W2055545132 @default.
- W2107594181 cites W2068480672 @default.
- W2107594181 cites W2084632987 @default.
- W2107594181 cites W2087119365 @default.
- W2107594181 cites W2129316818 @default.
- W2107594181 cites W2172225647 @default.
- W2107594181 doi "https://doi.org/10.4172/2167-1044.s4-001" @default.
- W2107594181 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4021713" @default.
- W2107594181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24839585" @default.
- W2107594181 hasPublicationYear "2013" @default.
- W2107594181 type Work @default.
- W2107594181 sameAs 2107594181 @default.
- W2107594181 citedByCount "11" @default.
- W2107594181 countsByYear W21075941812014 @default.
- W2107594181 countsByYear W21075941812015 @default.
- W2107594181 countsByYear W21075941812016 @default.
- W2107594181 countsByYear W21075941812017 @default.
- W2107594181 countsByYear W21075941812018 @default.
- W2107594181 countsByYear W21075941812021 @default.
- W2107594181 countsByYear W21075941812022 @default.
- W2107594181 countsByYear W21075941812023 @default.
- W2107594181 crossrefType "journal-article" @default.
- W2107594181 hasAuthorship W2107594181A5019050826 @default.
- W2107594181 hasAuthorship W2107594181A5061016246 @default.
- W2107594181 hasAuthorship W2107594181A5061857570 @default.
- W2107594181 hasAuthorship W2107594181A5065246588 @default.
- W2107594181 hasAuthorship W2107594181A5066582354 @default.
- W2107594181 hasAuthorship W2107594181A5070130436 @default.
- W2107594181 hasAuthorship W2107594181A5073138616 @default.
- W2107594181 hasBestOaLocation W21075941811 @default.
- W2107594181 hasConcept C118552586 @default.
- W2107594181 hasConcept C126322002 @default.
- W2107594181 hasConcept C142853389 @default.
- W2107594181 hasConcept C15744967 @default.
- W2107594181 hasConcept C25110094 @default.
- W2107594181 hasConcept C2778159538 @default.
- W2107594181 hasConcept C2908647359 @default.
- W2107594181 hasConcept C2991847609 @default.
- W2107594181 hasConcept C542102704 @default.
- W2107594181 hasConcept C558461103 @default.
- W2107594181 hasConcept C70410870 @default.
- W2107594181 hasConcept C71924100 @default.
- W2107594181 hasConcept C99454951 @default.
- W2107594181 hasConceptScore W2107594181C118552586 @default.
- W2107594181 hasConceptScore W2107594181C126322002 @default.
- W2107594181 hasConceptScore W2107594181C142853389 @default.
- W2107594181 hasConceptScore W2107594181C15744967 @default.
- W2107594181 hasConceptScore W2107594181C25110094 @default.
- W2107594181 hasConceptScore W2107594181C2778159538 @default.
- W2107594181 hasConceptScore W2107594181C2908647359 @default.
- W2107594181 hasConceptScore W2107594181C2991847609 @default.
- W2107594181 hasConceptScore W2107594181C542102704 @default.
- W2107594181 hasConceptScore W2107594181C558461103 @default.
- W2107594181 hasConceptScore W2107594181C70410870 @default.
- W2107594181 hasConceptScore W2107594181C71924100 @default.
- W2107594181 hasConceptScore W2107594181C99454951 @default.
- W2107594181 hasIssue "01" @default.
- W2107594181 hasLocation W21075941811 @default.
- W2107594181 hasLocation W21075941812 @default.
- W2107594181 hasLocation W21075941813 @default.
- W2107594181 hasLocation W21075941814 @default.
- W2107594181 hasOpenAccess W2107594181 @default.
- W2107594181 hasPrimaryLocation W21075941811 @default.
- W2107594181 hasRelatedWork W1964994059 @default.
- W2107594181 hasRelatedWork W1974712211 @default.
- W2107594181 hasRelatedWork W1981390423 @default.
- W2107594181 hasRelatedWork W2057862516 @default.
- W2107594181 hasRelatedWork W2235450350 @default.
- W2107594181 hasRelatedWork W2754917523 @default.
- W2107594181 hasRelatedWork W3006930704 @default.
- W2107594181 hasRelatedWork W3121122812 @default.
- W2107594181 hasRelatedWork W4313451876 @default.
- W2107594181 hasRelatedWork W4376868132 @default.
- W2107594181 hasVolume "02" @default.
- W2107594181 isParatext "false" @default.
- W2107594181 isRetracted "false" @default.
- W2107594181 magId "2107594181" @default.
- W2107594181 workType "article" @default.