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- W2107632406 abstract "ABSTRACT Viral ribonucleocapsids harboring the viral genomic RNA are used as the template for viral mRNA synthesis and replication of the viral genome by viral RNA-dependent RNA polymerase (RdRp). Here we show that hantavirus nucleocapsid protein (N protein) interacts with RdRp in virus-infected cells. We mapped the RdRp binding domain at the N terminus of N protein. Similarly, the N protein binding pocket is located at the C terminus of RdRp. We demonstrate that an N protein-RdRp interaction is required for RdRp function during the course of virus infection in the host cell." @default.
- W2107632406 created "2016-06-24" @default.
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- W2107632406 date "2014-08-01" @default.
- W2107632406 modified "2023-09-23" @default.
- W2107632406 title "Interaction between Hantavirus Nucleocapsid Protein (N) and RNA-Dependent RNA Polymerase (RdRp) Mutants Reveals the Requirement of an N-RdRp Interaction for Viral RNA Synthesis" @default.
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- W2107632406 doi "https://doi.org/10.1128/jvi.00405-14" @default.
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