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- W2107621793 abstract "The inhibition by anti-inflammatory drugs of testicular hyaluronidase, and of lysosomal acidic hydrolases present in a rat liver granular fraction, was investigated in vitro. At concentrations needed in plasma for anti-inflammatory effects in man, the clinically useful nonsteroidal anti-inflammatory drugs phenylbutazone, flufenamic and mefenamic acids, indomethacin and ibufenac inhibited hyaluronidase and β-glucuronidase, while aspirin inhibited acid phosphatase and cathepsins. It is suggested these drugs conserve the integrity of cartilage and other connective tissue chondromucoprotein in vivo by inhibiting lysosomal enzymic attack on either the mucopolysaccharide or protein moiety. Permeability factors detected in the granular fraction indicate that, like lysosomal enzymes, they exist latent in vivo within intact sub-cellular particles, and are liberated in an active form only after disruption of the particle membrane. The implications of these factors in inflammation, and their possible relationship to lysosomal enzyme activity and drug action, are discussed." @default.
- W2107621793 created "2016-06-24" @default.
- W2107621793 creator A5032557219 @default.
- W2107621793 date "1968-11-01" @default.
- W2107621793 modified "2023-09-23" @default.
- W2107621793 title "The effect of anti-inflammatory drugs on the enzymic activity of a rat liver granular fraction which increases vascular permeability" @default.
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- W2107621793 doi "https://doi.org/10.1016/0006-2952(68)90032-4" @default.
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